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Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

research Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons

10 citations , December 2017 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

research Protein-phosphatase inhibitors block root hair growth and alter cortical cell shape of Arabidopsis roots

61 citations , December 1994 in “Planta”

research Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice

16 citations , October 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

Dutasteride may protect the brain in early Parkinson's disease.

An Innovative Phase 1b Trial Demonstrating Proof-of-Pharmacology for Two Novel IRAK4-Inhibitors Using a Local and Systemic Driven Immune Response

research 1112 An innovative phase 1b trial demonstrating proof-of-pharmacology for two novel IRAK4-inhibitors using a local (Imiquimod) and systemic (LPS) driven immune response

April 2023 in “Journal of Investigative Dermatology”

Two new IRAK4-inhibitors effectively reduced skin inflammation and immune response markers in healthy volunteers.

research Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo

February 2026 in “International Journal of Molecular Sciences”

Silencing SFRP1 alone promotes hair growth, but adding DKK1 does not help.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research Biochemical features of primary cells from a pediatric patient with a gain-of-function ODC1 genetic mutation

15 citations , June 2019 in “Biochemical Journal”

A new genetic disorder caused by an ODC1 mutation can be treated with DFMO.

research Impairment of Hair-Inducing Capacity of Three-Dimensionally Cultured Human Dermal Papilla Cells by the Ablation of STAT5

1 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

STAT5 is crucial for hair growth in 3D cultured human dermal papilla cells.

Isoallopregnanolone Reduces Tic-Like Behaviors in the D1CT-7 Mouse Model of Tourette Syndrome

research Isoallopregnanolone reduces tic‐like behaviours in the D1 CT ‐7 mouse model of Tourette syndrome

15 citations , June 2019 in “Journal of Neuroendocrinology”

Isoallopregnanolone may be a safe and effective treatment for reducing tics in a mouse model of Tourette syndrome.

research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

26 citations , December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

research Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development

14 citations , May 2016 in “International Journal of Molecular Sciences”

PP2Acα is essential for proper hair and skin development.

Effects of Combined Therapy of D-004 and Finasteride on Testosterone-Induced Prostate Hyperplasia in Rats

research Efectos de la terapia combinada del D-004 y el Finasteride sobre la hiperplasia de próstata inducida por testosterona en ratas

January 2007 in “El Servicio de Difusión de la Creación Intelectual (National University of La Plata)”

Combining D-004 and finasteride is more effective at reducing prostate enlargement than using either alone.

research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity

13 citations , October 2017 in “Bioorganic & Medicinal Chemistry”

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

5-Bromo-3,4-Dihydroxybenzaldehyde Promotes Hair Growth Through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

research 5-Bromo-3,4-dihydroxybenzaldehyde Promotes Hair Growth through Activation of Wnt/β-Catenin and Autophagy Pathways and Inhibition of TGF-β Pathways in Dermal Papilla Cells

7 citations , March 2022 in “Molecules”

5-Bromo-3,4-dihydroxybenzaldehyde could potentially help hair growth by activating certain cell pathways and inhibiting others.

research The Intervention Effect of Externally Applying or Orally Administering Bifidobacterium animalis Subsp. lactis J12 on Atopic Dermatitis Induced by 2,4-Dinitrofluorobenzene

January 2026 in “Microorganisms”

Bifidobacterium animalis subsp. lactis J12 helps reduce atopic dermatitis symptoms.

research Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

2 citations , July 2017 in “Oncology Letters”

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

research A Neutralizing Prolactin Receptor Antibody Whose In Vivo Application Mimics the Phenotype of Female Prolactin Receptor-Deficient Mice

14 citations , August 2015 in “Endocrinology”

The antibody 005-C04 blocks prolactin receptors, causing reversible infertility, impaired lactation, and hair regrowth in female mice.

research The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway

January 2024 in “Cells”

Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.

research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt^WT mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study

58 citations , May 2004 in “British Journal of Dermatology”

Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.

research Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.

90 citations , January 1989 in “PubMed”

research Use of diphenylcyclopropenone for alopecia areata treatment during pregnancy

3 citations , April 2024 in “JAAD Case Reports”

DPCP may be safe for treating alopecia during pregnancy, but more research is needed.

research Direct hair growth promoting effects of mycophenolic acid

March 2014 in “Journal of The American Academy of Dermatology”

Mycophenolic acid may help hair grow by activating pathways important for hair growth.

research Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation

January 2012

Mdm2 is crucial for controlling p53 to maintain healthy cells and prevent tumors.

research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation

60 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Applying a specific inhibitor lightens skin and hair color.

research Effect of a novel steroid (PM-9) on the inhibition of 5α-reductase present in Penicillium crustosum broths

22 citations , March 2003 in “Steroids”

PM-9 and finasteride effectively inhibit the enzyme that converts testosterone to DHT.

research 4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice

11 citations , October 2024 in “Cell Death Discovery”

4-aminopyridine helps heal burn wounds faster by reducing inflammation and promoting new blood vessel growth.

research PAK4 signaling in health and disease: defining the PAK4–CREB axis

81 citations , February 2019 in “Experimental & Molecular Medicine”

PAK4 is crucial in cancer progression, brain development, and could be a therapeutic target, especially through the PAK4-CREB axis.

research Vitiligo after Diphencyprone for Alopecia Areata

18 citations , January 2010 in “Dermatology Research and Practice”

DPCP treatment for alopecia areata can sometimes cause vitiligo.

research Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation

March 2026 in “Preprints.org”

Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.

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