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research Interleukin‐1 family cytokines and soluble receptors in hidradenitis suppurativa

3 citations , September 2024 in “Experimental Dermatology”

This study investigates the role of IL-1 family cytokines in hidradenitis suppurativa (HS) by analyzing serum levels in 16 HS patients and 16 healthy controls. The findings reveal that IL-18 and free IL-18 levels are significantly higher in HS patients and correlate strongly with disease severity, as measured by the International HS Severity Score System (IHS4). Additionally, soluble inhibitors such as IL-1Ra, IL-1R2, and ST2/IL-1R4 are elevated in patients. The study suggests that IL-18 could serve as a novel serum biomarker for active HS, highlighting the involvement of IL-1F cytokines in the disease's mediation and severity.

research Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation

79 citations , December 1999 in “Mechanisms of Development”

Whn is crucial for hair growth in certain areas by controlling a specific gene.

research ACKR2 limits skin fibrosis and hair loss through IFN‐β

10 citations , September 2021 in “The FASEB Journal”

ACKR2 helps prevent skin scarring and hair loss by controlling inflammation.

GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

39 citations , March 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

GLI2 increases follistatin production in human skin cells.

research HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond

30 citations , July 2019 in “Endocrinology”

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

research The Fate of Trichohyalin

135 citations , October 1997 in “Journal of biological chemistry/The Journal of biological chemistry”

Trichohyalin is modified by enzymes to form strong structures in hair cells.

research Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells

35 citations , April 2009 in “Journal of Neuroscience Research”

HDAC inhibitors help brain cells grow and improve brain function.

research Hair Cycle-Dependent Expression of Hepatocyte Growth Factor (HGF) Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of HGF in Rat Hair Follicles

33 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

research Co-expression of PADI isoforms during progenitor differentiation enables functional diversity

2 citations , October 2023 in “Philosophical Transactions of the Royal Society B Biological Sciences”

Different PADI isoforms help cells develop diverse functions.

research Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapies

39 citations , October 2012 in “Familial cancer”

New therapies for Birt–Hogg–Dubé syndrome are being developed based on understanding the FLCN gene's role.

research Characterization of Primary Cilia and Intraflagellar Transport 20 in the Epidermis

1 citations , January 2020

Ift20 is essential for hair follicle function and skin cell movement.

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

181 citations , January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research 675 Hair loss in hephaestin knockout mice is associated with iron deficiency

April 2016 in “Journal of Investigative Dermatology”

Iron deficiency causes hair loss by affecting hair differentiation and cycling.

research Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

22 citations , August 2021 in “Frontiers in medicine”

Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.

research 855 Targeted deletion of crif1 in mouse skin epidermis impairs skin homeostasis

April 2017 in “Journal of Investigative Dermatology”

Removing the Crif1 gene in mouse skin disrupts skin balance and hair growth.

research 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa

2 citations , September 2017 in “Journal of Investigative Dermatology”

Notch1 signaling is impaired in hidradenitis suppurativa, affecting skin and hair cells.

research [Molecular cloning of full-long cDNA sequences encoding hairless gene in the Kunming mouse].

November 2005 in “PubMed”

The hairless gene in Kunming mice is important for hair and skin, and shows genetic variations.

research Long-read RNA sequencing reveals extensive transcript isoform changes in a patient with IFAP syndrome with a recurrent intronic MBTPS2 variant

April 2026 in “Human Genome Variation”

Long-read RNA sequencing can identify complex gene changes in IFAP syndrome.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations , September 2006 in “Cell Cycle”

The HR protein's role as a repressor is essential for controlling hair growth.

research Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration

4 citations , January 2022 in “Australasian Journal of Dermatology”

Higher HDAC1 levels in alopecia areata suggest HDAC inhibitors might help treat it and acne.

research Two Different Mutations in the Same Codon of a Type II Hair Keratin (hHb6) in Patients with Monilethrix

20 citations , December 1999 in “Journal of Investigative Dermatology”

Mutations in the hHb6 gene cause the hair disorder monilethrix.

research Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function

10 citations , November 2023 in “Science Immunology”

Super-enhancers control CD25 expression in specific cell types, affecting immune function.

research A novel missense mutation in the mouse hairless gene causes irreversible hair loss: Genetic and molecular analyses of Hrm1Enu

18 citations , February 2006 in “Genomics”

A new genetic mutation in mice causes permanent hair loss and skin wrinkling.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

47 citations , December 2011 in “Experimental Dermatology”

CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.

research Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration

10 citations , November 2020 in “American Journal Of Pathology”

Integrin β1 is crucial for liver structure and function, preventing fibrosis.

The Effects of Sonic, Desert, and Indian Hedgehog Signaling in Skin

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