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GlossaryAdaptogen

Adaptogens are natural substances, often derived from plants, that help the body adapt to stress and promote homeostasis. In the context of hair loss, adaptogens may play a role in reducing stress-related hair shedding and supporting overall hair health by balancing hormonal levels and enhancing resilience to environmental stressors. Key distinguishing characteristics of adaptogens include their ability to normalize physiological functions and their non-specific action, meaning they can benefit various bodily systems rather than targeting a single issue.

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research Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

1 citations , February 2023 in “Drug Design Development and Therapy”

Plant adaptogens may help treat skin diseases and improve skin health, but more research is needed to fully understand how they work.

research Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages

268 citations , December 2003 in “Experimental Dermatology”

Hair follicle cells can become fat and bone cells.

research Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

research Cultured Cells from the Adult Human Hair Follicle Dermis can be Directed Toward Adipogenic and Osteogenic Differentiation

38 citations , April 2005 in “Journal of Investigative Dermatology”

Human hair follicle cells can become fat and bone cells, useful for therapy.

research Fluoxetine Decreases the Proliferation and Adipogenic Differentiation of Human Adipose-Derived Stem Cells

24 citations , July 2015 in “International Journal of Molecular Sciences”

Fluoxetine may help reduce fat by limiting stem cell growth and fat cell formation.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

20 citations , November 2020 in “Stem Cell Research & Therapy”

Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.

Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

research Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

11 citations , May 2015 in “Stem Cells Translational Medicine”

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

research DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages

8 citations , October 2020 in “Stem cell research & therapy”

DNMT1 helps turn hair follicle stem cells into fat cells by blocking a specific microRNA.

research Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow

6 citations , August 2020 in “Cell regeneration”

Hair follicle stem cells are similar to bone marrow stem cells but are better for fat cell research.

research Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies

4 citations , May 2023 in “Cells”

Baricitinib and its combination with lonafarnib improve fat cell formation in certain genetic disorders.

research YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2

2 citations , January 2025 in “动物学研究”

YAP1 helps fat cell formation by influencing the Hippo pathway.

research Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers

2 citations , November 2019 in “FEBS open bio”

Combining specific inducers helps dermal papilla cells regain hair-forming ability.

research Menopause and Dermal White Adipose Tissue Depletion: Mechanistic Links, Adipogenesis, and Regenerative Therapeutic Replacement

January 2026 in “Journal of Cosmetic Dermatology”

Menopause reduces skin fat, but treatments like magnolol and PLLA-SCA can help restore skin health.

research TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs

September 2025 in “Stem Cell Research & Therapy”

TAZ boosts fat cell formation in goat stem cells by activating a specific signaling pathway.

research Nelfb promotes dermal white adipose tissue formation through RNA Polymerase II mediated adipogenic gene regulation

September 2025 in “Development”

Nelfb is crucial for forming skin fat tissue by regulating genes needed for fat cell development.

research Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells

January 2025 in “Foods”

Mealworm protein helps fat cell development and may aid in metabolic health and hair growth.

research 570 Targeting phosphodiesterase 8A (PDE8A) to boost adipogenesis and hair regeneration

July 2024 in “Journal of Investigative Dermatology”

Inhibiting PDE8A may help treat hair loss by boosting fat cell growth and hair regeneration.

research Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells

April 2024 in “Applied biological chemistry”

Piperine from black pepper can make hair less oily by blocking fat cell development in hair roots.

Differentiation of Adipose-Derived Stem Cells by Stimulation with Extracellular Vesicles from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers

research Differentiation of Adipose Derived Stem Cells by Stimulating with Extracellular Vesicles Secreted from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers

September 2022 in “Institutional Repositories DataBase (IRDB)”

Adipose-derived stem cells can be transformed into hair-forming cells using specific extracellular vesicles, offering potential for hair regeneration therapies.

research Adipogenic Differentiation of Canine Hair Follicle Stem Cells (cHFSCs)

March 2022 in “Indian Journal of Animal Research”

Dog hair follicle stem cells can turn into fat cells.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

September 2020 in “Research Square (Research Square)”

Enhanced stem cells from the placenta can reduce fat buildup in eye tissue for Graves' disease.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

August 2020 in “Research Square (Research Square)”

Enhanced stem cells can reduce fat buildup in eye tissue for Graves' disease.

Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

June 2020

Enhanced stem cells from the placenta can reduce fat cell formation in eye disease.

research 0885 The androgen-THY1 axis mediates sexual dimorphism in dermal adipogenesis and fibrosis

July 2025 in “Journal of Investigative Dermatology”

Androgens reduce THY1 in skin cells, leading to less fat, more fibrosis, and worse healing in males.

research Nutraceuticals

7 citations , May 2021 in “Dermatologic Clinics”

Nutraceuticals like Ashwagandha and Astaxanthin may help with hair loss, but supplement regulation is challenging.

research Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

265 citations , March 1993 in “The EMBO Journal”

Keratinocyte growth factor significantly alters skin and tissue development.

research Intradermal adipocytes mediate fibroblast recruitment during skin wound healing

238 citations , March 2013 in “Development”

Fat cells help recruit healing cells and build skin structure during wound healing.

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Related Terms

Research

research Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

research Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages

research Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

research Cultured Cells from the Adult Human Hair Follicle Dermis can be Directed Toward Adipogenic and Osteogenic Differentiation

research Fluoxetine Decreases the Proliferation and Adipogenic Differentiation of Human Adipose-Derived Stem Cells

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

research Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

research DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages

research Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow

research Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies

research YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2

research Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers

research Menopause and Dermal White Adipose Tissue Depletion: Mechanistic Links, Adipogenesis, and Regenerative Therapeutic Replacement

research TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs

research Nelfb promotes dermal white adipose tissue formation through RNA Polymerase II mediated adipogenic gene regulation

research Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells

research 570 Targeting phosphodiesterase 8A (PDE8A) to boost adipogenesis and hair regeneration

research Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells

research Differentiation of Adipose Derived Stem Cells by Stimulating with Extracellular Vesicles Secreted from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers

research Adipogenic Differentiation of Canine Hair Follicle Stem Cells (cHFSCs)

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

research 0885 The androgen-THY1 axis mediates sexual dimorphism in dermal adipogenesis and fibrosis

research Nutraceuticals

research CLINICAL NUTRITION PROGRAM IMPROVES POST CONCUSSION SYMPTOMS IN 23 YEAR OLD FEMALE

research The Therapeutic Potential of Withania somnifera (Ashwagandha) in Non-Malignant Dermatological Conditions

research Butterfly pea flower: a captivating blue blossom with enchanted properties

research Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

research Intradermal adipocytes mediate fibroblast recruitment during skin wound healing