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research Chronic Treatment with Minoxidil Induces Elastic Fiber Neosynthesis and Functional Improvement in the Aorta of Aged Mice

23 citations , June 2017 in “Rejuvenation Research”

Minoxidil treatment increases aorta elasticity and reduces stiffness in aged mice, potentially helping with age-related heart issues.

research Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model

June 2025 in “Journal of Photochemistry and Photobiology B Biology”

UVA exposure worsens hair loss by activating a specific cell pathway.

research Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair: Wnt1/βcatenin injury response regulates cardiac repair

1 citations , November 2020

The Wnt1/βcatenin pathway is crucial for heart repair after injury.

research Orai1 expression pattern in tooth and craniofacial ectodermal tissues and potential functions during ameloblast differentiation

15 citations , July 2015 in “Developmental Dynamics”

Orai1 protein is crucial for tooth development and affects enamel thickness and mineralization.

Maternal Androgen Excess Inhibits Fetal Cardiomyocyte Proliferation Through RB-Mediated Cell Cycle Arrest and Induces Cardiac Hypertrophy in Adulthood

research Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood

2 citations , August 2023 in “Journal of Endocrinological Investigation”

Excess maternal androgens can cause heart problems in offspring.

Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells

research Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

August 1994 in “Molecular Endocrinology”

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

research Direct-Acting Vasodilators

40 citations , July 2011 in “The journal of clinical hypertension”

Hydralazine and minoxidil are blood pressure medications that relax blood vessels, with potential side effects like rapid heartbeat and fluid retention, and are used for severe or pregnancy-related hypertension.

research Urinary symptoms in patients with androgenetic alopecia

February 2010 in “Journal of The American Academy of Dermatology”

Lower nitric oxide and higher fibrinogen found in hirsute women; impaired sexual function in 22.6% of hair loss patients, linked to psoriasis severity.

research Outer root sheath cells secrete oxytocin for hair growth promotion and stem cell proliferation

March 2026 in “Journal of Bioscience and Bioengineering”

Oxytocin from hair cells helps hair growth and stem cell increase.

research Unusual Anti-Angiogenic Effect of Combined Hormonal Blockade

1 citations , October 2002 in “The Journal of Urology”

research Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria

29 citations , December 2017 in “Molecular therapy”

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

research Safety and efficacy of advanced and targeted acid α-glucosidase (AT-GAA) (ATB200/AT2221) in ERT-switch nonambulatory patients with Pompe disease: preliminary results from the ATB200-02 trial

3 citations , February 2019 in “Molecular genetics and metabolism”

The combination of tadalafil and finasteride improves urinary symptoms and erectile function in men with enlarged prostates.

research 11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes

43 citations , August 2010 in “Expert Opinion on Investigational Drugs”

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

research Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro

51 citations , February 2009 in “Journal of dermatological science”

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

research LB1007 Systemic treatment with a KLK5 inhibitor shows efficacy in a murine model of Netherton syndrome

July 2024 in “Journal of Investigative Dermatology”

A KLK5 inhibitor effectively improved skin symptoms in a mouse model of Netherton Syndrome.

research The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor

16 citations , August 2021 in “Tumor Biology”

TMPRSS2 helps viruses enter cells and protects the prostate from inflammation-related cancer.

research Most recent findings of curative drugs for lower urinary tract symptoms in clinical practice

January 2019 in “Nihon Yakuri Gakkai nenkai yoshishu”

Current treatments for lower urinary tract symptoms include α1-blockers, 5ARIs, PDE5 inhibitors, anticholinergic agents, and β3-adrenergic receptor agonists.