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GlossaryCYP3A4

enzyme that metabolizes drugs and toxins in liver

CYP3A4 is an enzyme found in the liver and intestines that plays a crucial role in metabolizing many drugs and toxins in the body. It helps break down substances so they can be more easily eliminated, and its activity can affect how well medications work and their potential side effects.

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research Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model

1 citations , August 2020

Croton membranaceus root extract can change how drugs are processed in the body.

research SAT340 Matters Of The HAART - Ritonavir Induced CYP3A4 Inhibition of Intranasal Fluticasone Leading To Cushing’s Syndrome

1 citations , October 2023 in “Journal of the Endocrine Society”

HIV medication ritonavir can increase the effects of nasal sprays like fluticasone, causing Cushing's syndrome.

A Simple Decision Tree for Identifying Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

research A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

November 2020 in “Journal of Pharmaceutical Sciences”

The decision tree can predict drug absorption issues with good accuracy but needs more validation and adjustments for other factors.

research CYP3A5 Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP

March 2025 in “OncoTargets and Therapy”

A specific genetic trait in tumor cells is linked to longer survival without disease in certain lymphoma patients.

research A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function

October 2023 in “Journal of pharmaceutical investigation”

Finasteride dosages should be adjusted based on CYP3A5 genotype and liver function to avoid side effects.

research Pilot study: genetic distribution of AR, FGF5, SULT1A1 and CYP3A5 polymorphisms in male Mexican population with androgenetic alopecia.

January 2022 in “PubMed”

Certain genetic variations are linked to hair loss in Mexican men.

Cloning of a Functional Vitamin D Receptor from the Lamprey, an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

104 citations , May 2003 in “Endocrinology”

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

research Relationship of Early-Onset Baldness to Prostate Cancer in African-American Men

21 citations , March 2013 in “Cancer Epidemiology, Biomarkers & Prevention”

Early-onset baldness is linked to a higher risk of aggressive prostate cancer in African-American men, especially before age 60.

research Drug safety evaluation of exemestane

7 citations , March 2011 in “Expert Opinion on Drug Safety”

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

Drug Interactions Between Common Dermatological Medications and the Oral Anti-Covid-19 Agents Nirmatrelvir-Ritonavir and Molnupiravir

research Drug interactions between common dermatological medications and the oral anti-COVID-19 agents nirmatrelvir-ritonavir and molnupiravir

5 citations , December 2022 in “Annals Academy of Medicine Singapore”

Some skin medications can have harmful interactions with the COVID-19 drug nirmatrelvir-ritonavir, but not with molnupiravir.

Single Nucleotide Polymorphisms Associated with Elevated Alanine Aminotransferase in Patients Receiving Asunaprevir Plus Daclatasvir Combination Therapy for Chronic Hepatitis C

research Single nucleotide polymorphisms associated with elevated alanine aminotransferase in patients receiving asunaprevir plus daclatasvir combination therapy for chronic hepatitis C

2 citations , July 2019 in “PLOS ONE”

Certain genetic variations are linked to higher liver enzyme levels in patients treated for chronic hepatitis C with specific drugs.

research High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

2 citations , December 2013 in “Xenobiotica”

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

research Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency Due to an Interaction Between Fluticasone and Ritonavir

1 citations , May 2021 in “Journal of the Endocrine Society”

A woman developed Cushing syndrome and adrenal insufficiency from using fluticasone and ritonavir together.

research In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites

1 citations , January 2010

Finasteride is mainly broken down by the enzyme CYP3A4, affecting its levels in the body.

research Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing

November 2025 in “Drug Testing and Analysis”

Epristeride's metabolism involves key metabolites and proteins, affecting its use in doping tests.

research Arecaceae

October 2015 in “Elsevier eBooks”

Chewing betel nut may increase the risk of type 2 diabetes, and saw palmetto can improve urinary symptoms in BPH with fewer side effects but may cause bleeding and allergic reactions.

Ferrous Sulfate Overdose: Interaction Between Finasteride and Hypericum

research Ferrous sulfate overdose

January 2011 in “Reactions Weekly”

St. John's Wort may reduce the effectiveness of finasteride by increasing its breakdown in the body.

research Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient

37 citations , September 2002 in “Acta pædiatrica”

A cystic fibrosis patient developed Cushing's syndrome from a drug interaction between itraconazole and budesonide, which improved after stopping the medications.

research Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient

6 citations , September 2002 in “Acta pædiatrica”

A cystic fibrosis patient developed Cushing's syndrome from a drug interaction between itraconazole and inhaled budesonide.

research Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm

4 citations , October 2018 in “Asia-Pacific Journal of Clinical Oncology”

CDK4/6 inhibitors have improved treatment outcomes for certain advanced breast cancer patients.

research Simvastatin-induced myoglobinuric acute kidney injury following ciclosporin treatment for alopecia universalis

January 2012 in “The Year book of dermatology”

A woman developed severe kidney injury from using simvastatin with ciclosporin, highlighting the need for careful monitoring when combining these drugs.

research Effects of mitotane treatment on human steroid metabolism: implications for patient management

26 citations , July 2012 in “Endocrine Connections”

Mitotane changes steroid breakdown, affecting cortisol availability.

research Docking-based workflow and ADME prediction of some compounds in Curcuma longa and Andrographis paniculata as polymerase PA-PB1 inhibitors of influenza A/H5N1 virus

8 citations , January 2023 in “Journal of Research in Pharmacy”

Compounds from turmeric and bitter show strong potential as antiviral agents against the influenza A virus.

Self-Microemulsifying Systems of Finasteride with Enhanced Oral Bioavailability: Multivariate Statistical Evaluation, Characterization, Spray-Drying and In Vivo Studies in Human Volunteers

research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers

39 citations , November 2015 in “Nanomedicine”

Improved Finasteride delivery for hair loss treatment.

The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

research The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

33 citations , November 2008 in “European Journal of Pharmaceutical Sciences”

St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.

research Hair Loss Induced by Lopinavir-Ritonavir

7 citations , July 2007 in “Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy”

The medication lopinavir-ritonavir may cause severe hair loss.

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Related Terms

Research

research Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model

research SAT340 Matters Of The HAART - Ritonavir Induced CYP3A4 Inhibition of Intranasal Fluticasone Leading To Cushing’s Syndrome

research A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

research CYP3A5 Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP

research A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function

research Pilot study: genetic distribution of AR, FGF5, SULT1A1 and CYP3A5 polymorphisms in male Mexican population with androgenetic alopecia.

research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth

research Relationship of Early-Onset Baldness to Prostate Cancer in African-American Men

research Drug safety evaluation of exemestane

research Drug interactions between common dermatological medications and the oral anti-COVID-19 agents nirmatrelvir-ritonavir and molnupiravir

research Single nucleotide polymorphisms associated with elevated alanine aminotransferase in patients receiving asunaprevir plus daclatasvir combination therapy for chronic hepatitis C

research High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

research Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency Due to an Interaction Between Fluticasone and Ritonavir

research In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites

research Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing

research Arecaceae

research Ferrous sulfate overdose

research Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient

research Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient

research Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm

research Simvastatin-induced myoglobinuric acute kidney injury following ciclosporin treatment for alopecia universalis

research Effects of mitotane treatment on human steroid metabolism: implications for patient management

research Docking-based workflow and ADME prediction of some compounds in Curcuma longa and Andrographis paniculata as polymerase PA-PB1 inhibitors of influenza A/H5N1 virus

research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers

research The effect of St. John’s wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men

research Hair Loss Induced by Lopinavir-Ritonavir

research Treatment of Delusional Infestation with Olanzapine

research ラット精巣におけるビタミンD 代謝関連遺伝子の発現解析

research Topical dutasteride with microneedling in treatment of male androgenetic alopecia

research Cytochrome P450: A Target for Drug Development for Skin Diseases