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research Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles

28 citations , November 2012 in “Experimental dermatology”

A protein complex called mTORC1 likely affects when hair growth starts in mice.

research mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration

71 citations , January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

research 518 Nutrient and stress sensing as novel physiological regulator of human hair pigmentation and greying: Role of mTORC1 activity

November 2022 in “Journal of Investigative Dermatology”

Blocking mTORC1 activity could increase hair pigmentation and potentially reverse greying.

research 650 Controlling mTORC1 activity as a novel therapeutic strategy for managing human hair growth and pigmentation

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking mTORC1 activity with rapamycin could help increase hair pigmentation and growth, potentially reversing gray hair.

Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

research Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

12 citations , February 2014 in “PLoS ONE”

Topical rapamycin may effectively treat fibrous papules on the face.

research 3D bioprinting of calcium molybdate nanoparticles-containing immunomodulatory bioinks for hair regrowth

3 citations , June 2023 in “Nano today”

A special bioink with nanoparticles helps regrow hair by reducing inflammation and promoting hair growth signals.

research Signaling from keratins

May 2006 in “The Journal of Cell Biology”

Keratin 17 is crucial for cell growth in wound healing by aiding protein synthesis.

ATP-Competitive mTOR Kinase Inhibitors Delay Plant Growth by Triggering Early Differentiation of Meristematic Cells Without Developmental Patterning Change

research ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change

161 citations , August 2013 in “Journal of experimental botany”

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

research Frontal fibrosing alopecia: A review of disease pathogenesis

2 citations , July 2022 in “Frontiers in Medicine”

The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.

research The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling

35 citations , July 2022 in “Frontiers in Cell and Developmental Biology”

Proper mTOR signaling is crucial for healthy skin and preventing skin diseases.

research Birt–Hogg–Dubé syndrome

7 citations , September 2013 in “Familial cancer”

Birt–Hogg–Dubé syndrome is a rare genetic condition causing skin lesions, lung cysts, and a higher chance of kidney cancer.

research The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

177 citations , March 2018 in “International Journal of Molecular Sciences”

mTOR inhibitors may help treat lung fibrosis.

Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury

research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury

6 citations , February 2022 in “The journal of neuroscience/The Journal of neuroscience”

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.

research 0843 N6-methyladenosine RNA modification promotes keratinocyte proliferation and cutaneous wound repair through regulation of MTOR stability

1 citations , July 2025 in “Journal of Investigative Dermatology”

Increasing m6A levels can improve skin cell growth and wound healing.

research Enhanced Insights into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies

1 citations , May 2024 in “Dermatology and Therapy”

Frontal Fibrosing Alopecia needs better diagnostics and treatments, with dutasteride showing promise.

research CAQ Corner: Basic concepts of transplant immunology

May 2022 in “Liver transplantation”

The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.

research Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis

36 citations , March 2011 in “Nature Communications”

Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.

research A symphony of signals: the intricate role of lncRNAs in dermatological disorders

1 citations , November 2025 in “Clinical and Experimental Medicine”

lncRNAs are important for understanding and treating skin diseases.

Issue Information - Table of Contents: April 2016 Journal of the European Academy of Dermatology and Venereology

research Issue Information - TOC

March 2016 in “Journal of the European Academy of Dermatology and Venereology”

The April 2016 JEADV issue covered various dermatology topics, including psoriasis, psoriatic arthritis, mTOR inhibitors, autoimmune diseases, photodynamic therapy, viral DNA in skin diseases, chronic hand eczema, and female hair loss.

Catalytic-Dependent and -Independent Activities of Polycomb Repressive Complex 1 Differentially Regulate Skin Stem Cell Specification

research 864 Catalytic-dependent and -independent activities of Polycomb repressive complex 1 differentially regulate skin stem cell specification

April 2017 in “Journal of Investigative Dermatology”

PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.

research Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities

June 2026 in “Frontiers in Immunology”

Tissue remodeling involves structural and functional changes in organs, regulated by complex signaling networks. Canonical pathways like the TGF-β superfamily, growth factors, and the MMPs/TIMPs system are crucial for extracellular matrix turnover and fibroblast activation, influencing the inflammatory microenvironment. Recent insights reveal the importance of mechanical signals via the integrin-YAP/TAZ axis and metabolic reprogramming through the glycolysis-HIF-mTOR axis, which provide energy for cell activation. Non-coding RNAs also play a significant role in refining these processes. This review integrates both traditional and new mechanisms to identify shared principles of pathological remodeling across organs, aiming to support the development of precision therapeutic strategies.

Cell Surface Receptor Kinase FERONIA Linked to Nutrient Sensor TORC Signaling Controls Root Hair Growth at Low Temperature Linked to Low Nitrate in Arabidopsis Thaliana

research Cell surface receptor kinase FERONIA linked to nutrient sensor TORC signaling controls root hair growth at low temperature linked to low nitrate inArabidopsis thaliana

2 citations , January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called FERONIA helps control root hair growth in response to cold and low nitrogen by activating nutrient-sensing pathways in a plant called Arabidopsis.

research 1341 Possible role of mTOR signaling pathway in radiation dermatitis

April 2023 in “Journal of Investigative Dermatology”

The mTOR signaling pathway might play a role in radiation dermatitis, but more research is needed.

research Patients with bullous skin disease in a high‐epidemic COVID‐19 area, Bergamo, Italy

17 citations , June 2020 in “British Journal of Dermatology”

Oral mTOR inhibitors often cause skin and hair side effects but usually don't require stopping treatment.

Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

93 citations , January 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

research Androgen receptor: A promising therapeutic target in breast cancer

21 citations , March 2019 in “Critical Reviews in Clinical Laboratory Sciences”

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat

19 citations , October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.