3 citations
,
December 2000 in “International Journal of Cosmetic Science” The study created a new method to test drugs that affect hormone processing in skin.
9 citations
,
December 2009 in “Cancer Research” Both vaginal testosterone cream and Estring effectively manage vaginal dryness in women with early-stage breast cancer on aromatase inhibitors.
3 citations
,
January 1985 in “PubMed” Hormonal birth control can cause skin issues, but low-dose options and those with antiandrogens may reduce these effects.
3 citations
,
April 1977 in “PubMed” The treatment improved acne, seborrhoea, and hirsutism, with some side effects like spotting and nervousness.
November 2023 in “International Journal of Women's Dermatology” Hormone replacement therapy may improve hair growth in the frontal hairline of postmenopausal women with hair loss.
1 citations
,
January 2014 in “Side effects of drugs annual” Hormonal contraceptives and related compounds can increase health risks like thrombosis and affect sexual function.
16 citations
,
August 2014 in “International Journal of Women's Health” The estradiol valerate/dienogest oral contraceptive helps with heavy periods, may improve acne and symptoms in PCOS, and doesn't affect sexual function.
20 citations
,
August 2014 in “Therapeutic delivery” The transfollicular route shows promise for noninvasive, targeted drug delivery but needs more research.
June 2026 in “Scientific Reports” This study investigated the effects of systemic testosterone on XX skin, particularly in transgender individuals undergoing gender-affirming hormone treatment. Analyzing discarded skin samples from surgeries, researchers found that testosterone-treated skin showed a 2.77-fold increase in androgen receptor-positive cells, elevated estrogen and progesterone receptor-positive cell counts, a 43% reduction in CD45 positive immune cells, and a 2.93-fold increase in collagen density in the dermis. In the epidermis, there was a reduction in progesterone receptor-positive cells and increased fibronectin expression. These changes suggest that testosterone-treated XX skin develops characteristics similar to male skin, driven by altered sex steroid receptor expression, immune cell infiltration, and structural organization. The study emphasizes the need for further research to understand the mechanisms of testosterone-induced skin remodeling and its impact on surgical outcomes.
10 citations
,
January 2016 in “Dermatology Online Journal” Hormonal therapy in transgender patients can lead to skin changes like altered sebum production, hair growth, and acne, which may require dermatological care.
1 citations
,
June 2022 in “JAAD case reports” A woman developed a severe skin reaction after getting a birth control implant.
88 citations
,
June 2016 in “Human Reproduction Update” New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.
8 citations
,
January 1998 in “Journal of Investigative Dermatology” Topical estrogen treatments did not change hair growth in certain mouse strains, questioning previous findings on their role in hair growth control.
1 citations
,
July 2024 in “Journal of Plastic Reconstructive & Aesthetic Surgery” Estrogen therapy can help stabilize the hairline in transfeminine individuals.
8 citations
,
March 2008 in “Deutsche medizinische Wochenschrift/Deutsche Medizinische Wochenschrift” Adding estrogen increased bone mass in a transsexual man undergoing hormone therapy.
1 citations
,
December 2022 in “Pharmaceutics” Finasteride-loaded microemulsions can effectively enhance skin delivery for treating hair loss.
1 citations
,
November 2007 in “Neuro-chirurgie/Neurochirurgie” Cyproterone acetate is a safe treatment that causes modest feminization in transgender female adolescents, and works better with added estrogens.
Cyproterone acetate with ethynyl estradiol significantly improved acne and seborrhea in women, but was less effective for hair loss and excessive hair growth.
May 2013 in “UTUPub (University of Turku)” Including androgens in hormone therapy may lower breast cancer risk.
4 citations
,
August 2025 in “Journal of Cosmetic Dermatology” Hormone replacement therapy can improve menopausal skin quality, but it's not recommended just for skin due to limited evidence.
33 citations
,
May 1984 in “Journal of Pharmacy and Pharmacology” Liposomes are not better than acetone for applying DHT on skin.
1 citations
,
January 1999 in “The European journal of contraception & reproductive health care” Valette® is an effective birth control pill that also reduces greasy hair and skin.
7 citations
,
April 2009 in “Bioorganic & Medicinal Chemistry Letters” Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
January 2023 in “Journal of cosmetic dermatology” The synthetic retinoid EC23 thickens skin and promotes hair growth more effectively and with a lower dose than natural retinoids.
March 2026 in “Research Square” 4 citations
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July 2023 in “Journal of Cosmetic Dermatology” Adapalene microemulsions improve drug delivery through hair follicles, enhancing acne treatment.
Testosterone pellet therapy may better address hormone imbalances in aging by focusing on local hormone production and symptom relief.
22 citations
,
January 2001 in “Chemical & Pharmaceutical Bulletin” Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.
17 citations
,
January 2004 in “European journal of obstetrics, gynecology, and reproductive biology/European journal of obstetrics & gynecology and reproductive biology” Certain hormone medications can treat symptoms like acne and unwanted hair, regulate periods, and prevent pregnancy in women and teenage girls.
4 citations
,
August 2024 in “PLoS ONE” Both injectable contraceptives lower testosterone and SHBG levels, with NET-EN having a greater effect than DMPA-IM.