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Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

Hydroxychloroquine Modulates the Progression of Experimentally Induced Benign Prostatic Hyperplasia in Rats via Targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL Pathways: Computational and In Vivo Studies

research Hydroxychloroquine modulates the progression of experimentally induced benign prostatic hyperplasia in rats via targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL pathways: computational and in vivo studies

1 citations , June 2025 in “Scientific Reports”

Hydroxychloroquine may help treat benign prostatic hyperplasia by reducing inflammation and promoting cell death.

Therapeutic Targeting of Ocular Diseases with Emphasis on PI3K/Akt and OPRL Pathways by Hedera Helix L. Saponins: A New Approach for the Treatment of Pseudomonas Aeruginosa-Induced Bacterial Keratitis

research Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by Hedera helix L. saponins: a new approach for the treatment of Pseudomonas aeruginosa-induced bacterial keratitis

1 citations , May 2025 in “Natural Products and Bioprospecting”

PEVIII is a promising treatment for Pseudomonas aeruginosa keratitis.

Therapeutic Effects of Human Amniotic Mesenchymal Stem Cell-Derived Exosomes on Stem Cell Proliferation in Irradiated Salivary Glands via the Wnt Pathway

research Therapeutic effects of human amniotic mesenchymal stem cell-derived exosomes on stem cell proliferation in irradiated salivary glands via the Wnt pathway

January 2026 in “Open Life Sciences”

Exosomes from stem cells help repair irradiated salivary glands by boosting cell growth.

KRT17 Promotes Endometrial Cancer Cell Migration and Angiogenesis by Regulating HIF-1α/VEGF Pathway

research KRT17 promotes endometrial cancer cell migration as well as angiogenesis by regulating HIF-1α/VEGF pathway

January 2023 in “European journal of gynaecological oncology”

KRT17 may be a new target for endometrial cancer treatment because it helps cancer cells move and form new blood vessels.

Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

research Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation

13 citations , October 2013 in “The Journal of Dermatology”

Cepharanthine may help hair growth by increasing IGF-I in scalp cells.

Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

research Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway

33 citations , December 2023 in “Cell Death Discovery”

Cepharanthine may help treat gastric cancer by causing cancer cell death and affecting energy use.

research Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway

4 citations , May 2023 in “Research Square (Research Square)”

Cepharanthine can potentially treat gastric cancer by stopping tumor growth.

Network Pharmacology and In Vivo Experimental Analysis for Validating the Antifibrotic Potential of Punica Granatum Leaves Against Skin Scleroderma: The Role of Oxidative Stress, Inflammation and TGF-β1/Snail 1/p-Smad 3 Signaling Pathway

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

This study explores the antifibrotic potential of Punica granatum ethanolic leaf extract (PGEL) against skin scleroderma, focusing on oxidative stress, inflammation, and the TGF-β1/Snail 1/p-Smad 3 signaling pathway. In a rat model with 24 subjects, PGEL was administered at doses of 200 and 400 mg/kg, resulting in reduced oxidative stress and inflammation markers, such as IL-17 A, TNF-α, and MMP-9. PGEL also downregulated fibrotic markers like COL1A1 and Snail 1, and decreased TGF-β1 and p-Smad 3 levels, leading to improved dermal thickness and collagen fiber arrangement. The study suggests that PGEL, rich in compounds like ellagic acid and catechin-3-O-gallate, may offer therapeutic benefits for skin fibrosis by targeting inflammation, extracellular matrix production, and oxidative stress.

research Lgr5 Stem Cells and Potential Treatments for Hair Loss

January 2026 in “Theoretical and Natural Science”

Targeting Lgr5+ stem cells and Wnt signaling may effectively treat hair loss.

research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport

December 2023 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

research Epidermal homeostasis: a balancing act of stem cells in the skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research MOUSE MODELS FOR THE STUDY OF HUMAN HAIR LOSS

36 citations , October 1996 in “Dermatologic Clinics”

Mice are useful for researching human hair loss and testing treatments, despite some differences between species.

research UVB-induced depletion of donor-derived dendritic cells prevents allograft rejection of immune-privileged hair follicles in humanized mice

6 citations , November 2018 in “American journal of transplantation”

UV light helped human hair transplants survive in mice without broad immunosuppression.

research P62 Pre-clinical pharmacological and skin penetration profile of LDE255, a novel and specific Smoothened antagonist

June 2010 in “Melanoma research”

LDE225 is a promising skin-applied treatment for basal cell carcinoma with good skin penetration and effectiveness.

research Diverse cellular players orchestrate regeneration after wounding

7 citations , November 2020 in “Experimental Dermatology”

Different cell types work together to repair skin, and targeting them may improve healing and reduce scarring.

research SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation

April 2026 in “Cellular and Molecular Immunology”

SPT6 prevents excessive skin inflammation by blocking a feedback loop.

Inflammatory Implications In Female Pattern Hair Loss: Unraveling B Cell-Related Immune Activation Through Comparative Transcriptome Profiling

research 0037 Inflammatory implications in female pattern hair loss: unraveling B cell-related immune activation through comparative transcriptome profiling

July 2025 in “Journal of Investigative Dermatology”

Immune system changes may contribute to female pattern hair loss.

research Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails

179 citations , October 2018 in “American Journal of Clinical Dermatology”

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.