610 citations
,
April 2014 in “Nature Reviews Immunology” The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.
434 citations
,
October 2003 in “PTR. Phytotherapy research/Phytotherapy research” Natural products in cosmetics are beneficial for skin and hair care with low toxicity.
355 citations
,
August 2013 in “Acta Biomaterialia” The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.
305 citations
,
February 2007 in “Hormone and metabolic research” Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.
260 citations
,
January 2019 in “Pharmaceutics” Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.
252 citations
,
January 2008 in “Trends in Endocrinology and Metabolism” Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.
239 citations
,
December 2013 in “Scientific Reports” A new method quickly creates controllable cell clusters for tissue engineering and drug testing.
238 citations
,
March 2013 in “Development” Fat cells help recruit healing cells and build skin structure during wound healing.
233 citations
,
February 2018 in “Polymers” Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.
232 citations
,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
232 citations
,
January 2013 in “Nature Cell Biology” Understanding where cancer cells come from helps create better prevention and treatment methods.
202 citations
,
August 2007 in “Biomaterials” Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.
202 citations
,
June 2005 in “Aaps Pharmscitech” Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.
141 citations
,
August 2017 in “Developmental Dynamics” The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.
141 citations
,
March 2011 in “Journal of Dermatology” Eczema and fungal infections are the most common skin problems in Japan, with different age groups and genders affected by various conditions.
138 citations
,
May 2000 in “Maturitas” Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.
137 citations
,
October 2009 in “The American journal of pathology” Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.
137 citations
,
June 2005 in “Climacteric” Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.
131 citations
,
May 2015 in “Experimental Dermatology” Microneedles help improve skin appearance and deliver skin treatments effectively, but safety concerns need more research and regulation.
128 citations
,
March 2016 in “Advanced Pharmaceutical Bulletin” Smaller nanoparticles penetrate skin better, especially through hair follicles.
127 citations
,
June 2008 in “British Journal of Clinical Pharmacology” Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
127 citations
,
July 2002 in “EMBO journal” Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.
120 citations
,
July 2005 in “Dermatologic surgery” Niacinamide improves aging skin and is safe for use in cosmetics.
119 citations
,
October 1992 in “Fundamental & Clinical Pharmacology” Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.
117 citations
,
August 2019 in “Drug Design Development and Therapy” Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.
109 citations
,
September 2011 in “Human molecular genetics online/Human molecular genetics” New treatments targeting specific genes show promise for treating keratin disorders.
107 citations
,
August 2012 in “Seminars in Cell & Developmental Biology” The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
105 citations
,
May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” Activating TRPV3 stops human hair growth.
96 citations
,
June 2017 in “Nature Communications” A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.
94 citations
,
September 2014 in “Therapeutic Delivery” Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.