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GlossaryExtracellular Matrix Organization

network of proteins and molecules outside cells is structured

Extracellular Matrix Organization (ECM Organization) refers to the process by which the network of proteins and other molecules outside cells is structured and maintained. This matrix provides structural support to tissues, influences cell behavior, and plays a crucial role in wound healing, tissue repair, and overall cellular function. Proper ECM organization is essential for maintaining healthy skin and hair, and disruptions in this process can contribute to conditions like alopecia.

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research Cultured dermal papilla cells of the rat vibrissa follicle. Proliferative activity, adhesion properties and reorganization of the extracellular matrix in vitro

27 citations , December 1997 in “Archives of Dermatological Research”

Rat dermal papilla cells have unique properties and interact differently with their environment compared to other skin cells.

research Cross-species comparative spatial transcriptomics of hair follicle-T cell interactions identifies conserved drivers of cutaneous lupus erythematosus skin disease and associated hair loss

July 2026 in “Nature Communications”

CXCR3+ T cells and B cells drive skin disease and hair loss in lupus, with potential targets identified for treatment.

research Dynamic interactions of lymphatic vessels at the hair follicle stem cell niche during hair regeneration

1 citations , February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

Lymphatic vessels are essential for hair follicle regeneration and growth.

research SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

87 citations , September 2019 in “Nature Communications”

SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.

research Endothelin-1 combined with extracellular matrix proteins promotes the adhesion and chemotaxis of amelanotic melanocytes from human hair follicles in vitro

11 citations , August 2006 in “Cell Biology International”

Endothelin-1 helps amelanotic melanocytes stick and move better on certain proteins.

The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility

44 citations , June 2009 in “Biomaterials”

Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.

Latent Transforming Growth Factor Beta-Binding Protein 1 (LTBP1): Roles as a Multifunctional Extracellular Matrix Regulator in Human Disease. From Molecular Mechanisms to Clinical Translation Prospects

research Latent transforming growth factor beta-binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease. From molecular mechanisms to clinical translation prospects

March 2026 in “Folia Histochemica et Cytobiologica”

LTBP1 is a key regulator in diseases and a potential target for new treatments.

Investigating the Role of Various Extracellular Matrix in Androgenetic Alopecia: Insights from Immunostaining and Quantitative Analysis - A Pilot Study

research Investigating the role of various extracellular matrix in androgenetic alopecia: Insights from immunostaining and quantitative analysis – A pilot study

October 2024 in “Dermatologica Sinica”

ECM changes may play a role in hair loss, with differences between males and females.

research Current application of tissue-engineered dermal scaffolds mimicking the extracellular matrix microenvironment in wound healing

11 citations , January 2025 in “Regenerative Therapy”

Tissue-engineered scaffolds help heal difficult wounds by supporting cell growth and repair.

Wound Healing in Development: Mechanisms and Regulation

research Wound healing in development

29 citations , September 2012 in “Birth Defects Research”

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

research Hair Regeneration under Stress

2 citations , May 2018 in “Journal of Investigative Dermatology”

Mice can regrow hair on wounds due to specific cell interactions and mechanical forces not seen in rats.

research A Human Folliculoid Microsphere Assay for Exploring Epithelial– Mesenchymal Interactions in the Human Hair Follicle

71 citations , October 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

HFMs can help study hair growth and test potential hair growth drugs.

research Mechanical forces in skin disorders

65 citations , March 2018 in “Journal of Dermatological Science”

Skin problems can be caused or worsened by physical forces and pressure on the skin.

research Biologically Driven Innovations in Aesthetic Surgery: Advances in Regenerative and Cellular Therapies

November 2025 in “IECCMEXICO”

Regenerative therapies are improving aesthetic surgery by enhancing tissue quality and healing.

research Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

363 citations , March 2017 in “Nature Communications”

Stem cells help heal wounds by rapidly dividing and migrating to the wound edge.

research Calreticulin: non‐endoplasmic reticulum functions in physiology and disease

341 citations , November 2009 in “The FASEB Journal”

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

research Stem cell dynamics in the hair follicle niche

135 citations , December 2013 in “Seminars in Cell & Developmental Biology”

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

research The blastema and epimorphic regeneration in mammals

85 citations , December 2017 in “Developmental Biology”

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

research Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production

21 citations , March 2025 in “Journal of Extracellular Vesicles”

Hydrogels can enhance stem cell activity, but more research is needed to optimize their use.

In Vitro Biomimetic Platforms Featuring a Perfusion System and 3D Spheroid Culture Promote the Construction of Tissue-Engineered Corneal Endothelial Layers

research In vitro biomimetic platforms featuring a perfusion system and 3D spheroid culture promote the construction of tissue-engineered corneal endothelial layers

14 citations , April 2017 in “Scientific Reports”

Using a perfusion system and 3D spheroid culture improves the growth of corneal cell layers for tissue engineering.

research The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

11 citations , February 2022 in “Scientific Reports”

CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.

Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways

research Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways

5 citations , October 2025 in “International Journal of Nanomedicine”

Traditional Chinese Medicine and biomaterials help heal chronic wounds by targeting multiple pathways.

Detecting the Mechanism Behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus Nippon) Dermal Papilla Cells to Three-Dimensional Pattern

research Detecting the Mechanism behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus nippon) Dermal Papilla Cells to Three-Dimensional Pattern

2 citations , April 2021 in “International Journal of Molecular Sciences”

The study concluded that changing the culture conditions can cause sika deer skin cells to switch from a flat to a 3D pattern, which is important for creating hair follicles.

research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.

Advances in Tissue Bioengineering and Regenerative Aesthetic Medicine: Emerging Strategies for Tissue Restoration, Functional Recovery, and Personalized Healthcare

research Advances in Tissue Bioengineering and Regenerative Aesthetic Medicine: Emerging Strategies for Tissue Restoration, Functional Recovery, and Personalized Healthcare

June 2026 in “International Science Journal”

Tissue bioengineering and regenerative medicine are improving tissue restoration and recovery, with promising new therapies and personalized approaches.

Progress and Perspectives on Hydrogel-Assisted Skin Organoids

research Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

Different types of sun exposure damage skin cells and immune cells, with chronic exposure leading to more severe and lasting damage.