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GlossaryERK Pathway

chain of proteins transmitting signals from cell surface to DNA

The ERK Pathway, also known as the Extracellular Signal-Regulated Kinase Pathway, is a chain of proteins in the cell that communicates signals from a receptor on the cell's surface to the DNA in the nucleus. This pathway plays a crucial role in regulating various cellular activities, including growth, division, and differentiation. It is particularly important in the context of hair biology, as disruptions in this pathway can influence hair growth and contribute to conditions like alopecia.

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research Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

10 citations , December 2018 in “Medical Science Monitor”

The MAPK/ERK pathway is crucial in controlling cell growth and death in finasteride-induced hypospadias.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations , September 2020 in “Molecules”

Quercitrin may help treat hair loss by promoting hair growth and improving cell health.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations , March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

Hair Growth-Promotion Effects of Different Alternating Current Parameter Settings Are Mediated by the Activation of Wnt/β-Catenin and MAPK Pathway

research Hair growth‐promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/β‐catenin and MAPK pathway

27 citations , August 2015 in “Experimental Dermatology”

Certain electric currents can promote hair growth by activating specific cell pathways.

research Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential

September 2025 in “Current Issues in Molecular Biology”

IGF-1 can help regrow hair and may be a promising treatment for hair loss.

research Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways

3 citations , September 2024 in “International Journal of Molecular Sciences”

Mathematical modeling helps understand and predict the MAPK cell signaling pathway.

research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations , March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

Epimedium Brevicornum Maxim Extract Enhances Melanin Biosynthesis and Melanosome Biogenesis/Transfer

research Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer

6 citations , September 2022 in “Frontiers in pharmacology”

Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.

research Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin

37 citations , March 2006 in “Regulatory Peptides”

Mice skin has components that could help with hair growth and might be used for diabetes treatment.

research 691 Topical curcumin promotes induction of the murine hair cycle

3 citations , April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Curcumin applied to the skin can start hair growth in mice.

research Bio-Nanovesicle-Based Approaches for Hair and Skin Regeneration: An Updated Concise Review

March 2026 in “Cells”

Bio-nanovesicles could improve hair and skin regeneration by delivering important molecules to repair and heal.

research Identificación de la variación molecular y genética subyacente a las enfermedades de la piel

January 2025 in “Repository of Digital Objects for Teaching Research and Culture (University of Valencia)”

Non-coding RNAs may be key in diagnosing and treating rare skin disorders.

research Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage by Centipeda minima and Brevilin A in Human Dermal Fibroblasts

1 citations , May 2025 in “Current Issues in Molecular Biology”

Centipeda minima and brevilin A protect skin cells from damage and aging.

research The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin

14 citations , July 2015 in “International Journal of Molecular Sciences”

S-Methylmethionine sulfonium can protect skin from UVB damage.

research Recombinant Filaggrin-2 microneedles reverse androgenetic alopecia by rescuing mitochondrial dysfunction in dermal papilla cells

March 2026 in “International Journal of Biological Macromolecules”

Recombinant Filaggrin-2 microneedles effectively promote hair growth and repair in hair loss.

research Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia

November 2025 in “Journal of Nanobiotechnology”

A new treatment using special nanovesicles with linoleic acid shows promise in improving hair growth and reducing irritation for hair loss.

research Epimorphin and Epithelial Morphogenesis

January 2007

Epimorphin helps shape and develop epithelial cells, like those in hair follicles.

research Chemical Constituents from Osmanthus fragrans var. aurantiacus Makino with Their In Vitro and In Silico Studies Target Anti-Inflammation by Suppressing ERK 1/2 MAPK Signaling

August 2025 in “International Journal of Molecular Sciences”

Osmanthus fragrans var. aurantiacus Makino may help treat inflammation due to its antioxidative and anti-inflammatory properties.

research Large extracellular vesicles from induced pluripotent stem cell-marrow stem cells enhance limb angiogenesis via ERK/MAPK

1 citations , July 2024 in “Nanomedicine”

Stem cell-derived vesicles improve blood vessel growth in limbs.

research The potential application of natural products in cutaneous wound healing: A review of preclinical evidence

45 citations , July 2022 in “Frontiers in Pharmacology”

Natural products can help heal wounds by affecting key biological pathways.

Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

research Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons

10 citations , December 2017 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

research Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

3 citations , January 2024 in “Cell Transplantation”

Combining platelet concentrates with stem cells improves regenerative therapies.

research Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways

27 citations , April 2021 in “Phytotherapy Research”

Curcumin may be an effective and safer anticancer agent by regulating key cell pathways.

research Betulinic acid exerts anti‐hepatitis C virus activity via the suppression of NF‐κB‐ and MAPK‐ERK1/2‐mediated COX‐2 expression

44 citations , June 2015 in “British Journal of Pharmacology”

Betulinic acid can help treat hepatitis C by stopping virus replication.

research The Role of LncRNAs in Radio- and Chemoresistance of Glioblastoma: Prognostic or Therapeutic?

September 2025 in “Current Oncology”

LncRNAs may help improve brain cancer treatment and diagnosis.

research Biological therapy in the treatment of melanoma

3 citations , October 2018 in “Journal of Mind and Medical Sciences”

Biological therapy boosts the immune system to effectively fight melanoma.

Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells

research Wnt/β‐catenin and ERK pathway activation: A possible mechanism of photobiomodulation therapy with light‐emitting diodes that regulate the proliferation of human outer root sheath cells

43 citations , September 2017 in “Lasers in Surgery and Medicine”

LED light therapy may help hair growth by activating certain cell pathways.

research Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK—ERK Signaling Pathway

45 citations , April 2013 in “Cell Transplantation”

Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.

research VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway

23 citations , June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

Lactoferrin Promotes Hair Growth in Mice and Increases Dermal Papilla Cell Proliferation Through Erk/Akt and Wnt Signaling Pathways

research Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways

18 citations , April 2019 in “Archives of Dermatological Research”

Lactoferrin helps mice grow hair by increasing cell growth and hair follicle development.