Multiomics Analysis Reveals Molecular Pathways Associated With the Effects of <i>Pinus massoniana</i> Needles Extract on Androgenetic Alopecia

January 2026 in “ Dermatologic Therapy ”

Hongliu Zhu, Jie Yang, 毛秋霞, Xuling Wu, Zixi Wang, Lechi Feng, Yihong Gao

Pinus massoniana needles extract androgenetic alopecia dihydrotestosterone hair regrowth follicular cycling oxidative stress immune pathways metabolic pathways apoptosis-related pathways flavonoids KRT14 IGF-1 TGF-β1 MAPK1 TNF PMNE AGA DHT

TLDR Pinus massoniana needles extract may help treat hair loss by promoting hair growth and reducing oxidative stress.

This study investigates the effects of Pinus massoniana needles extract (PMNE) on androgenetic alopecia (AGA) using a multiomics approach. In a dihydrotestosterone-induced mouse model, topical PMNE significantly promoted hair regrowth and improved follicular cycling, reducing oxidative stress and modulating immune, metabolic, and apoptosis-related pathways. Seventy-seven compounds, mainly flavonoids, were identified in PMNE. The treatment altered the expression of key markers like KRT14, IGF-1, and TGF-β1, and molecular docking suggested interactions with targets such as MAPK1 and TNF. These results suggest PMNE as a promising therapeutic agent for AGA by attenuating oxidative stress and influencing various molecular pathways.

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