June 2026 in “Saudi Medical Horizons Journal” Janus kinase (JAK) inhibitors are a promising treatment for inflammatory and autoimmune skin diseases like atopic dermatitis, alopecia areata, and vitiligo, due to their ability to target the disrupted JAK-STAT signaling pathway. Clinical research supports the effectiveness of both topical and oral JAK inhibitors, such as ruxolitinib cream and oral agents like abrocitinib, baricitinib, and upadacitinib, in reducing inflammation and itching in atopic dermatitis. For alopecia areata, baricitinib, ritlecitinib, and deuruxolitinib offer hope for severe cases. In vitiligo, topical ruxolitinib shows potential in restoring facial pigment. While generally well-tolerated, these treatments require ongoing safety monitoring due to risks like infections and cardiovascular issues. The review emphasizes the need for further research to enhance long-term safety and patient selection.
88 citations
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December 2003 in “Journal of Biological Chemistry” Epiprofin helps cells grow in developing teeth, hair, and limbs.
1 citations
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January 2020 in “Journal of Crohn's and colitis” Many people with inflammatory bowel disease have a vitamin C deficiency, which can lead to scurvy symptoms.
March 2026 in “SKIN The Journal of Cutaneous Medicine” Ritlecitinib is being tested for safety and effectiveness in young children with severe alopecia areata.
5 citations
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July 1999 in “Journal of Anatomy” Methylene blue staining effectively highlights detailed nerve structures in rat fur.
21 citations
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October 2013 in “Molecular Biology of the Cell” The protein CCN2 controls hair growth by affecting hair follicle formation and stem cell activity in mice.
The study identified a key protein involved in producing underarm odor and found ways to inhibit it.
20 citations
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December 2010 in “Journal of Morphology” Lizard claws have hair-like keratins similar to those in mammals.
3 citations
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May 2019 in “Journal of Cosmetic Dermatology” Pro-Ile could be used in cosmetics to improve skin, hair growth, and healing.
September 2023 in “Research Square (Research Square)” TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.
May 2011 in “Value in Health” CP-690,550 significantly reduced itching in patients with moderate-to-severe plaque psoriasis.
10 citations
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July 2023 in “Pharmaceuticals” The gel with coral extract and pectin nanoparticles helps heal chronic wounds.
21 citations
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October 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.
3 citations
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May 2018 in “Psychiatry and Clinical Psychopharmacology” N-acetylcysteine may help treat trichotillomania.
Par3–mInsc and Gαi3 work together to ensure proper cell division orientation in skin development.
10 citations
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July 2019 in “Advances in Wound Care” Reducing Flightless I protein improves wound healing by activating skin stem cells.
August 2019 in “Journal of Investigative Dermatology” Skin may help in getting rid of excess iron through the process of skin cell renewal.
124 citations
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October 2019 in “Frontiers in Immunology” Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.
3 citations
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January 2025 in “Journal of Natural Products” Calancardin B may help reduce inflammation in immune cells.
15 citations
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June 2021 in “International Journal of Molecular Sciences” CMC2.24 and CMC2.23 reduce melanin safely and effectively.
1 citations
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January 2005 in “Experimental Dermatology” MC-1R in skin cells may influence inflammation and collagen production.
September 2023 in “Journal of the American Academy of Dermatology” CTP-543 significantly improved eyebrow and eyelash regrowth and patient satisfaction in adults with alopecia areata.
45 citations
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January 2010 in “Journal of Veterinary Medical Science” A gene mutation causes curly hair and hair loss in rats.
3 citations
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June 2022 in “European journal of human genetics” A new type of pachyonychia congenita linked to a specific keratin gene mutation was found in two Pakistani families.
1 citations
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January 2014 Crataegus pinnatifida extract promotes hair growth in mice.
12 citations
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January 1987 in “Carcinogenesis” TCDD changes skin cell growth and keratin production in mice.
28 citations
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August 1992 in “Differentiation” A new pair of mouse keratins, 65 kD and 48 kD, are found in specific skin areas and are linked to a unique skin differentiation type.
33 citations
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March 1994 in “PubMed” High ODC and low K1 and K10 may indicate early skin tumors in mice.
December 2025 in “International Journal of Innovative Technologies in Social Science” Ritlecitinib is generally safe for long-term use, with mostly mild side effects.
October 2013 in “Journal of Investigative Dermatology” Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.