research Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer
Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.
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research The Genetic Landscape of Androgenetic Alopecia: Current Knowledge and Future Perspectives
Androgenetic alopecia is influenced by multiple genes and pathways, with genetic risk varying by population, and personalized treatments are being explored.
research A network pharmacology-based approach to explore mechanism of action of medicinal herbs for alopecia treatment
Medicinal herbs might treat hair loss by affecting genes and pathways related to lipid and glycerophospholipid metabolism.
research Unraveling the Molecular Mechanism of Bider Marking Formation in Dun Mongolian Horses Through Transcriptome Sequencing
"Bider" markings in Dun Mongolian horses are caused by a complex network of genes and pathways.
research Orchestration of tissue‐scale mechanics and fate decisions by polarity signalling
Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
research Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner
Nε-(carboxymethyl) lysine delays hair growth by blocking a key protein.
research Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis
Lhx2 is essential for effective Sonic Hedgehog signaling in early retinal development.
research TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network
TTNPB helps turn stem cells into neural stem cells, improving depression-like behaviors in rats.
research Regulation of stem cell function by protein ubiquitylation
Protein ubiquitylation is crucial for controlling stem cell functions and could be targeted for cancer treatment.
research Gynostemma pentaphyllum Makino extract induces hair growth and exhibits an anti‐graying effect via multiple mechanisms
Gynostemma pentaphyllum extract may help grow hair and prevent graying.
research Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development
MicroRNAs are important for hair growth regulation, with Dicer being crucial and Tarbp2 less significant.
research Fibroblast Growth Factor-7 and Hair Biology: Bridging Basic Science and Therapeutic Applications
FGF-7 helps hair grow by activating hair follicles and is a promising target for hair loss treatments.
research 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line
Y27632 increases cell growth through EGFR signaling, not ROCK1/2.
research Shedding light on cashmere goat hair follicle biology: from morphology analyses to transcriptomic landascape
The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.
research Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
research Cell fate decisions: emerging roles for metabolic signals and cell morphology
Metabolic signals and cell shape influence how cells develop and change.
research Runx3 is involved in hair shape determination
Runx3 helps determine hair shape.
research Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis
Activating Notch signaling can kill basal cell carcinoma cells.
research Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation
Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.
research Minoxidil ameliorates myelodysplastic syndrome by targeting Wnt4 while sparing normal hematopoiesis
Minoxidil may help treat myelodysplastic syndrome without harming normal blood cell production.
research Bioinspired engineering of Polygonum multiflorum root nanovesicles regulates dermal papilla cells in vitro and stimulates human hair follicle growth ex vivo
Polygonum multiflorum root nanovesicles may help hair growth and treat hair loss.
research Research Advances in Therapeutic Strategies and Drug Delivery Systems for Pathological Scars
New drug delivery systems show promise in effectively treating pathological scars.
research PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence
PIEZO1 helps keep hair follicle stem cells inactive, affecting hair growth.
research Identification of N6-Methyladenosine-Related Factors and the Prediction of the Regulatory Mechanism of Hair Follicle Development in Rex and Hycole Rabbits
N6-methyladenosine affects hair follicle development differently in Rex and Hycole rabbits.
research Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation
Advancements in wound healing aim to improve personalized treatments and enhance healing outcomes.
research Pathological Skin Scarring: From Mechanism to Targeted Local Therapy
Pathological skin scarring, including hypertrophic scars and keloids, arises from dysregulated wound healing processes involving excessive inflammation and mechanical tension, leading to fibroblast differentiation and disorganized collagen deposition. The review identifies key signaling pathways, such as TGF-β/Smad and TNF-α/NF-κB, as therapeutic targets and highlights a novel treatment using atorvastatin delivered via a keratin hydrogel derived from human hair. This approach offers a sustainable, localized anti-fibrotic therapy. Combination therapies are suggested to be more effective than monotherapies, although recurrence remains a challenge. The document also discusses genetic predispositions, various current treatments, and emphasizes the need for further research to optimize therapies for scar-free healing.
research Conditional telomerase induction causes proliferation of hair follicle stem cells
Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.
research Integrated Analysis of Methylome and Transcriptome Changes Reveals the Underlying Regulatory Signatures Driving Curly Wool Transformation in Chinese Zhongwei Goats
PDGFC gene may help select goats with desirable curly wool traits.
research Gene expression profiling of intestinal regeneration in the sea cucumber
Sea cucumbers have unique genes that help them regenerate their intestines.
research Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma
Overactive signaling in hair follicles can lead to skin cancer.