research Transcriptomic profiling in Silurana tropicalis testes exposed to finasteride
Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
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780-810 / 1000+ results research Synthetically programmed antioxidant delivery by a domesticated skin commensal
Engineered bacteria can deliver antioxidants to protect skin.
research TOC
Understanding drug effects and careful monitoring are crucial for safe and effective dermatology treatments.
research Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3
Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.
research Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics
Efficient enzyme function relies on specific residue interactions and structural coordination.
research NEW PROPRIETARY BRANDS: Cefaclor monohydrate
Lifestyle changes are more effective than medication for reducing type 2 diabetes risk.
research Forum
The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.
research UHPLC/Q-TOFMS-based plasma metabolomics of polycystic ovary syndrome patients with and without insulin resistance
The research found different metabolism changes in PCOS patients and suggested new potential markers for diagnosing PCOS with or without insulin resistance.
research Impact of Clinical Response on Different Approved Doses in Japan and the United States
Different drug doses approved in Japan and the U.S. are not mainly due to different clinical responses, and ethnic factors should be considered in setting drug doses.
research Antioxidants and Mitochondrial Bioenergetics
Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.
research Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility
Blocking progesterone metabolism can cause depression-like behavior in mice.
research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate
Scientists made two new chemicals that might help treat diseases caused by male hormones.
research Significant effects of mild endogenous hormonal changes in humans: considerations for low-dose testing.
Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.
research Determination of Residual Organic Solvents in Finasteride Raw Materials by Headspace Capillary Gas Chromatography
The method effectively detects residual solvents in finasteride raw materials.
research Isotretinoin-unresponsive acne as a sign of a congenital disorder: a case of 21-hydroxylase deficiency
Acne not improved by usual treatments may indicate a genetic disorder.
research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport
Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.
research ABSTRACTS—SYMPOSIA
Certain drugs can block changes in brain receptors caused by alcohol withdrawal.
research Lifestyle Drugs in Old Age – A Mini-Review
Older adults use lifestyle drugs to improve life quality and appearance, but caution is needed due to side effects and potential abuse.
research Studies on the pharmacokinetics and bioquivalence of domestic finasteride tablet in healthy volunteers
Domestic and imported finasteride tablets work the same in the body.
research Medicinal Chemistry of Drugs with N-Oxide Functionalities
N-oxides are important in medicine for improving drug properties and targeting.
research CROSS-META-ANALYSIS ON POLICOSANOL BIOREFINING: AN INNOVATIVE TECHNOLOGY PROSPECTING PROTOCOL WITH IBERO-AMERICAN INSIGHTS
Policosanol biorefining shows promise for heart health, needing better academic-industrial collaboration.
research A COMPARISON OF THE TOXICITIES OF 4-(ETHOXYCARBOPHENYL) RETINAMIDE AND SOME OTHER RETINOIDS
4-(Ethoxycarbophenyl) retinamide is much less toxic than other retinoids.
research PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators
PROTACs show promise in cancer treatment by effectively degrading specific harmful proteins.
research The Metabolism of Dehydroepiandrosterone by Human Scalp Hair Follicles
Altered DHEA metabolism in hair follicles may be linked to hair loss in balding men.
research Significant Effects of Mild Endogenous Hormonal Changes in Humans: Considerations for Low-Dose Testing
Small hormonal imbalances can cause significant health problems, so more sensitive testing for hormone-disrupting chemicals is needed.
research BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
A reliable method was developed to measure Finasteride and Tadalafil in rat blood.
research Reporting on Adverse Clinical Events
Some medications and supplements can cause serious side effects, including hair loss, heart rhythm problems, liver injury, and other health issues.
research Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: Potential role of endogenous neurosteroids?
Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.
research Exposure to non-persistent pesticides and sexual maturation of Spanish adolescent males
Certain pesticides may delay sexual maturity in teenage boys.