15 citations
,
October 2011 in “Gynecological Endocrinology” Obesity changes androgen levels in women with PCOS, leading to higher testosterone relative to androstenedione.
202 citations
,
January 1989 in “Journal of Clinical Investigation” Insulin changes sex hormone levels in women with polycystic ovary syndrome without affecting other hormone releases.
91 citations
,
November 2007 in “European journal of endocrinology” Metformin helps with PCOS symptoms no matter the patient's initial insulin resistance or weight.
43 citations
,
January 1999 in “Endocrinology” Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.
29 citations
,
March 2010 in “Journal of Endocrinological Investigation” Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.
23 citations
,
March 1994 in “Fertility and sterility” Most patients improved with oral contraceptives, but some needed additional treatment.
12 citations
,
January 2016 in “Journal of Assisted Reproduction and Genetics” Certain gene variations are linked to higher male hormone levels in Chinese women with PCOS and insulin resistance.
8 citations
,
March 2022 in “International Journal of Endocrinology” Combining spironolactone with metformin reduces insulin resistance in PCOS better than either drug alone.
7 citations
,
January 2015 in “Case reports in endocrinology” The document concludes that HAIR-AN syndrome should be considered when a patient shows severe hyperandrogenism and insulin resistance after excluding tumors.
7 citations
,
October 2024 in “Livers” Sex hormones affect liver fat and metabolic health differently in men and women.
7 citations
,
January 2022 in “Case Reports in Endocrinology” Ovarian hyperthecosis can cause symptoms even with normal testosterone levels, and surgery can improve these symptoms.
5 citations
,
October 2018 in “Journal of Clinical Laboratory Analysis” Women with PCOS who have high male hormone levels often also have insulin resistance.
4 citations
,
June 2021 in “Applied Sciences” Women with PCOS have higher body fat and worse insulin resistance and lipid profiles.
2 citations
,
July 2024 in “Ibn AL- Haitham Journal For Pure and Applied Science” PCOS women with COVID-19 have higher cardiometabolic risks.
2 citations
,
July 2012 in “Journal of Pediatric and Adolescent Gynecology” A 12-year-old girl with very high testosterone and insulin resistance improved with birth control pills, suggesting PCOS can cause high testosterone without tumors.
December 2024 in “American Journal of Case Reports” Underweight women with PCOS can have insulin resistance, and treatment with metformin and dexamethasone can improve symptoms.
April 2019 in “Journal of the Endocrine Society” A young patient with unusual insulin resistance and high testosterone levels had a rare INSR gene mutation.
January 2015 in “International Journal of Research in Medical Sciences” A patient with HAIR-AN syndrome, PCOS, and Hashimoto's thyroiditis improved with early diagnosis and treatment to prevent serious health problems.
February 2026 in “World Journal of Interdisciplinary Innovation Sciences” Cinnamon may help improve insulin sensitivity in women with PCOS.
April 2019 in “Journal of the Endocrine Society” Androgens and estrogens are crucial for insulin secretion in males.
January 2016 in “Indian journal of clinical and experimental dermatology” Early hair loss in young males may not be clearly linked to insulin resistance or metabolic syndrome.
6 citations
,
April 2016 in “Journal of the Formosan Medical Association” Metformin improved insulin resistance and BMI in overweight Taiwanese women with PCOS, and a 2-hour insulin test may be a good screening tool.
7 citations
,
May 2007 in “PubMed” Women with androgenetic alopecia (AGA) are more insulin resistant than healthy women, with various insulin sensitivity indices being higher in the AGA group. An oral glucose tolerance test is suggested for women with AGA.
1 citations
,
September 2024 in “Journal of Clinical & Translational Endocrinology” PCOS women have more severe metabolic issues and higher androgen levels than hyperandrogenic women without PCOS.
January 2019 in “Current research in diabetes & obesity journal” A woman with type 2 diabetes developed alopecia areata, suggesting a link between the two autoimmune conditions.
February 2022 in “Mediators of Inflammation” Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.
November 2024 in “Journal of Investigative Dermatology” Ursolic and shikimic acid together boost hair growth better than alone.
65 citations
,
December 1986 in “The Journal of Clinical Endocrinology & Metabolism” The woman had a genetic condition causing high cortisol and androgen levels, treatable with dexamethasone.
3 citations
,
August 2020 in “Nutrition Journal” Spinach-derived thylakoid supplements plus a low-calorie diet helped obese women with polycystic ovary syndrome lose weight and improve their metabolism.
1 citations
,
January 2001 in “Drug and therapeutics bulletin” The document concludes that management strategies for PCOS are important due to its common occurrence and associated health risks.