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Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research Anti-Zika Activity of a Library of Synthetic Carbohydrate Receptors

11 citations , March 2019 in “Journal of Medicinal Chemistry”

Some synthetic carbohydrate receptors, especially compounds 3 and 15, show strong potential for treating Zika virus.

research Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color

10 citations , September 2020 in “Metabolites”

Hair color and length affect metabolite profiles in hair, so they should be considered in hair analysis.

research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

9 citations , January 2017 in “Organic Process Research & Development”

In 2017, a new method was created to efficiently produce a topical antiandrogen, a compound used to treat excess sebum and acne, with a high yield and purity.

research New fluorogenic probes for neutral and alkaline ceramidases

5 citations , March 2019 in “Journal of lipid research”

New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research In silico analysis of ethyl acetate Bruguiera gymnorhiza leaf extracts as an anti-inflammatory agent

4 citations , September 2024 in “Jurnal Pengolahan Hasil Perikanan Indonesia”

Bruguiera gymnorhiza leaf extracts show potential for developing anti-inflammatory drugs.

Imaging Prostate Cancer With Technetium-99m Tricarbonyl Finasteride Dithiocarbamate

research Imaging prostate cancer (PCa) with [^99m Tc(CO)₃ ]finasteride dithiocarbamate

4 citations , March 2018 in “Journal of labelled compounds & radiopharmaceuticals”

A new compound was effective for imaging prostate cancer in rats.

research Alternative synthesis of the anti-baldness compound RU58841

4 citations , January 2014 in “RSC Advances”

A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana

3 citations , July 2020 in “Synthetic and Systems Biotechnology”

Scientists improved an enzyme to better produce a hair growth-promoting chemical from an immunosuppressant.

research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate

3 citations , January 2003 in “Synthetic Communications”

Scientists made two new chemicals that might help treat diseases caused by male hormones.

research Determination of illegal adulteration of dietary supplements with synthetic hair-growth compounds by UPLC and LC-Q-TOF/MS

2 citations , November 2017 in “Food Additives & Contaminants: Part A”

The new method accurately detects illegal hair-growth drugs in dietary supplements.

research In Vitro Hair Dermal Papilla Cells Induction by Fagraea berteroana, a Tree of the Marquesan Cosmetopoeia (French Polynesia)

1 citations , February 2021 in “Cosmetics”

Fagraea berteroana fruit extract may promote hair growth by affecting cell proliferation and hair growth pathways.

research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs

1 citations , February 2014 in “Archiv Der Pharmazie”

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

research Polarized microscopy in genetic hair disorders: case series

January 2025

Polarized microscopy helps identify hair irregularities in genetic disorders.

A Panoramic Review on Ethnomedicinal, Therapeutic, Phytochemical, and Advance Attributes of the Genus Ziziphus Mill., Native to Pakistan

research A panoramic review on ethnomedicinal, therapeutic, phytochemical, and advance attributes, of the genus Ziziphus Mill., native to Pakistan

1 citations , June 2023 in “Ethnobotany research and applications”

The review concludes that the Ziziphus species, especially jujube, may promote hair growth and have various health benefits, warranting more research.