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GlossaryEtiopathogenesis

study of disease causes and development mechanisms

Etiopathogenesis refers to the study of the causes and development of a disease. It combines "etiology," which is the investigation of the cause or origin of a disease, and "pathogenesis," which describes the biological mechanisms that lead to the diseased state. For example, in the context of alopecia, etiopathogenesis would involve understanding both the genetic and environmental factors that trigger hair loss and the biological processes that result in the thinning or shedding of hair.

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research Update on the pathogenesis, genetics and medical treatment of patterned hair loss.

19 citations , November 2010 in “PubMed”

New genetic insights have improved understanding of hair loss, leading to a new test and treatments, but more research is needed on the test and laser comb effectiveness.

research PATHOGENESIS OF GENETIC HUMAN HAIR DISORDERS

1 citations , August 1981 in “The Journal of Dermatology”

All major hair defects involve cuticle abnormalities.

research Studying the genetic predisposing factors in the pathogenesis of acne vulgaris

39 citations , May 2011 in “Human Immunology”

Genetics play a role in acne, but how exactly they contribute is not fully understood.

research What does acne genetics teach us about disease pathogenesis?

29 citations , March 2019 in “British Journal of Dermatology”

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

research Updated strategies for the management, pathogenesis and molecular genetics of different forms of ichthyosis syndromes with prominent hair abnormalities

3 citations , September 2017 in “Archives of dermatological research”

Early diagnosis and tailored treatments are crucial for managing ichthyosis syndromes with hair abnormalities.

research Genetic analysis of the role of androgen metabolism in the pathogenesis of prostate cancer

December 2004 in “SUNScholar (Stellenbosch University)”

Certain genetic markers can indicate a person's risk of developing prostate cancer.

research A Monoallelic Two-Hit Mechanism in PLCD1 Explains the Genetic Pathogenesis of Hereditary Trichilemmal Cyst Formation

21 citations , October 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.

research Isolated autosomal recessive woolly hair/hypotrichosis: genetics, pathogenesis and therapies

9 citations , May 2021 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Topical minoxidil may help treat a rare genetic hair condition with no fully effective treatments yet.

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations , October 2010 in “The American Journal of Pathology”

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

research THE PATHOGENESIS OF ALOPECIA AREATA

89 citations , October 1996 in “Dermatologic Clinics”

Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.

research 7 Pathogenesis and Classification of Male Pattern Hair Loss (Androgenic Alopecia)

October 2022 in “Hair Transplantation”

Male pattern hair loss is mainly caused by genetics and hormones, especially DHT.

research Hidradenitis suppurativa: pathogenesis and management

238 citations , July 2003 in “British Journal of Plastic Surgery”

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

research The genetics of alopecia areata: What's new and how will it help our patients?

43 citations , May 2011 in “Dermatologic therapy”

New genetic discoveries in alopecia areata could lead to better treatments.

research Alopecia Areata: Pathogenesis, Diagnosis, and Therapies

21 citations , April 2025 in “MedComm”

Alopecia areata causes unpredictable hair loss, and more research is needed to fully understand and treat it effectively.

research Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences

April 2024 in “International journal of molecular sciences”

Alopecia areata and vitiligo share immune system dysfunction but differ in specific immune responses and affected areas.

research Pathogenesis of androgenetic alopecia

July 2022

Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.

research Deciphering the pathogenesis of central centrifugal cicatricial alopecia

September 2019

Mutations in the PADI3 gene may cause central centrifugal cicatricial alopecia in women of African ancestry.

research Pathogenesis and clinical features of alopecia in epidermolysis bullosa: A systematic review

June 2019 in “Pediatric Dermatology”

Alopecia in patients with epidermolysis bullosa varies in severity and is often caused by skin blistering or trauma.

research Pathogenesis of androgenetic alopecia

March 2019 in “Chinese Journal of Dermatology”

Hair loss, known as androgenetic alopecia, is mainly caused by genetics, but also by hormone imbalances, shrinking hair follicles, inflammation, and environmental factors.

research Spinal and bulbar muscular atrophy: pathogenesis and clinical management

42 citations , May 2013 in “Oral Diseases”

Kennedy's disease leads to muscle weakness without a cure, but exercise and managing symptoms may help patients live a normal lifespan.

research An update of the pathogenesis of frontal fibrosing alopecia: What does the current evidence tell us?

23 citations , October 2018 in “Australasian Journal of Dermatology”

The current understanding of frontal fibrosing alopecia involves immune, genetic, hormonal factors, and possibly environmental triggers, but more research is needed for effective treatments.

The Etiology and Pathogenesis of Alopecia Areata

research The aetiology and pathogenesis of alopecia areata

17 citations , July 1994 in “Journal of Dermatological Science”

The cause of alopecia areata is likely a mix of genetics, immune system issues, and environmental factors, with more research needed to understand it fully.

research How Our Microbiome Influences the Pathogenesis of Alopecia Areata

4 citations , October 2022 in “Genes”

Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.

research Advances in the Molecular Pathogenesis and Targeted Therapy of Psoriasis

May 2025 in “Galen Medical Journal”

New targeted therapies for psoriasis show promise but face challenges like side effects and treatment resistance.

Patched-Associated Tumors: Modifier Genes and Pathogenesis

research Patched-assoziierte Tumoren: Modifikatorgene und Pathogenese

February 2022

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

research 284 Deciphering the pathogenesis of central centrifugal cicatricial alopecia

September 2019 in “Journal of Investigative Dermatology”

CCCA in women of African ancestry may be caused by PADI3 gene mutations and intense hair grooming.

research Alopecia Areata: a Comprehensive Review of Pathogenesis and Management

99 citations , July 2017 in “Clinical Reviews in Allergy & Immunology”

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

61 citations , January 2019 in “American Journal of Clinical Dermatology”

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

research Polycystic ovarian syndrome: current understanding of pathogenesis, diagnosis and treatment

5 citations , October 2021 in “Meditsinskiy sovet = Medical Council”

PCOS treatment should be personalized based on its type and the patient's reproductive goals.

research Does Complement Have a Role in the Pathogenesis of Alopecia Areata?

1 citations , January 2018 in “Skin appendage disorders”

The complement system might be involved in the development of alopecia areata and could lead to new treatments.