Black Ginseng Concentrate Restores Hair Loss-Associated Dysfunction in Human Follicle Dermal Papilla Cells

June 2026 in “ International Journal of Molecular Sciences ”

Jung Un Shin, Yun Hoo Jo, Minha Kim, Jungwon Min, Ki Soo Kim, Byeong Bae Jeon, Uk Sun Jung, Ki Hyun Kim, Eui Soon Kim, Chulwan Kim, S E Lee, Dong Wook Shin

Black Ginseng Concentrate human follicle dermal papilla cells oxidative stress mitochondrial function reactive oxygen species cell migration Wnt/β-Catenin signaling pathway ERK/AKT signaling pathway natural therapeutic agent cosmetic material hair growth-related signaling pathways BGC HFDPCs ROS

TLDR Black Ginseng Concentrate may help treat hair loss by improving cell function and reducing stress.

The study demonstrates that Black Ginseng Concentrate (BGC) effectively restores hair loss-associated dysfunction in human follicle dermal papilla cells (HFDPCs) by reducing oxidative stress and enhancing mitochondrial function. BGC decreases intracellular reactive oxygen species (ROS) levels, improves cell migration, and activates key hair growth-related signaling pathways, such as Wnt/β-Catenin and ERK/AKT. The research highlights BGC's potential as a natural therapeutic agent for hair loss, offering a promising alternative to current treatments. The study's findings, based on three independent biological experiments, suggest that BGC could be developed as a cosmetic material targeting oxidative stress-related hair disorders.

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