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GlossaryVitamin D Receptor

protein that binds vitamin D to regulate gene expression

The Vitamin D Receptor (VDR) is a protein found in various cells throughout the body that binds to vitamin D, allowing it to regulate the expression of specific genes. This receptor plays a crucial role in maintaining calcium and phosphate balance, which is essential for healthy bone formation, and it also influences immune system function and hair follicle cycling.

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Stress-Induced c-Jun-Dependent Vitamin D Receptor Activation Dissects the Non-Classical VDR Pathway from the Classical VDR Activity

research Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity

31 citations , January 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

research Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms

18 citations , October 2009 in “Endocrinology”

Different Hairless isoforms affect Vitamin D receptor activity in hair regulation, with one repressing and the other stimulating it.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid

research Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

2 citations , November 2017 in “PloS one”

Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

research 975 Antifibrogenic activities of novel vitamin D3 analogs are dependent on VDR expression in human fibroblasts

April 2019 in “Journal of Investigative Dermatology”

New vitamin D3 forms need the vitamin D receptor to reduce fibrosis in human cells.

research Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells

17 citations , April 2007 in “Kidney international”

Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.

research The Molecular Biology of the Vitamin D Receptor

22 citations , January 2010 in “Humana Press eBooks”

The vitamin D receptor can affect gene activity even without its usual hormone in hair and skin.

research Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function

5 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease”

Hairless protein helps control hair growth by regulating vitamin D receptor activity.

research Vitamin D Receptor: New Assignments for an Already Busy Receptor

510 citations , August 2006 in “Endocrinology”

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research Vitamin D receptor is essential for normal keratinocyte stem cell function

143 citations , May 2007 in “Proceedings of the National Academy of Sciences”

Vitamin D receptor is crucial for normal hair growth and preventing hair loss.

Cloning of a Functional Vitamin D Receptor from the Lamprey, an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

104 citations , May 2003 in “Endocrinology”

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

research Hereditary vitamin D-resistant rickets (HVDRR) owing to a heterozygous mutation in the vitamin D receptor

37 citations , August 2011 in “Journal of Bone and Mineral Research”

A girl had rickets due to a gene mutation affecting vitamin D response.

research Evidence for 1,25-Dihydroxyvitamin D3-independent Transactivation by the Vitamin D Receptor

36 citations , February 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

The vitamin D receptor can work without its usual activating molecule.

research Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle

22 citations , April 2010 in “Journal of Cellular Biochemistry”

Certain mutations in the hairless protein disrupt its ability to regulate the hair cycle.

research Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia

20 citations , July 2017 in “Scientific Reports”

A single amino acid change in the vitamin D receptor can disrupt its function and lead to hair loss.

research Novel Vitamin D Receptor Mutations in Hereditary Vitamin D Resistant Rickets in Chinese

10 citations , September 2015 in “PLoS ONE”

New mutations in the VDR gene cause vitamin D-resistant rickets without hair loss.

Phenotypic Heterogeneity in Five Japanese Patients with an Identical Point Mutation in the Vitamin D Receptor Gene

research Phenotypic Heterogeneity in 5 Japanese Patients with an Identical Point Mutation in the Vitamin D Receptor Gene

3 citations , January 1992 in “Clinical Pediatric Endocrinology”

Patients with the same vitamin D receptor mutation showed different symptoms due to other factors.

research Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor^†

10 citations , February 2008 in “Photochemistry and photobiology”

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

research Vitamin D and calcium regulation of epidermal wound healing

86 citations , August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Vitamin D and calcium are essential for effective wound healing and hair growth.

research Topical Calcipotriol versus oral vitamin D in the treatment of alopecia areata

3 citations , March 2019 in “Fayoum University Medical Journal/Fayoum University Medical Journal ”

Rubbing calcipotriol on the skin works better than taking vitamin D pills for treating mild to moderate alopecia areata.

research The role of vitamin D in alopecia areata

1 citations , January 2016 in “Dermatology Review”

Vitamin D might help treat alopecia areata.

research C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata

March 2024 in “Skin research and technology”

High CRP levels could indicate vitamin D deficiency in people with alopecia areata.

research Analyse de la régulation du gène Hairless et identification des voies de signalisation affectées chez les mutants «bald Mill Hill».

January 2008 in “HAL (Le Centre pour la Communication Scientifique Directe)”

The mutant HR bmh protein affects hair follicle formation by failing to repress vitamin D receptor activity.

research Pinkie, the First Viable Germline Hypomorph Allele of Retinoid X Receptor Alpha, Reveals an Important Role for RXRa in Th2 Development.

2 citations , November 2004 in “Blood”

RXRa is crucial for Th2 immune cell development and may link nutrition to immune health.

research A novel missense mutation in the mouse hairless gene causes irreversible hair loss: Genetic and molecular analyses of Hrm1Enu

18 citations , February 2006 in “Genomics”

A new genetic mutation in mice causes permanent hair loss and skin wrinkling.

research Impact of Reducing Obesity in PCOS: Methods and Treatment Outcomes

1 citations , October 2025 in “Journal of Personalized Medicine”

Weight loss improves PCOS symptoms and overall health.