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GlossaryFollicle Depth

distance from skin surface to hair follicle base

Follicle depth refers to the distance from the surface of the skin to the base of the hair follicle, where hair growth begins. This measurement is important for understanding hair growth patterns, diagnosing conditions like alopecia, and planning treatments such as hair transplants.

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A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells

research A systematic summary of survival and death signalling during the life of hair follicle stem cells

31 citations , August 2021 in “Stem Cell Research & Therapy”

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

research Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

12 citations , June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

research Induction of Cell Proliferation and Cell Death in Human Follicle Dermal Papilla Cells by Zinc Chloride

2 citations , January 2019 in “Indian Journal of Pharmaceutical Sciences”

Zinc chloride can cause human scalp cells to multiply and die.

research 1391 Cell death functions in hair follicle regeneration

April 2023 in “Journal of Investigative Dermatology”

Proper cell death regulation is crucial for normal hair follicle regeneration and skin remodeling.

research Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo andIn Vitro

140 citations , December 1998 in “Journal of Investigative Dermatology”

Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.

research Apoptotic cell death in canine hair follicle.

5 citations , January 2005 in “PubMed”

Apoptosis is important in the hair cycle of dogs.

research ISID1391 – Cell death functions in hair follicle regeneration

May 2023

research ISID1373 - Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata

April 2023

Higher PD-1 levels mean fewer CD8+ T cells in alopecia areata hair follicles.

Expression of Programmed Cell Death 1 Inversely Correlated With the Density of CD8+ T Cells Infiltrating Hair Follicles in Alopecia Areata

research 1373 Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata

April 2023 in “Journal of Investigative Dermatology”

Higher PD-1 levels are linked to fewer immune cells in hair follicles in alopecia areata.

research Apoptotic cells may drive cell death in hair follicles during their regression cycle

October 2023 in “Oncotarget”

Apoptotic cells help cause hair follicle cell death during regression.

research 880 Gasdermin A3-mediated cell death causes niche collapse and precocious activation of hair follicle stem cells

2 citations , April 2019 in “Journal of Investigative Dermatology”

Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.

research Apoptotic Cells May Drive Cell Death in Hair Follicles During their Regression Cycle

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Apoptotic cells may trigger cell death in hair follicles during their regression cycle.

research VDR is an essential regulator of hair follicle regression through the progression of cell death

1 citations , September 2023 in “Life science alliance”

Vitamin D Receptor is crucial for hair follicle shrinkage and cell death, affecting hair growth.

research Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells.

July 2024 in “PubMed”

Hypoxic preconditioning helps human hair follicle stem cells survive oxidative stress.

Protective Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Dexamethasone-Induced Apoptotic Cell Death in Hair Follicles

research Protective effects of human umbilical cord blood‑derived mesenchymal stem cells against dexamethasone‑induced apoptotic cell death in hair follicles

12 citations , December 2019 in “International Journal of Molecular Medicine”

Stem cells from umbilical cord blood may prevent hair loss caused by certain medications.

research Ultrasonography In Hair Follicle Pathology

November 2014 in “ACTUALIDAD MEDICA”

Ultrasonography can help diagnose and monitor hair loss conditions.

research Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation

30 citations , May 2016 in “International Journal of Cosmetic Science”

Hair loss in women links to inflammation around hair follicles.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

25 citations , September 2014 in “Biological Research”

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

146 citations , May 2002 in “The American journal of pathology”

Cathepsin L is essential for normal hair growth and development.

research Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Hair follicles as a target structure for nanoparticles

59 citations , July 2015 in “Journal of innovative optical health sciences/Journal of innovation in optical health science”

Nanoparticles around 600-700 nm can effectively enter and stay in hair follicles for days, which may help in delivering drugs to specific cells.

research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations , July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.

Biological and Mechanical Influence of Three-Dimensional Microenvironment Formed in Microwell on Multicellular Spheroids Composed of Heterogeneous Hair Follicle Stem Cells

research Biological and mechanical influence of three-dimensional microenvironment formed in microwell on multicellular spheroids composed of heterogeneous hair follicle stem cells

1 citations , December 2023 in “Scientific reports”

3D microenvironments in microwells improve hair follicle stem cell behavior and hair regeneration.

Drug Permeation Through Hair Follicles: Importance and Potential

research Related Topic: Drug Permeation Through Hair Follicles

1 citations , January 2017 in “Springer eBooks”

Hair follicles are important for drug delivery through the skin, but better methods are needed to understand and improve this process.

research Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia

July 2024 in “International Journal of Molecular Sciences”

RF-based therapies might help treat hair loss.

Single-Cell Sequencing Reveals the Intermediate Cell State and Function of Dermal Papilla Cells in the Hair Follicle Cycle of Cashmere Goats

research Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats

May 2020 in “Research Square (Research Square)”

Researchers found four key stages of cell development that are important for hair growth and shedding in cashmere goats.

Effect of Prostaglandin D2 on Hair Follicle Growth and Its Impact on Hair Follicle Stem/Progenitor Cells

research Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage

210 citations , May 2006 in “The FASEB journal”

Oxidative stress causes hair to gray by damaging and killing pigment cells.