research Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)
Human skin can produce steroids from cholesterol.
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360-390 / 1000+ resultsresearch Fetal alpha 5-reductase Val89Leu mutation is associated with late miscarriage
A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.
research Impact of estrogens in males and androgens in females
Both estrogens and androgens are important for health in both males and females.
research In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond
New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.
research The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function
The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.
research The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.
research Intracrine androgen biosynthesis, metabolism and action revisited
The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
research Mineral Malnutrition Following Bariatric Surgery
Bariatric surgery can cause serious mineral deficiencies, requiring better patient education and monitoring.
research Advancements and challenges in stem cell transplantation for regenerative medicine
Stem cell transplantation shows promise for treating diseases but faces challenges like safety, ethics, and cost.
research The postnatal offspring of finasteride-treated male rats show altered ERα and PCNA expression in the liver
Finasteride use in male rats may harm their male offspring's liver function.
research Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders
New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.
research Overview of the Circadian Clock in the Hair Follicle Cycle
The circadian clock plays a key role in hair growth and its disruption can affect hair regeneration.
research Novel lysophosphoplipid receptors: their structure and function
Lysophospholipids can act as anti-inflammatory agents through specific receptors, but more research is needed.
research Role of FGFR2-signaling in the pathogenesis of acne
Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.
research The Role of Nutrition on Thyroid Function
A balanced diet with essential micronutrients is crucial for healthy thyroid function.
research Integrated Lipidomics in the Secreted Phospholipase A2 Biology
Different sPLA2 enzymes have unique roles in phospholipid metabolism and biological processes.
research SOX9 in organogenesis: shared and unique transcriptional functions
SOX9 is essential for the development of various organs and hair follicles.
research Synopsis: 2005 Annual Meeting of the American Society of Andrology
The meeting highlighted promising genetic treatments for male fertility issues but noted concerns about certain cancer risks and ICSI safety.
research Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation
Lipid peroxidation worsens skin diseases but may help treat cancer.
research Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation
Photobiomodulation is safe for skin rejuvenation, even for those with a cancer history.
research The Search for the Causes of Common Hyperandrogenism, 1965 to Circa 2015
Significant progress was made in understanding androgen excess disorders, but much is still unknown.
research The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs
We need safe, affordable drugs to fight coronaviruses effectively.
research Evolution, classification, structure, and functional diversification of steroid 5α-reductase family in eukaryotes
Steroid 5α-reductase evolved from protists and diversified in eukaryotes, with specific roles in mammals and plants.
research Addressing Androgenetic Alopecia-A Complex Disorder-with a Multilateral Treatment Strategy
Treating hair loss effectively may require a multi-sided approach, using different treatments together, and topical treatments could be more effective and safer than oral ones.
research Non‐biologic immunosuppressive drugs for inflammatory and autoimmune skin diseases
Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.
research Testosterone: The Male Sex Hormone
More research is needed to understand how testosterone is maintained in adult males.
research SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism
Spironolactone may help reduce COVID-19 severity in men by blocking harmful effects of certain hormones.
research Herbal preparations for the treatment of hair loss
research Female pattern alopecia: current perspectives
Female pattern hair loss is caused by multiple factors and while treatments like topical minoxidil, hormone therapy, and low-level light therapy can help, none can fully cure it.
research FOXP3 + regulatory T cells and age‐related diseases
Targeting regulatory T cells may help treat age-related diseases.