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GlossaryAdaptogen

Adaptogens are natural substances, often derived from plants, that help the body adapt to stress and promote homeostasis. In the context of hair loss, adaptogens may play a role in reducing stress-related hair shedding and supporting overall hair health by balancing hormonal levels and enhancing resilience to environmental stressors. Key distinguishing characteristics of adaptogens include their ability to normalize physiological functions and their non-specific action, meaning they can benefit various bodily systems rather than targeting a single issue.

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research Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

1 citations , February 2023 in “Drug Design Development and Therapy”

Plant adaptogens may help treat skin diseases and improve skin health, but more research is needed to fully understand how they work.

research Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages

268 citations , December 2003 in “Experimental Dermatology”

Hair follicle cells can become fat and bone cells.

research Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

research Cultured Cells from the Adult Human Hair Follicle Dermis can be Directed Toward Adipogenic and Osteogenic Differentiation

38 citations , April 2005 in “Journal of Investigative Dermatology”

Human hair follicle cells can become fat and bone cells, useful for therapy.

research Fluoxetine Decreases the Proliferation and Adipogenic Differentiation of Human Adipose-Derived Stem Cells

24 citations , July 2015 in “International Journal of Molecular Sciences”

Fluoxetine may help reduce fat by limiting stem cell growth and fat cell formation.

Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

research Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor

11 citations , May 2015 in “Stem Cells Translational Medicine”

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

research DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages

8 citations , October 2020 in “Stem cell research & therapy”

DNMT1 helps turn hair follicle stem cells into fat cells by blocking a specific microRNA.

research Comparative characterization and osteogenic / adipogenic differentiation of mesenchymal stem cells derived from male rat hair follicles and bone marrow

6 citations , August 2020 in “Cell regeneration”

Hair follicle stem cells are similar to bone marrow stem cells but are better for fat cell research.

research Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers

2 citations , November 2019 in “FEBS open bio”

Combining specific inducers helps dermal papilla cells regain hair-forming ability.

research Nelfb promotes dermal white adipose tissue formation through RNA Polymerase II mediated adipogenic gene regulation

September 2025 in “Development”

Nelfb is crucial for forming skin fat tissue by regulating genes needed for fat cell development.

research Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells

January 2025 in “Foods”

Mealworm protein helps fat cell development and may aid in metabolic health and hair growth.

Differentiation of Adipose-Derived Stem Cells by Stimulation with Extracellular Vesicles from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers

research Differentiation of Adipose Derived Stem Cells by Stimulating with Extracellular Vesicles Secreted from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers

September 2022 in “Institutional Repositories DataBase (IRDB)”

Adipose-derived stem cells can be transformed into hair-forming cells using specific extracellular vesicles, offering potential for hair regeneration therapies.

research Adipogenic Differentiation of Canine Hair Follicle Stem Cells (cHFSCs)

March 2022 in “Indian Journal of Animal Research”

Dog hair follicle stem cells can turn into fat cells.

research Nutraceuticals

7 citations , May 2021 in “Dermatologic Clinics”

Nutraceuticals like Ashwagandha and Astaxanthin may help with hair loss, but supplement regulation is challenging.

research The Therapeutic Potential of Withania somnifera (Ashwagandha) in Non-Malignant Dermatological Conditions

July 2025 in “SKIN The Journal of Cutaneous Medicine”

Ashwagandha may help with skin and hair issues, but more research is needed.

research Butterfly pea flower: a captivating blue blossom with enchanted properties

February 2025 in “International Journal of Research Publication and Reviews”

Butterfly pea flower is valued for its health benefits, color-changing ability, and use in food and drinks.

research Adipocytes in Skin Health and Disease

77 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

research Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

75 citations , October 2016 in “Genes & Development”

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

Body Composition Changes and Inhibition of Fat Development In Vivo Implicate Androgen in Regulation of Stem Cell Lineage Allocation

research Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation

37 citations , June 2011 in “Journal of Cellular Biochemistry”

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

research Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold

29 citations , April 2020 in “Biomolecules”

The 3D scaffold helped maintain hair cell traits and could improve hair loss treatments.

research Dermal papilla cells induce keratinocyte tubulogenesis in culture

28 citations , March 2010 in “Histochemistry and cell biology”

Skin cells can help create early hair-like structures in lab cultures.

research BMP2-mediated PTEN enhancement promotes differentiation of hair follicle stem cells by inducing autophagy

24 citations , September 2019 in “Experimental cell research”

BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

research Biological Features Implies Potential Use of Autologous Adipose-Derived Stem/Progenitor Cells in Wound Repair and Regenerations for the Patients with Lipodystrophy

23 citations , November 2019 in “International Journal of Molecular Sciences”

Adipose-derived stem cells can help repair tissue in lipodystrophy patients.

research Repeal and Replace: Adipocyte Regeneration in Wound Repair

22 citations , April 2017 in “Cell Stem Cell”

Skin wounds can create fat cells that help regenerate hair follicles, with BMP signaling playing a crucial role in this process.

Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration

research Pro-Insulin-Like Growth Factor-II Ameliorates Age-Related Inefficient Regenerative Response by Orchestrating Self-Reinforcement Mechanism of Muscle Regeneration

19 citations , April 2015 in “Stem Cells”

Pro-IGF-II improves muscle repair in old mice.

Targeting Evasion of Immune Pathways in Glioblastoma

research TLRgeting Evasion of Immune Pathways in Glioblastoma

15 citations , April 2017 in “Cell Stem Cell”

Some brain cancer cells avoid immune system detection, and certain treatments could target this to slow their growth; also, certain fat cell precursors help regenerate hair and skin after injury.

Enhanced Viability and Neural Differentiation Potential in Poor Post-Thaw Human Adipose-Derived Stem Cells by Agarose Multi-Well Dishes and Spheroid Culture

research Enhanced viability and neural differential potential in poor post-thaw hADSCs by agarose multi-well dishes and spheroid culture

15 citations , June 2015 in “Human Cell”

Spheroid culture in agarose dishes improves survival and nerve cell growth in thawed human fat-derived stem cells.

research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

7 citations , January 2022 in “Biomedicines”

Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.

research Activating the healing process: three-dimensional culture of stem cells in Matrigel for tissue repair

5 citations , May 2024 in “BMC Biotechnology”

Using Matrigel with stem cells improves tissue healing.

research DERMAL ADIPOSE TISSUE IN HAIR FOLLICLE CYCLING: POSSIBLE APPLICATIONS IN ALOPECIA?

2 citations , April 2017 in “PubMed”

Fat cells near hair follicles may affect hair growth and could help treat baldness.