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GlossaryCaspase

enzymes that trigger cell death by cutting specific proteins

Caspases are a family of enzymes that play a crucial role in programmed cell death, also known as apoptosis. They act like molecular scissors, cutting specific proteins in the cell to trigger a cascade of events leading to cell dismantling and removal, which is essential for maintaining healthy tissue and organ function.

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research Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt

83 citations , October 2012 in “International Journal of Oncology”

Wedelolactone selectively kills prostate cancer cells without harming normal cells.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations , July 2015 in “Journal of Immunology”

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis

28 citations , September 1998 in “Journal of Investigative Dermatology”

Two distinct caspases in human skin help with cell death and skin formation.

research Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia

27 citations , March 2012 in “Dermatologic Surgery”

Higher caspase-1 levels found in balding scalps; reducing it may help treat hair loss.

research Distribution of caspase‐14 in epidermis and hair follicles is evolutionarily conserved among mammals

21 citations , September 2005 in “The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology/Anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology”

Caspase-14 is important for skin and hair development in all mammals.

research The concealed side of caspases: beyond a killer of cells

13 citations , December 2024 in “Cellular and Molecular Life Sciences”

Caspases do more than kill cells; they also help in cell growth and disease, and targeting them could lead to new treatments.

research Exploring caspase functions in mouse models

8 citations , June 2024 in “APOPTOSIS”

Caspases affect many cell functions and could help treat various diseases.

Caspases in Life and Death: Their Role in Head Formation

research Making the head: Caspases in life and death

7 citations , January 2023 in “Frontiers in Cell and Developmental Biology”

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

Non-Apoptotic Role for Caspase-7 in Hair Follicles and Surrounding Tissue

research Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

6 citations , August 2015 in “Journal of Molecular Histology”

Caspase-7 has functions in skin and hair that are not related to cell death.

research Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata

5 citations , September 2024 in “Biomolecules and Biomedicine”

Total glucosides of paeony may help treat alopecia areata by reducing inflammation and hair loss.

research Extracellular Caspase-1 induces hair stem cell migration in wounded and inflamed skin conditions

4 citations , April 2024 in “The Journal of Cell Biology”

Caspase-1 helps hair stem cells move to heal wounded or inflamed skin.

research Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12

4 citations , June 2015 in “Connective tissue research”

The research found changes in gene expression related to cell death in mouse skin that help understand hair follicle development and skin health.

research Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series

2 citations , April 2023 in “American Journal of Dermatopathology”

CCCA may involve the PD1/PDL1 pathway and increased caspase 3, leading to permanent hair loss.

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis

June 2025 in “Phytomedicine”

The formula may improve hair growth and health by boosting blood flow and reducing cell stress.

research <b>Platelet-rich plasma improves caspase-3 of skin graft treated with Tilapia Mozambique bio-dressing</b>

January 2025 in “Open Veterinary Journal”

PRP with TM bio-dressing improves skin graft healing in cats.

research Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development

19 citations , February 2013 in “Archives of Dermatological Research”

Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

research Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death

January 2022 in “International Journal of Medical Sciences”

Cedrol may be an effective treatment for colorectal cancer.

research Cell death by cornification

375 citations , June 2013 in “Biochimica et biophysica acta. Molecular cell research”

Cornification is how skin cells die to form the protective outer layer of skin, hair, and nails.

research Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo andIn Vitro

140 citations , December 1998 in “Journal of Investigative Dermatology”

Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.

research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

58 citations , January 2006 in “Skin Pharmacology and Physiology”

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

research Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.

Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

research Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis

46 citations , March 2019 in “Journal of Pineal Research”

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

research Inhibition of CCAAT/Enhancer Binding Protein Family DNA Binding in Mouse Epidermis Prevents and Regresses Papillomas

28 citations , February 2007 in “Cancer Research”

Blocking certain proteins in mouse skin can reduce and shrink skin tumors.

research Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia

28 citations , December 2001 in “European Journal of Pharmacology”

M50054 may help treat hepatitis and hair loss from chemotherapy.