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Did you mean Inflammatory Pathways?

GlossaryInflammatory Pathways

molecular signals triggering the body's response to harmful stimuli

Inflammatory pathways, also known as inflammatory signaling pathways, are a series of molecular signals and reactions that the body uses to respond to harmful stimuli, such as pathogens, damaged cells, or irritants. These pathways involve various cells and proteins, including cytokines and chemokines, which work together to initiate and regulate inflammation, ultimately aiming to protect and heal the body. Understanding these pathways is crucial for developing treatments for conditions like alopecia, where inflammation can play a significant role in hair loss.

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Particulate Matter Exposure Induces Maternal Scalp Hair Loss After Birth in C57/B6 Mouse via Alteration of Inflammatory and Apoptotic Pathways

research Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways

May 2026 in “Frontiers in Endocrinology”

Exposure to particulate matter worsens postpartum hair loss by affecting inflammation and cell death pathways.

research Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats

4 citations , April 2022 in “Evidence-based Complementary and Alternative Medicine”

Dracorhodin perchlorate helps heal wounds in diabetic rats by reducing inflammation.

research miR‐200a‐3p in Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Attenuates UVB‐Induced Skin Inflammatory Response and Oxidative Stress via Keap1‐Nrf2 Pathway

January 2025 in “Stem Cells International”

Exosomes from stem cells can reduce UV-induced skin damage by lowering inflammation and oxidative stress.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

The High-Polarity Fraction of Tail Fat Derived from Lanzhou Fat-Tailed Sheep Enhances Skin Wound Healing Through the Regulation of Inflammatory Factors and the TGF-β1/Smad3 Signaling Pathway

research The high-polarity fraction of tail fat derived from Lanzhou Fat-Tailed sheep enhances skin wound healing through the regulation of inflammatory factors and the TGF-β1/Smad3 signaling pathway

June 2026 in “Food Science and Human Wellness”

Tail fat from Lanzhou Fat-Tailed sheep helps heal skin wounds by reducing inflammation and promoting tissue repair.

research The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations , June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

research i-PRF-Derived Exosomes Promote Hair Regeneration by Modulating Inflammatory, Oxidative, Angiogenic, and Regenerative Pathways in an Androgenetic Alopecia Mouse Model

February 2026 in “Trends in Sciences”

i-PRF-derived exosomes can effectively promote hair growth and improve hair health in androgenetic alopecia.

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

research Drugs targeting the JAK/STAT pathway for the treatment of immune-mediated inflammatory skin diseases: protocol for a scoping review

17 citations , May 2019 in “BMJ Open”

JAK/STAT inhibitors show promise for skin diseases but aren't yet approved.

research The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19

15 citations , July 2022 in “Frontiers in Pharmacology”

Cepharanthine may help treat COVID-19 by targeting similar pathways as other inflammatory diseases.

Alleviation of Androgenetic Alopecia with Aqueous Paeonia Lactiflora and Poria Cocos Extract Intake Through Suppressing the Steroid Hormone and Inflammatory Pathway

research Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway

4 citations , November 2021 in “Pharmaceuticals”

Paeonia lactiflora and Poria cocos extracts can potentially increase hair growth and reduce hair loss symptoms by lowering testosterone and inflammation levels.

research Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways

9 citations , February 2025 in “Journal of Nanobiotechnology”

Biomimetic nanovesicles can speed up diabetic wound healing by regulating immune cell behavior and metabolism.

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1

1 citations , February 2023 in “International Journal of Molecular Sciences”

Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.

research BH17 Bridging the gap: identifying dual-targeting therapies for patients with alopecia areata and coexisting immune-mediated inflammatory diseases

June 2025 in “British Journal of Dermatology”

Dual-targeting therapies like Janus kinase inhibitors may treat both alopecia areata and other immune diseases.

Skin Microbiota Ameliorates Androgenetic Alopecia by Harmonizing Skin Immuno-Inflammatory Balance

research Skin bacteriota ameliorates androgenetic alopecia via harmonizing skin immuno inflammatory balance

March 2026 in “Brazilian Journal of Microbiology”

Restoring skin bacteria may help reduce hair loss.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations , July 2015 in “Journal of Immunology”

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

research Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review)

18 citations , July 2021 in “Molecular Medicine Reports”

The WNT signaling pathway is crucial for mesenchymal stem cells' function and therapy success.

research Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways

March 2026 in “Molecules”

Camellia sinensis seed flavonoids can reduce skin inflammation and damage from UV rays.

Dual Deficiency of Melatonin and Dihydrotestosterone Promotes Stromal Cell Damage and Mediates Prostatitis via the cGAS-STING Pathway in Sleep-Deprived Mice

research Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

March 2024 in “Cell communication and signaling”

Lack of sleep in mice leads to prostatitis by reducing certain hormones and activating an inflammatory pathway, which can be temporarily fixed with normal sleep.

research 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment

April 2017 in “Journal of Investigative Dermatology”

SM04755 may be an effective topical treatment for psoriasis.

research The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases

70 citations , October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

research Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway.

24 citations , June 2018 in “PubMed”

Serenoa repens extract helps regrow hair and repair hair loss by activating certain cell growth pathways.

research Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

6 citations , January 2023 in “International journal of molecular sciences”

Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.

research Fruit Acid Inhibits UV-Induced Skin Aging via PI3K/Akt and NF-κB Pathway Inhibition

3 citations , January 2025 in “Discovery Medicine”

Fruit acids can help prevent skin aging from UV exposure.

A Novel Cell-Penetrating Peptide Supports Hair Follicle Growth Through Anti-Inflammatory and Growth Factor-Associated Mechanisms in Preclinical Models

research A novel cell-penetrating peptide supports hair follicle growth through anti-inflammatory and growth factor–associated mechanisms in preclinical models

April 2026 in “BMC Biotechnology”

A new peptide, DualPep-ALO, may help hair growth by reducing inflammation and boosting growth factors.

research Protective effect of a novel metal-phenolic network composite against ultraviolet-induced skin damage by modulating MAPK/AP-1/NF-κB signaling pathways and attenuating oxidative stress in human keratinocytes

December 2025 in “Biomedicine & Pharmacotherapy”

Melamax® protects skin from UV damage and reduces inflammation and oxidative stress.