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GlossaryAnagen Hair Follicles

phase where hair actively grows

Anagen hair follicles, also known as growing hair follicles or active hair follicles, are in the phase of the hair growth cycle where the hair is actively growing. This phase can last anywhere from 2 to 7 years, during which the hair shaft is continuously produced by the follicle, resulting in longer hair. This is the most prolonged phase of the hair cycle and is crucial for determining the length of the hair.

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Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

130 citations , January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

research Prostanoid receptors in anagen human hair follicles

39 citations , November 2007 in “Experimental dermatology”

Human hair follicles contain a complex network of prostanoid receptors that may influence hair growth.

research Abnormal inner root sheath of the hair follicle in the loose anagen hair syndrome: An ultrastructural study

31 citations , December 2010 in “Journal of the American Academy of Dermatology”

Loose anagen hair syndrome is caused by structural abnormalities in the hair follicle's inner root sheath.

Ephrin-A3 Increases Hair Follicle Density and Accelerates Anagen Development in Neonatal Mice

research Ephrin-A3 not only increases the density of hair follicles but also accelerates anagen development in neonatal mice

15 citations , July 2008 in “Journal of Dermatological Science”

Ephrin-A3 helps increase and speed up hair growth in baby mice.

research Structural optimization of pep7, a small peptide extracted from epimorphin, for effective induction of hair follicle anagen

9 citations , August 2005 in “Experimental Dermatology”

Modified pep7, named EPM peptide, effectively promotes hair growth at low concentrations and works well with minoxidil.

research Locations of synthesis of hair structural proteins in human anagen follicles

7 citations , April 1996 in “British Journal of Dermatology”

Hair structural proteins are synthesized sequentially in specific cells, offering a new way to study hair proteins and defects.

research Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis

7 citations , August 2020 in “Genes”

Different genes are active in dogs' hair growth and skin, similar to humans, which helps understand dog skin and hair diseases and can relate to human conditions.

In Vitro Methodology, Hormonal and Nutritional Effects, and Fiber Production in Isolated Ovine and Caprine Anagen Hair Follicles

research In vitro methodology, hormonal and nutritional effects and fibre production in isolated ovine and caprine anagen hair follicles

7 citations , January 2010 in “Animal”

Angora goat hair grows faster and produces more protein than cashmere goat hair, and certain hormones and nutrients positively affect hair growth and protein synthesis.

research Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue

6 citations , January 2023 in “npj regenerative medicine”

Transplanting growing hair follicles into scars can help regenerate and improve scar tissue.

Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

research Oral Spermidine Supplementation Prolongs Hair Follicle Anagen Phase with Sustained Effects: A Randomized, Double-Blind, Placebo-Controlled Trial

January 2025 in “MEDS Public Health and Preventive Medicine”

Spermidine supplements can help extend the hair growth phase and may be useful for treating hair loss.

research An estrogen receptor pathwayregulates thetelogen-anagen hair follicle transition andinfluences epidermal cell proliferation (epidermis/estrogen/keratinocyte/differentiation/mesenchymal

January 1996

The estrogen receptor pathway controls hair growth cycles and affects skin cell growth.

research Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research PDGF isoforms induce and maintain anagen phase of murine hair follicles

136 citations , June 2006 in “Journal of Dermatological Science”

PDGF isoforms can promote and sustain hair growth.

research Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture

132 citations , September 2009 in “Experimental Dermatology”

A reliable system was developed to distinguish hair growth stages, aiding in identifying hair growth promoters or inhibitors.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Peptidylarginine Deiminase Isoforms Are Differentially Expressed in the Anagen Hair Follicles and Other Human Skin Appendages

71 citations , June 2005 in “Journal of Investigative Dermatology”

PAD enzymes play a key role in hair growth and structure.

research Identification of microRNAs in Wool Follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep

37 citations , October 2013 in “PLoS ONE”

MicroRNAs play a key role in wool growth in Tibetan sheep.

research Expression of the Orphan Protein Plet-1 during Trichilemmal Differentiation of Anagen Hair Follicles

30 citations , February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Plet-1 protein helps hair follicle cells move and stick to tissues.

research Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo

25 citations , June 2004 in “Journal of Investigative Dermatology”

Macrophage-stimulating protein helps hair grow and can start hair growth phase in mice and human hair samples.

research Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

lncRNAs play a key role in hair follicle development, affecting cashmere quality and yield.

research NF-κB Activity Is Required for Anagen Maintenance in Human Hair Follicles In Vitro

15 citations , February 2014 in “Journal of Investigative Dermatology”

NF-κB activity is crucial for keeping hair in the growth phase.

research Interleukin 6 induces the hair follicle growth phase (anagen)

12 citations , June 2006 in “Journal of Dermatological Science”

Interleukin 6 helps hair grow.

research Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development

10 citations , May 2020 in “Frontiers in cell and developmental biology”

MicroRNAs are important for hair growth regulation, with Dicer being crucial and Tarbp2 less significant.

research IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles

9 citations , August 2023 in “Journal of Investigative Dermatology”

IL-15 helps hair grow longer and stronger by extending the growth phase and reducing cell death.

research 551 Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers made a detailed map of gene activity for different parts of human hair follicles to help create targeted hair disorder treatments.

research Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles

28 citations , November 2012 in “Experimental dermatology”

A protein complex called mTORC1 likely affects when hair growth starts in mice.

research Immunization by Application of DNA Vaccine onto a Skin Area Wherein the Hair Follicles Have Been Induced into Anagen-onset Stage

20 citations , August 2007 in “Molecular therapy”

Applying a DNA vaccine to skin with active hair growth boosts immune response and protection against anthrax in mice.

research Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus)

14 citations , January 2015 in “Genetics and molecular research”

The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.

research TGF‐β and HSP70 profiles during transformation of yak hair follicles from the anagen to catagen stage

10 citations , February 2019 in “Journal of cellular physiology”

TGF-β2 helps yak hair follicles enter the regression phase, while HSP70 tries to prevent it.

research Construction of transcriptome atlas of white yak hair follicle during anagen and catagen using single-cell RNA sequencing

8 citations , December 2022 in “BMC Genomics”

The research improved understanding of yak hair growth to help use yak wool better.