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GlossaryGamma-Linolenic Acid

omega-6 fatty acid found in certain plant oils

Gamma-Linolenic Acid (GLA) is an omega-6 fatty acid found in various plant oils, such as evening primrose oil and borage oil. It plays a crucial role in maintaining healthy skin and hair by reducing inflammation and supporting cell structure. GLA is often used in supplements to manage conditions like eczema, psoriasis, and hair loss due to its anti-inflammatory properties.

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Abnormal Essential Fatty Acid Composition of Tissue Lipids in Genetically Diabetic Mice Is Partially Corrected by Dietary Linoleic and Gamma-Linolenic Acids

research Abnormal essential fatty acid composition of tissue lipids in genetically diabetic mice is partially corrected by dietary linoleic and γ-linolenic acids

20 citations , May 1985 in “British journal of nutrition”

Dietary essential fatty acids improved skin and hair conditions and partially corrected fat composition in diabetic mice.

Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction

research Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction

21 citations , April 2012 in “European Journal of Pharmaceutics and Biopharmaceutics”

The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.

research Acne

4 citations , January 2019

Acne is a common skin condition that can be influenced by diet, lifestyle, and hormones, and requires a treatment approach that includes psychological considerations.

research In Vivo Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

32 citations , December 2013 in “Biological & Pharmaceutical Bulletin”

Rice bran extract can potentially treat hair loss by promoting hair growth and increasing the number of hair follicles.

research Deciphering the Skin Anti-Aging and Hair Growth Promoting Mechanisms of Opophytum forskahlii Seed Oil via Network Pharmacology

December 2025 in “International Journal of Molecular Sciences”

Opophytum forskahlii seed oil may help with anti-aging and hair growth.

research TGFβ signaling regulates lipogenesis in human sebaceous glands cells

44 citations , January 2013 in “BMC Dermatology”

TGFβ signaling prevents sebaceous gland cells from producing fats.

research Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

28 citations , January 2018 in “Biochemical Society Transactions”

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

research An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

2 citations , August 2020 in “Cosmetics”

Herbal formula shows promise for hair loss treatment.

research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

research 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid

22 citations , August 2011 in “Journal of Supercritical Fluids”

Rice bran extract might help prevent hair loss.

research Adipocytes in Skin Health and Disease

77 citations , March 2014 in “Cold Spring Harbor Perspectives in Medicine”

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

research Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng

67 citations , February 2020 in “Journal of Ginseng Research”

Korean Red Ginseng has beneficial components that help with stress, immunity, fatigue, memory, blood flow, and disease protection.

research Studies of the modulation of MHC antigen and cell adhesion molecule expression on human dermal papilla cells

August 1994 in “Journal of dermatological science”

Different substances affect hair and skin cell growth in various ways, with some promoting and others inhibiting cell proliferation.

research The effects of extra cellular matrix and growth factors on dermal papilla cell proliferation

August 1994 in “Journal of dermatological science”

Different substances affect hair and skin cell growth in various ways.

Prunus Mira Koehne in Sichuan, China: Recorded History as a Medicine and Food, Modern Applications, Distribution, and Ethnobotanical Investigations

research Prunus mira Koehne in Sichuan, China: Recorded History as a Medicine and Food, Modern Applications, Distribution, and Ethnobotanical Investigations

4 citations , March 2022 in “Frontiers in pharmacology”

Prunus mira Koehne is valuable for hair growth and has potential for sustainable use, but needs more research and conservation.

research Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata

May 2025 in “Frontiers in Pharmacology”

Targeting gut microbiome and metabolome may help treat autoimmune skin diseases like alopecia areata.

The Chemical and Pharmacological Research Progress on Fructus Malvae

research The Chemical and Pharmacological Research Progress on a Kind of Chinese Herbal Medicine, Fructus Malvae

1 citations , September 2022 in “Molecules”

Fructus Malvae may help with diabetes, tumors, and hair loss due to its various active compounds.

research 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

Y27632 increases cell growth through EGFR signaling, not ROCK1/2.

research Physico-Chemical Characteristics of Rosa canina L. Seeds and Determining Their Potential Use

4 citations , December 2024 in “Applied Sciences”

Rosehip seeds have high nutritional value and antioxidant properties, making them useful for health products.

Essential Fatty Acid Deficiency in a Patient with Vascular Ehlers-Danlos Syndrome

research Essential Fatty Acid Deficiency (EFAD) in a Patient with Vascular Ehlers Danlos Syndrome (EDS-4) (P12-053-19)

1 citations , June 2019 in “Current developments in nutrition”

A patient with Ehlers-Danlos Syndrome improved after treatment for fat malabsorption and essential fatty acid deficiency.

research Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

Red light exposure can slow aging in mice by improving fat metabolism.

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

60 citations , December 2013 in “PLoS ONE”

EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.

research Azelaic Acid: Mechanisms of Action and Clinical Applications

34 citations , October 2024 in “Clinical Cosmetic and Investigational Dermatology”

Azelaic acid is effective for treating rosacea, acne, and melasma.

Supercritical CO2 Extraction of Rice Bran Oil: The Technology, Manufacture, and Applications

research Supercritical CO₂ Extraction of Rice Bran Oil –the Technology, Manufacture, and Applications

23 citations , January 2017 in “Journal of Oleo Science”

Supercritical CO2 extraction makes rice bran oil healthier and safer than traditional methods.

Complementarity and Balance of Dietary Protein and Lipid Intake

research Complémentarité et équilibre de l’apport alimentaire en protéines et en lipides

5 citations , January 2003 in “Oilseeds and fats, crops and lipids/OCL. Oilseeds & fats crops and lipids”

Vegetable protein lowers cholesterol and protein deficiency can cause health issues.

Micronutrients for Hair and Nails: A Review of Their Impact on Health

research Micronutrients for Hair and Nails

1 citations , January 2010 in “Springer eBooks”

Certain micronutrients may improve hair and nail health, but more research is needed to confirm their benefits.

research Nutritional factors and hair loss

239 citations , July 2002 in “Clinical and Experimental Dermatology”

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

research Nutritional Management of Menopausal Women

January 2017 in “Springer eBooks”

Eating a balanced diet with specific nutrients can help manage menopause symptoms and prevent related health issues.

Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

research Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome

200 citations , October 2009 in “European journal of endocrinology”

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

research Traditional and Contemporary uses, Phytochemistry and Pharmacology of Psoralea corylifolia Linn.

January 2024 in “Journal of Ayurveda Campus”

Psoralea corylifolia Linn. is a medicinal plant used for skin diseases and has various health benefits.