<i>In vitro</i> and <i>in vivo</i> models for androgenetic alopecia drug development

This article discusses the challenges and advancements in developing drug testing models for androgenetic alopecia (AGA), a common form of hair loss. Traditional models, such as two-dimensional cultures and animal models, have limitations in accurately replicating human hair follicle structures and signaling pathways. The article highlights the potential of three-dimensional culture platforms to address these issues, offering better functional readouts, reproducibility, and high-throughput potential. It also emphasizes the importance of selecting appropriate models for initial drug screening to improve the development of effective hair loss treatments. Overall, the article provides a guide for creating more relevant screening systems for AGA drug development.