100 citations
,
September 2017 in “Molecular and Cellular Endocrinology” Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.
43 citations
,
April 2011 in “AJP Endocrinology and Metabolism” Androgens increase muscle mass by promoting myoblast growth through ornithine decarboxylase.
2 citations
,
October 2020 in “Annals of Oncology” Androgen deprivation therapy might help prevent severe COVID-19, but more research is needed.
October 2022 in “Biomedicines” Finasteride in male rats causes liver and metabolic issues in their offspring.
5 citations
,
January 2024 in “Reproductive Medicine and Biology” Androgen and Wnt signals are crucial for developing and functioning male genitalia and erectile tissues.
August 2024 in “Steroids” The androgen receptor's shape-changing ability helps it function but can lead to cancer treatment resistance.
August 2019 in “Carolina Digital Repository (University of North Carolina at Chapel Hill)” DHT enhances androgen receptor activity more than testosterone, and MAGE-11 influences this activity through specific interactions.
104 citations
,
December 2004 in “Journal of Neurochemistry” Androgens help motor neurons grow by increasing neuritin.
93 citations
,
June 2001 in “The Journal of Clinical Endocrinology and Metabolism” Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.
51 citations
,
August 2012 in “Differentiation” Mouse genital development depends on male or female hormones for specific features.
18 citations
,
February 2018 in “International Journal of Molecular Sciences” PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.
13 citations
,
May 1998 in “The Journal of Clinical Endocrinology & Metabolism” LH and hCG reduce certain protein levels in women's skin.
1 citations
,
March 2025 in “Medical Molecular Morphology” Androgens affect the function and health of the endometrium.
Androgens increase norepinephrine release, promoting smooth muscle growth in male sex organs, which may contribute to benign prostatic hypertrophy.
123 citations
,
May 2020 in “Drug Development Research” Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.
December 2025 in “International Journal of Infertility & Fetal Medicine” Metformin helps treat PCOS by improving fertility, reducing symptoms, and regulating periods.
14 citations
,
September 2006 in “Experimental Dermatology” Interleukin‐1 α reduces androgen receptor levels and increases certain cytokines in human scalp cells.
66 citations
,
January 2001 in “Vitamins and hormones” Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.
26 citations
,
April 2007 in “Journal of pediatric gastroenterology and nutrition” A teenage girl with high androgen levels and PCOS developed a rare liver tumor, suggesting a possible link between high androgens and the tumor's growth.
July 2025 in “Medical Science” Anabolic steroids and SARMs can cause serious liver damage.
1231 citations
,
May 2001 in “Hypertension” Men generally have higher blood pressure than premenopausal women, but postmenopausal women's blood pressure can surpass men's, and hormone therapy doesn't significantly help.
24 citations
,
October 2012 in “The International Journal of Biochemistry & Cell Biology” Testosterone protects female heart cells from stress by activating estrogen receptors.
November 2016 in “Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)” The VMH AMPK-SNS-BAT axis may help treat cachexia and obesity.
56 citations
,
February 2006 in “American journal of physiology. Cell physiology” Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
February 2014 in “Revista Argentina de Cardiología” Androgens may increase arrhythmias in Brugada Syndrome, while Finasteride could reduce them.
August 2013 in “Nature Reviews Drug Discovery” New cancer treatments show promise in reducing tumor growth and improving skin regeneration in mice.
August 2013 in “Nature Reviews Drug Discovery” New treatments may restore cancer-blocking proteins, slow prostate cancer, identify drug targets, and potentially regrow hair.
December 2015 in “Вестник дерматологии и венерологии” Men with male pattern baldness may not have different hormone levels, but their hair follicles are likely more sensitive to hormones.
108 citations
,
April 2004 in “Medicinal Research Reviews” Steroid sulfatase inhibitors could help treat hormone-related disorders and cancers.
August 2025 in “Al-Salam Journal for Medical Science” Steroid hormones are vital for body functions and disease management.