January 2018 in “Springer eBooks” Alopecia totalis/universalis is a severe form of hair loss where all body hair is lost.
146 citations
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July 2003 in “Journal of the American Academy of Dermatology” Clobetasol propionate ointment can help some people with total hair loss regrow hair.
11 citations
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January 2018 in “Acta dermato-venereologica” Tofacitinib works better and is more tolerable for severe alopecia than conventional treatments and DPCP immunotherapy.
3 citations
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November 2021 in “World Journal of Clinical Pediatrics” Vitamin D might help treat some types of hair loss, but more research is needed.
2 citations
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July 1998 in “International Journal of Dermatology” We need a safe, reliable way to stop severe hair loss.
130 citations
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February 2018 in “Journal of Investigative Dermatology” Tofacitinib may help treat severe hair loss, but more research is needed.
44 citations
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April 2017 in “International Journal of Dermatology” No treatment is completely effective for alopecia totalis and alopecia universalis.
36 citations
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March 1989 in “British journal of dermatology/British journal of dermatology, Supplement” DPCP is more effective than tretinoin gel for treating severe alopecia.
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September 2024 in “The Journal of Dermatology” Ritlecitinib helps regrow hair in people with alopecia totalis and universalis and is safe to use.
5 citations
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May 2015 in “The Journal of Dermatology” Topical corticosteroids can help treat severe alopecia areata when other treatments fail.
2 citations
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January 2019 in “Dermatology Review” Pigmented vellus and upright regrowing hairs predict hair regrowth in severe alopecia.
September 2025 in “Journal of the Pakistan Medical Association” Tofacitinib effectively and safely promotes hair regrowth in alopecia patients.
July 2025 in “Frontiers in Medicine” Topical immunotherapy can help with severe hair loss, but results vary and need personalized, long-term treatment.
November 2023 in “Indian Dermatology Online Journal” Tofacitinib was effective for severe, treatment-resistant hair loss without side effects.
January 2016 in “Hair therapy & transplantation” Hair UpTM effectively and safely promotes hair regrowth, especially in minors.
105 citations
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December 1995 in “British journal of dermatology/British journal of dermatology, Supplement” PUVA treatment is generally ineffective for alopecia areata.
75 citations
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March 2023 in “JAMA Dermatology” Alopecia areata and its severe forms are becoming more common, especially among females, adults, and people in the Northeast.
49 citations
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May 2018 in “Journal of the American Academy of Dermatology” Applying 2% tofacitinib cream helped some children with severe hair loss grow back hair.
39 citations
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April 2003 in “Australasian journal of dermatology” PUVA treatment led to significant hair regrowth in over half of the patients with alopecia areata totalis and universalis.
38 citations
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January 2012 in “Journal of Korean Medical Science” Early-onset alopecia, especially with a family history, leads to worse outcomes and more related health issues.
1 citations
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March 2012 in “Journal of the American Academy of Dermatology” Botulinum toxin A injections may help treat difficult cases of total hair loss.
November 2025 in “Journal of Cutaneous Medicine and Surgery” JAK inhibitors are effective and safe for treating severe alopecia areata.
January 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” Botulinum toxin type A did not help regrow hair in severe alopecia cases.
Tofacitinib significantly regrows hair in severe alopecia without major side effects.
3 citations
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July 2023 in “International Journal of Trichology” 78 citations
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July 1984 in “Journal of Investigative Dermatology” 69 citations
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December 2006 in “Archives of dermatology” Adalimumab may cause severe hair loss in some patients.
28 citations
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October 1978 in “Archives of dermatology” Corticosteroids may effectively regrow hair in Alopecia Totalis with manageable side effects.
5 citations
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January 2010 in “International journal of trichology” PUVASOL might effectively treat complete scalp baldness.
5 citations
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July 1988 in “British journal of dermatology/British journal of dermatology, Supplement” Diphencyprone therapy can effectively treat severe hair loss in motivated patients.