24 citations
,
February 2007 in “Laser Physics Letters” Caffeine shampoo penetrates hair follicles deeply and stays for up to 48 hours.
21 citations
,
September 1966 in “Toxicology and Applied Pharmacology” Caffeine becomes more toxic in rats when food intake is reduced by over 50%.
15 citations
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June 1996 in “Journal of Pharmacy and Pharmacology” Caffeine levels in hair and blood can indicate liver health.
10 citations
,
July 2021 in “European journal of pharmaceutics and biopharmaceutics” Nanoparticles sized between 470 and 750 nm are best for delivering substances like caffeine into hair follicles for absorption.
8 citations
,
April 2020 in “European Journal of Nutrition” Newborns' hair shows how much caffeine their mothers drank during pregnancy.
7 citations
,
January 2020 in “Skin Pharmacology and Physiology” Standard nail varnish effectively prevents follicular penetration of certain substances.
4 citations
,
February 2022 in “Journal of Pharmaceutical and Biomedical Analysis” The conclusion is that a new method can measure caffeine and drugs in hair, finding caffeine abusers have 70 times more caffeine than normal, with a proposed cut-off value for abuse.
4 citations
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September 1999 in “Journal of Clinical Forensic Medicine” Caffeine in hair might help identify people, but it's not always reliable.
2 citations
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January 2022 in “Materials today: proceedings” Caffeine may be good for hair growth and skin care because it binds well with keratin.
1 citations
,
August 2020 in “British Journal of Dermatology” Caffeine may protect hair follicles from stress-related hair loss.
January 2026 in “AAPS PharmSciTech” Liposomal formulations with caffeine and cafestol enhance skin penetration effectively.
January 2024 in “Indonesian Journal of Pharmaceutical Education” The Caffein Herbasome® cream is stable and suitable for skin use.
September 2023 in “Journal of The American Academy of Dermatology” Caffeine may help hair grow better.
December 2020 in “Journal of Cosmetic Science” The caffeine content in anticellulite gels is 0.7-1.7% and in hair-care products is about 1.0%.
Nanoparticles with caffeine can be used for slow, continuous hair growth stimulation.
May 2025 in “International Journal of Innovative Technologies in Social Science” Caffeine causes sleep problems in many medical students.
Caffeine in Alpecin shampoo may help prolong hair root activity and reduce hair loss.
5 citations
,
October 2020 in “Giornale italiano di dermatologia e venereologia” The phyto-caffeine shampoo reduced hair loss and improved hair strength in women with hair thinning.
94 citations
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May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles greatly increase caffeine absorption through the skin shortly after it's applied.
61 citations
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May 2014 in “International journal of pharmaceutics” Nanocrystals improve skin penetration and stability of caffeine, suggesting a new method for delivering similar substances through the skin.
42 citations
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July 2014 in “European journal of pharmaceutics and biopharmaceutics” Caffeine nanocrystals for skin products stay stable with the right stabilizer, but grow in size at higher temperatures.
12 citations
,
March 2012 in “ATLA. Alternatives to laboratory animals” Hair follicles significantly affect the skin absorption of some drugs.
2 citations
,
January 2016 Optimized formulations with specific ingredients can significantly improve skin delivery of topical drugs.
2 citations
,
January 2012 in “International Journal of Trichology” Coffee and tea might help hair growth in balding individuals, but side effects and alternative uses are being considered.
2 citations
,
January 2014 Improved methods create smaller, more effective gelatin nanoparticles for skin delivery, and new caffeine nanocrystals enhance absorption and effectiveness.
1 citations
,
March 2022 in “Protection convergence” Fermented green coffee beans may be good for scalp and hair health cosmetics.
September 2025 in “medRxiv (Cold Spring Harbor Laboratory)” Using Centella asiatica EV and growth factors improves scalp health and hair growth.
January 2024 in “Estetologia Medyczna i Kosmetologia” Most hair loss shampoos have unproven active ingredients.
June 2023 in “Journal of Pharmaceutical and Health Research” Caffeine hair tonic with 0.001% concentration was more effective in promoting hair growth on guinea pigs.