August 2026 in “Regenerative Biomaterials” This review discusses the limitations of conventional animal models and two-dimensional cultures in studying cutaneous pigmentary disorders such as vitiligo, melasma, post-inflammatory hyperpigmentation, and solar/senile lentigines. It evaluates advanced in vitro models, including ex vivo explants, co-cultures, three-dimensional skin equivalents, bioprinted constructs, organoids, and skin-on-a-chip platforms. These models are assessed based on their ability to replicate human pigmentation processes, disease-specific pathological processes, and their potential for mechanistic studies and therapeutic evaluation. The review highlights challenges such as vascular and immune integration, long-term stability, and regulatory acceptance, emphasizing the need for improved models within the framework of New Approach Methodologies.
February 2025 in “BMC Veterinary Research” Keratin proteins are crucial for hair growth in cashmere goats.
37 citations
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October 2009 in “Dermatology” Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.
14 citations
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November 2012 in “SLAS discovery” Some herbal extracts can promote hair growth and prevent hair loss.
32 citations
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May 2018 in “Cell Cycle” Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.
16 citations
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December 2012 in “Bioinformation” Curcumin, EGCG, barringtozenol, and finasteride are effective VEGFR inhibitors.
January 2024 in “Bratislavské lekárske listy/Bratislava medical journal” Chloroquine and cinchonine relax rat blood vessels by affecting calcium channels, with chloroquine needing caution in heart patients.
421 citations
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January 2015 in “Chemical Society Reviews” Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.
16 citations
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September 2021 in “Frontiers in Bioengineering and Biotechnology” The nanofibers improved cell adhesion and could be used for tissue-engineered blood vessels.
January 2025 in “Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)” Erectile dysfunction is linked to hormone imbalances and vascular health, requiring personalized treatment approaches.
January 2019 in “ISGE series” Estrogen helps prevent artery plaque by stopping monocyte capture in blood vessels.
June 2026 in “International Journal of Ayurvedic Medicine” Ayurvedic methods align well with trichoscopic imaging for diagnosing and managing hair loss.
21 citations
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December 2023 in “Bioengineering & Translational Medicine” Fibroblast and endothelial cell interactions are crucial in forming hypertrophic scars.
April 2026 in “Scientific Reports” Capillary and dermal papilla interactions are vital for hair growth and aging, with potential for treating hair loss.
September 2025 in “Cuadernos de Educación y Desarrollo” Laser and light technologies are used in dermatology for skin treatments and improving outcomes.
Autologous Regenerative Therapy may improve hair restoration by using stem cells from fat.
December 2015 in “Vascular Pharmacology” Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.
17 citations
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February 2025 in “Smart Medicine” The microneedle patch speeds up wound healing and prevents infection.
GPC1 is important for hair growth by helping blood vessels form around hair follicles.
GPC1 is important for blood vessel growth in hair follicles and could help treat hair loss.
Glypican-1 is important for hair follicle blood vessel growth and could be a target for treating hair loss.
202 citations
,
August 2007 in “Biomaterials” Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.
10 citations
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January 2013 in “Regenerative Medicine Research” Rejuvenating self-repair mechanisms could improve organ recovery in regenerative medicine.
January 2022 in “Stem cell biology and regenerative medicine” The document concludes that hair follicle regeneration involves various factors like stem cells, noncoding dsRNA, lymphatic vessels, growth factors, minoxidil, exosomes, and induced pluripotent stem cells.
May 2026 in “Organoid Research” Hydrogel-based methods improve skin organoid development for medical and research applications.
12 citations
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September 2024 in “JID Innovations” Skin-on-a-chip devices better mimic human skin for research.
June 2026 in “International Journal of Bioprinting” 3D bioprinting shows promise for skin regeneration but needs more development to fully replicate natural skin.
March 2026 in “Chemical Engineering Journal” The hydrogel helps heal diabetic wounds by combining antibacterial, antioxidant, and immune-boosting effects.
December 2025 in “Yassawi Journal of Health Sciences” Trichoscopy is essential for accurately diagnosing and differentiating types of hair loss.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Immune cells are essential for early hair and skin development and healing.