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Did you mean Epithelial-Mesenchymal Transition?

GlossaryEpithelial-Mesenchymal Transition

cells change from stationary epithelial to mobile mesenchymal

Epithelial-Mesenchymal Transition (EMT) is a biological process where epithelial cells, which are usually stationary and form tight layers, transform into mesenchymal cells, which are more mobile and can migrate. This process is crucial in various physiological contexts, such as wound healing and embryonic development, but it also plays a role in pathological conditions like cancer metastasis and fibrosis.

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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations , November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research Epithelial‐to‐mesenchymal transition in cutaneous wound healing: Where we are and where we are heading

141 citations , August 2017 in “Developmental Dynamics”

The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.

research Epithelial-to-Mesenchymal Stem Cell Transition in a Human Organ: Lessons from Lichen Planopilaris

71 citations , October 2017 in “Journal of Investigative Dermatology”

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

research Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing

31 citations , December 2022 in “Cold Spring Harbor Perspectives in Biology”

Understanding cell transitions can lead to better wound healing treatments.

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

research WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis

56 citations , January 2022 in “Burns & Trauma”

WNT5A contributes to keloid scars by promoting cell changes through specific signaling pathways.

research Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes

46 citations , July 2015 in “Wound repair and regeneration”

Keloid scars may form due to changes in skin cell characteristics and specific protein signaling.

research Expression of Snail1 in the fibrotic dermis of postmenopausal frontal fibrosing alopecia: possible involvement of an epithelial-mesenchymal transition and a review of the Japanese patients

29 citations , February 2010 in “British Journal of Dermatology”

Snail1 may contribute to fibrosis in frontal fibrosing alopecia in postmenopausal women.

research Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition

19 citations , September 2021 in “British journal of dermatology/British journal of dermatology, Supplement”

Activating PPAR-γ signalling can protect hair follicle stem cells from damage caused by chemotherapy.

research Drugs targeting epithelial–mesenchymal transition molecules for treatment of lichen planopilaris

3 citations , May 2022 in “Clinical and experimental dermatology”

Drugs targeting EMT molecules show promise for treating lichen planopilaris.

Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

research Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

May 2023 in “Journal of Endocrinology and Reproduction”

Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.

research Epithelial Mesenchymal Transition and Tissue Healing

August 2019 in “Journal of Medical Histology”

EMT helps heal tissues but can cause scarring and other issues if prolonged.

research 269 The PPAR-γ modulator, N-acetyl-GED, protects from epithelial-mesenchymal-transition to human hair follicles: Potential relevance for scarring alopecia

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

N-acetyl-GED may help prevent and partially reverse a process that leads to scarring hair loss.

research Epithelial elements in superficial angiomyxomas: mimicry of adnexal development, and mesenchymal‐to‐epithelial transition

June 2025 in “Histopathology”

Epithelial elements in superficial angiomyxomas are non-neoplastic growths mimicking embryogenesis.

Human Dermal Fibroblasts and Mast Cell Populations Are Altered in Hidradenitis Suppurativa, With Epithelial-Mesenchymal-Transition Signals Ameliorated by Spleen Tyrosine Kinase Antagonism

research 1323 Human dermal fibroblasts and mast cell populations are altered in hidradenitis suppurativa, with epithelial-mesenchymal-transition signals ameliorated by spleen tyrosine kinase antagonism.

April 2023 in “Journal of Investigative Dermatology”

Skin cells and immune cells change in a skin condition called hidradenitis suppurativa, and a certain treatment can improve these changes.

research hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

3 citations , December 2023 in “Aging”

hsa_circ_0002980 can help stop liver cancer cells from growing and spreading.

research Equine Hoof Stratum Internum K14+CD105+ Progenitor Cells: Culture, Characterization, and Model of Epithelial to Mesenchymal Transition

October 2019

Equine hoof progenitor cells can help develop therapies for hoof diseases like laminitis.

research An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation

30 citations , November 2018 in “EMBO Reports”

The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.

research 1458 EMT-inhibiting transcription factor Ovol2 regulates directional cell migration and proliferation in adult skin epithelia

April 2018 in “Journal of Investigative Dermatology”

Ovol2 is important for proper skin healing and hair growth.

research LB999 Role of transcription factor Ovol2 in skin epithelial regeneration and repair

September 2017 in “Journal of Investigative Dermatology”

Ovol2 is essential for normal skin and hair regeneration.

research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

80 citations , April 2018 in “Trends in Molecular Medicine”

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression?

research 382 Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge?

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Linalool in personal care products may contribute to hair loss by damaging hair follicle stem cells and triggering harmful immune responses.

research ESDR382 - Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge?

September 2022

Linalool in personal care products may worsen frontal fibrosing alopecia by damaging hair follicle stem cells and triggering harmful immune responses.

research Zwischen Tradition und Innovation Historische Plätze in der Bundesrepublik Deutschland nach 1945

1 citations , January 2004

Understanding hair growth phases and signals can help treat hair disorders.

research Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture

2 citations , February 2024 in “Nature cell biology”

Mechanical forces are crucial for shaping cells and forming tissues during development.

research Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment

38 citations , January 2019 in “International Journal of Women's Dermatology”

The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.

research Hair curvature: a natural dialectic and review

28 citations , March 2014 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society”

The document concludes that hair curvature can be explained by the growth patterns caused by the shape and separation of cells in the hair follicle and is affected by specific molecular pathways.

research P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression

24 citations , December 2016 in “Stem Cell Research & Therapy”

P311 helps skin stem cells become myofibroblast-like cells, aiding wound healing.

RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development

research RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development

5 citations , July 2022 in “Orphanet journal of rare diseases”

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

research 0977 Pathogenic hallmarks of primary lymphocyte-mediated scarring alopecia revealed by single nuclear and spatial multiomics

July 2025 in “Journal of Investigative Dermatology”

Scarring alopecia involves increased immune cells and specific gene changes near damaged hair follicles.