Stem Cell-Based Strategies for Skin Regeneration and Repair: Current Approaches, Preclinical, and Clinical Evidence

Stem cell-based therapies show promise for skin regeneration and repair, addressing challenges like chronic wounds and burns. These therapies utilize various stem cell types, such as mesenchymal and hair follicle stem cells, to promote tissue repair through mechanisms like angiogenesis and immunomodulation. Preclinical and early clinical studies report positive outcomes for conditions like diabetic ulcers and alopecia. Advances in biomaterials and tissue engineering enhance these therapies' potential. However, challenges like standardization, scalability, and regulatory hurdles remain. Future research should focus on multicentre trials and standardized protocols to advance clinical application.