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GlossarySkin Damage

harm to skin's structure and function from various factors

Skin damage refers to any harm or injury to the skin's structure and function, which can result from various factors such as UV radiation, physical trauma, chemical exposure, or infections. This damage can manifest as sunburn, cuts, abrasions, rashes, or more severe conditions like burns and chronic wounds, potentially leading to complications like scarring, infection, or impaired healing.

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Efficient Intradermal Delivery of Superoxide Dismutase Using a Combination of Liposomes and Iontophoresis for Protection Against UV-Induced Skin Damage

research Efficient Intradermal Delivery of Superoxide Dismutase Using a Combination of Liposomes and Iontophoresis for Protection against UV-Induced Skin Damage

21 citations , January 2012 in “Biological and Pharmaceutical Bulletin”

Liposomes and iontophoresis effectively deliver protective enzymes into the skin against UV damage.

research Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

184 citations , October 2007 in “Proceedings of the National Academy of Sciences of the United States of America”

Sulforaphane from broccoli can help protect skin from sun damage.

research 740 Vitamin D protection against acute UV damage – A critical role of autophagy in the skin

April 2016 in “Journal of Investigative Dermatology”

Vitamin D can reduce skin inflammation caused by UV rays by enhancing cell "fitness" and skin repair.

Transepidermal UV Radiation of Human Scalp Skin Induces Distinctive Hair Follicle Damage, Mitigated by Topical Caffeine Treatment

research 910 Transepidermal UV radiation of human scalp skin induces distinctive hair follicle damage, which is mitigated by topical caffeine treatment

April 2019 in “Journal of Investigative Dermatology”

Caffeine can protect scalp hair follicles from damage caused by UV radiation.

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

76 citations , February 2007 in “Cancer Research”

Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

research 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage

1 citations , April 2016 in “Journal of Investigative Dermatology”

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

research Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator

31 citations , January 2011 in “Dermato-endocrinology”

Melatonin protects skin against UV damage by regulating various cellular processes.

research Author response: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

November 2021

Different types of skin cells and immune cells play a role in healing UV-damaged skin, with chronic UV exposure causing lasting damage to certain skin cells.

research Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

Different types of sun exposure can damage skin cells and affect healing, with chronic exposure being more harmful, and certain immune cells help in the repair process.

research Montagna Symposium 2013—Light and Skin: How Light Sustains, Damages, Treats, Images and Modifies Skin Biology

1 citations , July 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Light affects skin health, aging, and cancer risk, and new light-based treatments and imaging are promising for skin care.

research Advances in Extraction Technologies of Silybum marianum L. and Its Role in Protecting Against Skin Damage

1 citations , September 2025 in “Cosmetics”

Milk thistle can protect skin from damage and aging.

research The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions

January 2026 in “Aging and Disease”

Targeting mitochondria can improve skin health and slow aging.

Transepidermal UV Radiation of Scalp Skin Ex Vivo Induces Hair Follicle Damage That Is Alleviated by Topical Treatment with Caffeine

research Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine

31 citations , February 2019 in “International Journal of Cosmetic Science”

Caffeine applied to the scalp can protect hair follicles from UV damage.

Enhancement of Skin Rejuvenation and Hair Growth Through Novel Near-Infrared LED Lighting: In Vitro and In Vivo Study

research Enhancement of skin rejuvenation and hair growth through novel near-infrared light emitting diode (nNIR) lighting: in vitro and in vivo study

April 2024 in “Lasers in medical science”

Near-infrared LED light improves skin rejuvenation and hair growth better than white LED light.

Effect of Conditioned Media Collected from Human Amniotic Fluid-Derived Stem Cells on Skin Regeneration and Photo-Aging

research Effect of conditioned media collected from human amniotic fluid-derived stem cells (hAFSCs) on skin regeneration and photo-aging

9 citations , February 2014 in “Tissue Engineering and Regenerative Medicine”

Conditioned media from human amniotic fluid-derived stem cells helps skin heal and protects against aging from sun exposure.

research Structure and Function of the Skin

1 citations , January 2012 in “Elsevier eBooks”

The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.

research On the Role of Melatonin in Skin Physiology and Pathology

222 citations , January 2005 in “Endocrine journal”

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

research Protective Effects of Melatonin on the Skin: Future Perspectives

44 citations , October 2019 in “International Journal of Molecular Sciences”

Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.

research Respective Treatment Modalities with the Use of Combined Ingredients to Address Acne Prone Skin

July 2021 in “Journal of dermatology research and therapy”

Using combined treatments can help manage acne by targeting the bacteria and skin changes that cause it.

research The Circadian Clock in Skin

127 citations , January 2015 in “Journal of Biological Rhythms”

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

research Aging Skin: A Window to the Body

1 citations , April 2016 in “CRC Press eBooks”

Skin aging reflects overall body aging and can indicate internal health conditions.

Characterization of Interfollicular Stem Cells and Early TA Cells During the Transition From Infant to Child Skin

research 331 Characterisation of interfollicular stem cells and early TA cells during the transition from infant to child skin

October 2021 in “Journal of Investigative Dermatology”

The study concludes that as skin matures from infancy to childhood, there are major changes in cell differentiation, stemness, and growth, leading to a stronger skin barrier in older children.

research Non-denatured Soybean Extracts in Skin Care: Multiple Anti-Aging Effects

2 citations , April 2011 in “InTech eBooks”

Non-denatured soybean extracts provide multiple anti-aging skin benefits.

research Comparison of DNA repair systems in infant, children, or adult skin cells—Impact of full-solar-spectrum irradiation

August 2018 in “Journal of The American Academy of Dermatology”

Infant skin cells may be less capable of repairing UV-induced DNA damage than adult cells.