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Did you mean Glycogen Synthase Kinase 3?

GlossaryGlycogen Synthase Kinase 3

enzyme involved in regulating cell functions and signaling pathways

Glycogen Synthase Kinase 3 (GSK-3) is an enzyme that plays a crucial role in various cellular processes, including the regulation of glycogen synthesis, cell division, and cell survival. It is involved in multiple signaling pathways and can influence conditions like diabetes, Alzheimer's disease, and even hair growth by affecting cellular functions and gene expression.

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Vitamin B12 Activates the Wnt-Pathway in Human Hair Follicle Cells by Induction of Beta-Catenin and Inhibition of Glycogen Synthase Kinase-3 Transcription

research Vitamin B12 Activates the Wnt-Pathway in Human Hair Follicle Cells by Induction of <i>beta</i>-Catenin and Inhibition of Glycogensynthase Kinase-3 Transcription

4 citations , January 2011 in “Journal of Cosmetics, Dermatological Sciences and Applications”

Vitamin B12 may promote hair growth by affecting certain cell processes.

research Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study

February 2025 in “Journal of Receptors and Signal Transduction”

EGCG may help regrow hair by inhibiting a specific enzyme.

Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

research Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells

July 2023 in “Current Issues in Molecular Biology”

Escin may help treat hair loss by boosting a specific cell growth pathway.

research Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase–Protein Kinase B–Glycogen Synthase Kinase 3β Signaling

14 citations , June 2022 in “Neuroscience”

research Discovery and Optimization of Novel Pyridines as Highly Potent and Selective Glycogen Synthase Kinase 3 Inhibitors

October 2019

New pyridine compounds effectively inhibit GSK3, a diabetes treatment target.

research Human placental extract exerts hair growth-promoting effects through the GSK-3β signaling pathway in human dermal papilla cells

20 citations , August 2015 in “International Journal of Molecular Medicine”

Human placental extract may help hair growth by affecting certain cell signals and could be more effective with minoxidil.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations , May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia

95 citations , January 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice

research Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice

23 citations , January 2018 in “International Journal of Molecular Medicine”

Baicalin helps hair growth by activating specific cell signals and pathways.

research Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cells

21 citations , November 2015 in “Phytomedicine”

Glycyrrhizic acid may help reduce unwanted hair growth.

research Sustained release of inhibitor from bionic scaffolds for wound healing and functional regeneration

8 citations , January 2020 in “Biomaterials Science”

Researchers developed a scaffold that releases a healing drug over time, improving wound healing and skin regeneration.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)

6 citations , May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

research Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells

2 citations , May 2023 in “Plants”

Allium hookeri extract may help promote hair growth and protect cells from damage.

research Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via Gsk3β Down-Regulation

1 citations , October 2025 in “Current Issues in Molecular Biology”

Escin improves skin blood flow and health by enhancing blood vessel networks.

Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

research Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways

May 2024 in “Archives of dermatological research”

Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.

Effect of Fermented Mackerel Oil on Hair Growth

research 290 Effect of fermented mackerel oil on the hair growth

September 2017 in “Journal of Investigative Dermatology”

Fermented mackerel oil was found to promote hair growth by activating certain cell signals and increasing cell growth.

research Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of Gsk3β Activity in Cultured Human Dermal Papilla Cells

March 2022 in “Molecules”

Adenosine can help treat hair loss by promoting hair growth.

Faculty Opinions Recommendation of Topical Valproic Acid Increases the Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

research Faculty Opinions recommendation of Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis.

July 2014 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Applying valproic acid on the scalp increased hair growth in men with hair loss.

research GSK-3 Inhibitors: Recent Developments and Therapeutic Potential

3 citations , September 2008 in “Current signal transduction therapy”

Drugs that block GSK-3 show promise for treating various diseases.

The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis

9 citations , April 2006 in “American Journal of Pathology”

SGK3 is essential for proper hair growth and health.

Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations , June 2018 in “Frontiers in pharmacology”

Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.

research Effects of dihydrotestosterone on rat dermal papilla cells in vitro

19 citations , April 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

research Phosphatidylinositol 3-Kinase/Akt-Dependent and -Independent Protection Against Apoptosis in Normal Human Melanocytes

16 citations , October 2004 in “Journal of Investigative Dermatology”

Normal human melanocytes can avoid cell death through multiple pathways.

research The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits

April 2020

Ocu-miR-205 affects hair density in Rex rabbits by influencing cell processes and signaling pathways.

Tumor Heterogeneity of Prostate Cancer and SARS-CoV2 Infection: A Complex Relationship Involving Extracellular Vesicles and the Androgen Receptor

research Hétérogénéité tumorale du cancer de la prostate et infection par le SARS-CoV2 : une relation complexe impliquant les vésicules extracellulaires et le récepteur des androgènes

June 2023 in “SPIRE - Sciences Po Institutional REpository”

Extracellular vesicles and androgen receptors may help identify prostate cancer resistance and reduce SARS-CoV-2 infection.