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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP) has potential in enhancing tissue regeneration and improving hair conditions, but its effectiveness varies due to individual differences.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

Exosome therapy could be a promising new way to treat hair loss.

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

Inflammation and immunity play a key role in androgenetic alopecia, with better treatment outcomes in certain immune-positive cases.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

Oral contraceptives help treat acne and hair issues by balancing hormones but need careful use due to possible side effects.

Hormones affect prostate health and disease, with certain hormone imbalances linked to prostate cancer and benign prostatic hyperplasia.

Cross-sex hormone treatment in transsexual individuals helps understand how sex hormones affect diseases like heart disease and diabetes.

Reduced sexual drive may be linked to male breast cancer, while anti-estrogenic factors might lower the risk.

Females have higher estrogen receptor levels in hair than males, and these levels decrease in white hair compared to black hair.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.

The effects of estrogen on human scalp hair growth are unclear and need more research.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Certain gene variants in estrogen receptors are linked to polycystic ovary syndrome, mainly affecting metabolism, in Tunisian women.

Certain gene patterns in breast cancer are linked to how active hormone receptors are and could affect patient survival.

Future hormone therapy trials should match the diverse needs and priorities of the gender-diverse community.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Neurosteroids like neuro-estrogen and neuro-androgen are crucial for brain function and can improve cognition and protect against aging-related decline.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Activating β-catenin in certain skin cells speeds up hair growth in mice.

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Estrogen and progesterone don't directly affect hair growth in androgenic alopecia and alopecia areata.

Humans can accurately guess age from faces, with women being slightly better at it, and age perception is linked to evolutionary factors.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Aging scalp skin contributes to hair aging and loss, and more research is needed to develop better hair loss treatments.