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GlossaryCollagen Type VII

protein crucial for anchoring skin layers together

Collagen Type VII is a specific type of collagen protein that plays a crucial role in anchoring the outer layer of the skin (epidermis) to the underlying layer (dermis). It forms structures known as anchoring fibrils, which are essential for maintaining skin integrity and preventing blistering. Defects in Collagen Type VII can lead to a genetic condition called dystrophic epidermolysis bullosa, characterized by fragile skin that easily blisters and tears.

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research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle.

45 citations , August 1992 in “PubMed”

The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.

research Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells

1 citations , May 2024 in “Journal of Dermatological Science”

Injecting specific cells into the skin can help improve skin structure and reduce blisters in a genetic skin disorder.

research Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway

April 2026 in “Frontiers in Cell and Developmental Biology”

Exosomes from stem cells can rejuvenate the scalp and improve hair growth.

research Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C

July 2025 in “Advanced Science”

Collagen VI and Semaphorin 3C are important for hair pigmentation and could help treat pigmentation disorders.

research
Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An in vitro and in vivo Study

34 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.

research Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified

125 citations , August 1992 in “Development”

Implanted dermal papillae can induce hair growth in rat ear wounds.

research Cytotoxicity and Collagen Expression Effects of Tideglusib Administration on Human Periodontal Cells: An In-Vitro Study

10 citations , May 2020 in “Clinical and Experimental Health Sciences”

Tideglusib may help bone regeneration without being toxic at low doses.

research Cultured dermal papilla cells of the rat vibrissa follicle. Proliferative activity, adhesion properties and reorganization of the extracellular matrix in vitro

27 citations , December 1997 in “Archives of Dermatological Research”

Rat dermal papilla cells have unique properties and interact differently with their environment compared to other skin cells.

research Melanocytes from the Outer Root Sheath of Hair Follicles Cultivated on Collagen Membrane Improve their Melanotic Properties

5 citations , January 2012 in “Journal of Tissue Science & Engineering”

Collagen membranes improve melanocyte growth for treating skin depigmentation.

research Alpaca (Vicugna pacos) Skin Analyzed Under Architecture and Structure

April 2024 in “UNESP Institutional Repository (São Paulo State University)”

Alpaca skin has glands, hair follicles, and different collagen types.

research 707 Guiding skin organoid generation via extracellular matrix cues and spatially controlled morphogen gradients

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists improved how to make skin-like structures from stem cells using special gels and a device that controls growth signals, leading to better hair and skin features.

Recombinant Humanized Collagen Combined With Nicotinamide Increases Expression of Rat Basement Membrane Proteins and Promotes Hair Growth

research Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth

June 2025 in “Frontiers in Bioengineering and Biotechnology”

Recombinant collagen with nicotinamide boosts hair growth and health.

research In vitro and ex vivo examination of topical Pomiferin treatments

10 citations , February 2014 in “Fitoterapia”

Pomiferin may improve skin and hair by increasing important protein production.

research Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects

March 2024 in “Clinical, cosmetic and investigational dermatology”

Skin Radiance Collagen improved skin and hair health in adult females.

Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo

research Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo

12 citations , September 2020 in “Stem cell research & therapy”

Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.

Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device

research Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device

March 2024 in “Advanced healthcare materials/Advanced Healthcare Materials”

Scientists developed a new way to create skin-like structures from stem cells using a special 3D gel and a device that improves cell organization and increases hair growth.

research 626 Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo

April 2021 in “Journal of Investigative Dermatology”

Early-stage skin substitutes improve wound healing and skin structure.

research Effects of extracellular matrix on the growth characteristics of human dermal papillae cellsin vitro

2 citations , July 2016 in “Clinical and Experimental Dermatology”

Some types of extracellular matrix can change how human skin cells grow but don't affect their basic functions.

research Chromolaena odorata layered-nitrile rubber polymer transdermal patch enhanced wound healing in vivo

March 2024 in “PloS one”

The Chromolaena odorata patch significantly speeds up wound healing.

research Co-delivering Retinol and Niacinamide via Liposomes: Enhanced Stability, Efficient Skin Permeation, and Improved Anti-Aging/Skin-Brightening Efficacy

August 2025

The new delivery system makes retinol and niacinamide more stable and effective for anti-aging and skin-brightening.

research Hair Follicle Units Improving the Construction of Tissue Engineered Skin in Vitro

January 2013 in “Journal of Tissue Engineering and Reconstructive Surgery”

Inserting hair follicle units improved the development of tissue-engineered skin.

Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

8 citations , April 2017 in “Journal of Dermatological Science”

Hair loss is caused by the breakdown of a protein called COL17A1 in hair follicle stem cells.

research Using proteomics to compare the molecular structures of sulfide and permeate-depilated sheepskins

January 2024 in “Collagen and leather”

The conclusion is that using bovine milk permeate to remove wool from sheepskins is eco-friendly and results in smoother, higher quality leather compared to traditional sulfide methods.

research 1327 Effect of ginsenoside Rd on dermal epidermal junction in fibroblast

April 2018 in “Journal of Investigative Dermatology”

Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.

research Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids

14 citations , May 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

research 644 Response of distinct human dermal fibroblast lineages to visible radiation: Potential for differential light-based therapy

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different types of human skin cells respond uniquely to various colors and doses of light, which could lead to specialized light treatments for skin conditions.

research Basement membrane changes in lichen planopilaris

7 citations , June 2009 in “Journal of the European Academy of Dermatology and Venereology”

Basement membrane changes in lichen planopilaris cause scarring and permanent hair loss.

research 312 CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells

1 citations , September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.