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The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

research The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia

49 citations , August 2003 in “Journal of The American Academy of Dermatology”

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

research Author response: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

1 citations , July 2018

Fgf20 helps form hair follicle structures by stopping cell division and increasing cell movement.

research Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling*

25 citations , August 2010 in “Journal of Biological Chemistry”

Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.

research Activation of EGF and FGF signaling in developing mouse skin inhibits hair follicle morphogenesis

January 2007

EGF and FGF signaling stops hair follicle development in mice.

research Insulin-like growth factor 1 and hair growth

98 citations , November 1999 in “Dermatology Online Journal”

IGF-1 can boost hair growth by promoting cell growth and preventing cell death.

research Safety and efficacy analysis of liposomal insulin-like growth factor-1 in a fluid gel formulation for hair-loss treatment in a hamster model

18 citations , August 2012 in “Clinical and Experimental Dermatology”

Liposomal IGF-1 safely and effectively treats hair loss in hamsters.

research Decision letter: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

April 2018

Fgf20 is crucial for hair follicle formation by influencing cell movement and growth.

research Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats

75 citations , September 2007 in “Journal of Heredity”

FGF5 gene mutations cause long hair in domestic cats.

research The Historical Studies Underpinning the Concept of Hair Follicle Neogenesis

January 2022 in “Springer eBooks”

Fibroblast growth factors are crucial for hair follicle development and regeneration.

Prostaglandin F2α Stimulates Growth of Human Intermediate Hair Follicles in Ex Vivo Organ Culture with Potential Clinical Relevance

research Prostaglandin F2α stimulates the growth of human intermediate hair follicles in ex vivo organ culture with potential clinical relevance

June 2025 in “Frontiers in Physiology”

Prostaglandin F2α may help treat hair loss by promoting hair growth.

The Activin Binding Proteins Follistatin and Follistatin-Related Protein Are Differentially Regulated In Vitro and During Cutaneous Wound Repair

research The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair

46 citations , December 2001 in “Journal of Endocrinology/Journal of endocrinology”

FLRG and follistatin have different roles in wound healing.

research Potential roles of FGF5 as a candidate therapeutic target in prostate cancer.

2 citations , January 2023 in “PubMed”

Targeting FGF5 could help treat prostate cancer.

research A temperature-sensitive FERONIA mutant allele that alters root hair growth

37 citations , December 2020 in “PLANT PHYSIOLOGY”

A mutant FERONIA gene affects root hair growth at high temperatures.

research FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures

1 citations , July 2025 in “Frontiers in Genetics”

FilaggrinHigh melanomas have active FGFR signaling and weak GNA14 and Th1 signatures.

research Efficacy and Safety of Rb‐bFGF in Hair Transplantation: A Prospective and Comparative Study

September 2025 in “Journal of Cosmetic Dermatology”

Rb-bFGF improves hair transplant results and patient satisfaction with fewer complications.

research Reawakening GDNF's regenerative past in mice and humans

1 citations , April 2022 in “Regenerative Therapy”

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

research Severe scarring alopecia associated with combinational use of ficlatuzumab and gefitinib: a clinical and immunohistochemistry study

1 citations , December 2012 in “Journal of dermatological science”

Combining ficlatuzumab and gefitinib can cause severe scarring hair loss.

Free Androgen Index: Marker of Premature Androgenetic Alopecia in Men

research Free Androgen Index (FAI): Marker of Premature Androgenetic Alopecia in Men

1 citations , January 2016 in “Journal of Microbial & Biochemical Technology”

The Free Androgen Index (FAI) is the best indicator of early hair loss in men before age 30.

research Exogenous IGF-1 promotes hair growth by stimulating cell proliferation and down regulating TGF-β1 in C57BL/6 mice in vivo

53 citations , March 2014 in “Growth Hormone & IGF Research”

IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.

research An epidermis‐permeable dipeptide is a potential cosmetic ingredient with partial agonist/antagonist activity toward fibroblast growth factor receptors

3 citations , May 2019 in “Journal of Cosmetic Dermatology”

Pro-Ile could be used in cosmetics to improve skin, hair growth, and healing.

research Gefitinib-induced hair alterations: Figure 1

7 citations , January 2009 in “BMJ Case Reports”

Gefitinib can cause slower, finer, brittle, and curly scalp hair.

research Severe Refractory Scarring Alopecia Associated With Combinational Use of Ficlatuzumab (AV-299) and Gefitinib

6 citations , May 2013 in “Journal of Clinical Oncology”

Combining Ficlatuzumab and Gefitinib can cause severe hair loss.

research Review of Women with Vision: The Presentation Sisters of South Dakota, 1880-1985

January 1990

Knocking out the FGF5 gene in sheep increased wool production and hair-follicle density.

research EXPRESSION CHARACTERISTICS OF bFGF, EGF, TGF-β ISOFORMS AND THEIR RECEPTORS IN SKIN FROM FETUS AND ADULT

January 2003 in “Jiefangjun yixue zazhi”

Growth factors in skin increase with age, aiding development and healing.

research The Dark Side of Gefitinib: Reflectance Confocal Microscopy Applied to Hair Hyperpigmentation

4 citations , October 2019 in “Skin Appendage Disorders”

Gefitinib can cause hair and eyebrow darkening.

research Pharmacological Application of Growth Factors: Basic and Clinical

2 citations , January 2015 in “BioMed Research International”

Growth factor treatments are increasingly used in medicine but require more research to fully understand their mechanisms.

research Large-Scale, Multicenter, Prospective Registry Study of Ripretinib in Advanced GIST: A Real-World Study from China

1 citations , June 2023 in “Advances in therapy”

Ripretinib is effective and safe for treating advanced GIST in Chinese patients, particularly for non-gastric GISTs.

research Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study

8 citations , June 2019 in “Journal of Ginseng Research”

Gintonin-enriched fraction promotes hair growth and could be a potential alopecia treatment.

research Specific inhibition of FGF5-induced cell proliferation by RNA aptamers

15 citations , February 2021 in “Scientific Reports”

RNA aptamers can specifically block FGF5-related cell growth, potentially treating related diseases or hair disorders.

research Testosterone stimulates proliferation and inhibits interleukin‐6 production of normal and hereditary gingival fibromatosis fibroblasts

39 citations , May 2002 in “Oral Microbiology and Immunology”

Testosterone increases cell growth and reduces IL-6 in gum cells.

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