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Did you mean Histone Deacetylases?

GlossaryHistone Deacetylases

enzymes that remove acetyl groups from histone proteins

Histone Deacetylases (HDACs) are enzymes that remove acetyl groups from histone proteins, leading to a more compact and less accessible form of DNA. This process can suppress gene expression by making it harder for transcription factors to access the DNA. HDACs play a crucial role in regulating gene activity and are involved in various biological processes, including cell cycle progression and differentiation.

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research Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells

35 citations , April 2009 in “Journal of Neuroscience Research”

HDAC inhibitors help brain cells grow and improve brain function.

research Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis

32 citations , June 2013 in “Journal of Investigative Dermatology”

Mice without certain skin proteins had abnormal skin and hair development.

research Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System

8 citations , October 2019 in “The Journal of surgical research/Journal of surgical research”

Sodium valproate helps skin healing by affecting GABA and histone deacetylase.

research Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration

4 citations , January 2022 in “Australasian Journal of Dermatology”

Higher HDAC1 levels in alopecia areata suggest HDAC inhibitors might help treat it and acne.

research HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy

January 2024 in “Theranostics”

HDAC6 helps keep ovarian follicles dormant, extending female fertility.

research Epigenetic control of adult stem cell function

179 citations , July 2016 in “Nature Reviews Molecular Cell Biology”

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

research The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

178 citations , October 2001 in “Genes & Development”

The mutated hairless gene causes hair loss by acting as a new type of corepressor affecting thyroid hormone receptors.

Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

research Short-Chain Fatty Acids from Cutibacterium acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

70 citations , February 2019 in “The journal of immunology/The Journal of immunology”

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

research Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness

51 citations , November 2011 in “British Journal of Dermatology”

A gene called HDAC9 might be a new factor in male-pattern baldness.

research Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients

48 citations , June 2014 in “Neurobiology of Disease”

The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.

research Valproic acid promotes human hair growth in in vitro culture model

48 citations , June 2013 in “Journal of Dermatological Science”

Valproic acid may help hair grow and could be a safe treatment for hair loss.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

research Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle

22 citations , April 2010 in “Journal of Cellular Biochemistry”

Certain mutations in the hairless protein disrupt its ability to regulate the hair cycle.

research TSA restores hair follicle-inductive capacity of skin-derived precursors

18 citations , February 2019 in “Scientific Reports”

Trichostatin A helps restore hair-growing ability in skin cells used for hair regeneration.

research Small RNAs Loom Large During Reprogramming

18 citations , June 2011 in “Cell stem cell”

MicroRNAs can reprogram cells into stem cells faster and more efficiently than traditional methods.

research Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms

18 citations , October 2009 in “Endocrinology”

Different Hairless isoforms affect Vitamin D receptor activity in hair regulation, with one repressing and the other stimulating it.

research Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation

16 citations , April 2024 in “Proceedings of the National Academy of Sciences”

HDAC4 and HDAC7 are crucial for Th17 cell development and could be targeted to treat inflammatory diseases.

research Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells

6 citations , December 2021 in “Scientific Reports”

Inhibiting class I HDACs helps maintain hair growth ability in skin cells.

research Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles

4 citations , November 2020 in “BMC Dermatology”

Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.

research Second International Symposium—Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases

2 citations , June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Epigenetic factors play a crucial role in skin health and disease.

research Hairless protein of Jumonji family and hair loss

January 2009

Mutations in the hairless protein gene cause hair loss.

research Genetics of Alopecia

April 2012 in “Encyclopedia of Life Sciences”

Different genes are linked to various types of hair loss.

research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease

January 2018 in “Stem cell biology and regenerative medicine”

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.

research Sirtuins pathways and redox homeostasis: a pilot study on young and old monozygotic twins

August 2015 in “Free Radical Biology and Medicine”

The study suggests that higher levels of SIRT1 and SIRT2 may improve overall cell health and aging processes.

research SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata

13 citations , May 2023 in “Journal of Dermatological Science”

Reduced SIRT1 in hair cells may cause alopecia areata by triggering immune responses.

research Targeting cardiac hypertrophy through a nuclear co‐repressor

3 citations , October 2019 in “EMBO molecular medicine”

Targeting NCoR1 can help treat heart enlargement and dysfunction.

research Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

1 citations , May 2022 in “Research Square (Research Square)”

Acetate helps reduce depression in rats with PCOS by lowering specific gene expression and DNA changes in the brain.

research Redox-directed interventions targeting skin photodamage

August 2015 in “Free Radical Biology and Medicine”

Some treatments can improve skin's defense against damage, but overuse may cause other skin problems.

research Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

667 citations , May 2008 in “Genes & Development”

Histone demethylases can change gene expression and may be linked to diseases like cancer.