August 2026 in “Cosmetics” The scoping review evaluates the effectiveness of biotics—prebiotics, probiotics, synbiotics, postbiotics, and paraprobiotics—in treating acne-prone skin and scalp disorders by modulating the skin microbiome. It includes 66 studies and highlights that multi-strain and synbiotic formulations show strong evidence for reducing inflammation. Notable findings include a synbiotic reducing acne lesions by 56.67% in an 8-week RCT with 114 participants, and oral Lacticaseibacillus paracasei ST11 reducing dandruff by 70% compared to 23% with placebo. Additionally, a mixture of Lacticaseibacillus rhamnosus and Bifidobacterium longum improved alopecia areata by 56% versus 30% in a 24-week study with 26 participants. Despite promising results, challenges such as formulation stability, strain specificity, and regulatory heterogeneity persist, necessitating larger, standardized RCTs with active comparators. The review emphasizes the potential of biotics as adjunctive treatments for acne and scalp disorders, but further research is needed to optimize their use in dermatological applications.
12 citations
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June 2025 in “Gut Microbes” BroadAMP-GPT effectively creates antimicrobial peptides to fight drug-resistant bacteria.
2 citations
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January 2002 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” Sophora flavescens extract helps hair grow and prevents acne.
Aloe vera hair tonic with 10% and 15% concentrations effectively promoted hair growth in male rats.
February 2026 in “Food Research International” Lactiplantibacillus plantarum ZJUIDS51 can help regrow hair and improve scalp health in androgenic alopecia.
1 citations
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December 2022 in “Journal of applied biological chemistry” TRP-hair essence protects hair from heat damage, maintains color, and strengthens hair.
1 citations
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April 2022 in “Applied sciences” Bitter melon extract may help prevent hair loss and can be used in cosmetic products.
17 citations
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August 2012 in “Archives of Pharmacal Research” Acankoreoside J from Acanthopanax koreanum may help promote hair growth.
January 2006 in “Journal of Liaoning University of Petroleum & Chemical Technology” 
23 citations
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January 2012 in “International Food Research Journal” Tofacitinib effectively treated a woman's severe symptoms from a rare autoimmune condition.
305 citations
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July 2016 in “International Journal of Biological Macromolecules” Polysaccharides have many health benefits and are used in drugs, but isolating and purifying them is complex and requires careful methods.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” Ficus platyphylla leaf extract is likely safe in high doses, with minor temporary side effects.
5 citations
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August 2018 Plant extracts can benefit skin but must be safe and high-quality.
March 2025 in “Jurnal Farmamedika (Pharmamedica Journal)” Procyanidin from Indonesian spices may help heal diabetic wounds.
May 2023 in “Jurnal Penelitian Farmasi & Herbal” Cucumber hair tonic formulations are stable and may help with hair loss.
April 2016 in “Journal of Investigative Dermatology” Oenocarpus bataua vegetable oil may help reduce hair loss by affecting a key gene pathway.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” Biochanin A from soy is a promising and safe candidate for treating hair loss.
14 citations
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June 2024 in “Food Chemistry X” Pomegranate leaf shows promise for health benefits, but more human trials are needed.
June 2025 in “Jundishapur Journal of Natural Pharmaceutical Products” Pomelo peel essential oil can be efficiently extracted and meets quality standards for use in pharmaceuticals and cosmetics.
CDPDFM can improve acne symptoms in rabbit ears.
January 2026 in “Food and Nutrition Sciences” USPlus PRO saw palmetto extract improves urinary symptoms and is safe for men.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” Ficus platyphylla leaf extract is likely safe in high doses for rats.
The nanoemulsions effectively promoted hair growth in male rats.
September 2025 in “International Journal for Research in Applied Science and Engineering Technology” Guava leaf extracts are beneficial for skin, hair, and oral care.
December 2008 in “Enzyme and Microbial Technology” New patents include innovations in skin and hair care, disease treatment, plant stress tolerance, and protein purification.
April 2026 in “Trends in Sciences” Acanthus ebracteatus extract in a microemulsion can promote hair growth and is stable for use as a hair tonic.
September 2025 in “Plants” Juniperus morrisonicola wood essential oil has strong anti-inflammatory and antifungal properties.
282 citations
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April 2007 in “Journal of Agricultural and Food Chemistry” Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.
February 2018 in “Zenodo (CERN European Organization for Nuclear Research)” High doses of Lagenaria siceraria fruit powder lower FSH and LH hormone levels in male rats.
March 2025 in “Journal of Science Natural Science” Acetyl tetrapeptide-3 was successfully made for use in hair loss treatments.