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Did you mean Hematopoietic Cell E-/L-Selectin Ligand?

GlossaryHematopoietic Cell E-/L-Selectin Ligand

molecule on blood-forming cells aiding their movement along vessels

Hematopoietic Cell E-/L-Selectin Ligand is a molecule found on the surface of blood-forming cells (hematopoietic cells) that helps these cells stick to and move along blood vessel walls. This interaction is crucial for the cells to travel to different parts of the body, especially during immune responses or when the body is repairing tissues.

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ZO-1 Boosts the In Vitro Self-Renewal of Pre-Haematopoietic Stem Cells from OCT4-Reprogrammed Human Hair Follicle Mesenchymal Stem Cells Through Cytoskeleton Remodeling

research ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling

December 2024 in “Stem Cell Research & Therapy”

ZO-1 helps hair follicle stem cells renew better by changing their structure.

research Genetic Fate Mapping Using Site-Specific Recombinases

29 citations , January 2010 in “Methods in Enzymology”

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.

research c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer

4 citations , January 2021 in “Journal of Clinical Medical Research”

c-Kit is important for heart regeneration and cancer development.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

Role of β-Catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer

research Role of -catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer

61 citations , January 2008 in “Cold Spring Harbor Symposia on Quantitative Biology”

Beta-catenin is crucial for skin cell growth, development, and cancer formation.

Differences in Cell Subsets Between Sun-Exposed and Unexposed Skin: Preliminary Single-Cell Sequencing and Biological Analysis from a Single Case

research Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case

3 citations , October 2024 in “Frontiers in Medicine”

Sun-exposed skin shows different cell activity and gene expression, suggesting targets to prevent skin aging and cancer.

Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

research Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

research Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/− Mice

8 citations , March 2014 in “American Journal of Pathology”

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

research Stem Cells in the Body

November 2017

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

The Effect of Glycyrrhizic Acid and Aqueous Licorice Extract on Hair Growth Retardation: In Vitro Mechanistic and Efficacy Studies in Human

research The effect of glycyrrhizic acid and aqueous licorice extract on hair growth retardation : in vitro mechanistic and efficacy studies in human

January 2016

Glycyrrhizic acid and licorice extract can significantly reduce unwanted hair growth.

Graft-Versus-Host Disease: Comprehensive Overview by the American Academy of Dermatology

research Graft-versus-host disease

58 citations , April 2012 in “Journal of the American Academy of Dermatology”

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

research FOXN1 deficient nude severe combined immunodeficiency

32 citations , January 2017 in “Orphanet journal of rare diseases”

FOXN1 gene mutations cause a rare, severe immune disease treatable with cell or tissue transplants.

research Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

56 citations , March 2015 in “Cell death and differentiation”

Older skin has higher cancer risk due to inflammation and stem cell issues.

research Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

124 citations , February 2018 in “Nature Reviews Genetics”

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

research Differential expression of stem cell markers in human follicular bulge and interfollicular epidermal compartments

28 citations , March 2010 in “Histochemistry and Cell Biology”

Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.

research Hematopoietic Stem Cells: Nature and Niche Nurture

2 citations , May 2021 in “Bioengineering”

Blood stem cells are diverse, influenced by many factors, and understanding them is key for progress in regenerative medicine.

research The Harmonies Played by TGF-β in Stem Cell Biology

156 citations , December 2012 in “Cell Stem Cell”

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

research Hardwiring Stem Cell Communication through Tissue Structure

82 citations , March 2016 in “Cell”

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

research Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

60 citations , September 2023 in “Science”

BTNL proteins help control inflammatory bowel disease by maintaining specific immune cells.

Characterization of CD4+ Stem Cells of the Skin and Their Role in Skin Homeostasis and Tumorigenesis

research Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis

1 citations , January 2021

CD4+ skin cells may be precursors to basal cell carcinoma.

research Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3

8 citations , February 2015 in “Cellular immunology”

Deleting Snai2 and Snai3 causes fatal autoimmunity.

research Melanocyte Chitosan/Gelatin Composite Fabrication with Human Outer Root Sheath-Derived Cells to Produce Pigment

5 citations , March 2019 in “Scientific Reports”

The technique can isolate cells to help treat skin pigmentation issues.

research Stem Cell Therapies for Epidermolysis Bullosa Treatment

22 citations , March 2023 in “Bioengineering”

Stem cell therapies may help improve symptoms and quality of life for people with epidermolysis bullosa.

research Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds

30 citations , November 2019 in “Genetics selection evolution”

Chinese domestic goats have unique genetic traits due to domestication and geographic isolation.

Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations

research Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg–like Cells, and Common EGFR Somatic Mutations

4 citations , May 2021 in “The American Journal of Surgical Pathology”

Cutaneous Lymphadenoma is a unique skin tumor with specific protein markers and common gene mutations that may cause continuous cell growth.

research Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Aged individuals heal wounds less effectively due to specific immune cell issues.

research TGFβ and cancer metastasis: an inflammation link

55 citations , April 2010 in “Cancer and Metastasis Reviews”

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

research RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

42 citations , December 2011 in “The journal of immunology/The Journal of immunology”

RANKL causes lymph nodes to grow by making certain cells multiply.

research Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Different types of inactive melanocyte stem cells exist with unique characteristics and potential to develop into other cells.

Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

research Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis

53 citations , August 2019 in “American journal of human genetics”

FOXN1 gene variants cause low T cells and immune issues from birth.