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Did you mean Cardiac Hypertrophy?

GlossaryCardiac Hypertrophy

thickening of heart muscle due to increased workload

Cardiac Hypertrophy, also known as Myocardial Hypertrophy, is the thickening of the heart muscle, specifically the myocardium. This condition can result from increased workload on the heart due to high blood pressure or other cardiovascular diseases, leading to an enlarged heart that may struggle to pump blood efficiently. While it can be a compensatory response to increased demand, prolonged hypertrophy can lead to heart failure and other complications.

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Serum Dihydrotestosterone Levels Are Associated With Adverse Myocardial Remodeling in Patients With Severe Aortic Valve Stenosis Before and After Aortic Valve Replacement

research Serum dihydrotestosterone levels are associated with adverse myocardial remodeling in patients with severe aortic valve stenosis before and after aortic valve replacement

4 citations , October 2022 in “American journal of physiology. Heart and circulatory physiology”

Higher DHT levels are linked to worse heart changes in severe aortic valve stenosis patients.

research Sex Hormones and Related Compounds, Including Hormonal Contraceptives

January 2015 in “Side effects of drugs annual”

The document concludes that sex hormones and related compounds have various effects on health, with both potential benefits and risks.

research Anabolic-androgenic steroids and cardiovascular risk

38 citations , September 2019 in “Chinese Medical Journal”

Using steroids can increase the risk of heart problems.

research Forensic approach in cases of anabolic-androgenic steroid abuse and cardiovascular mortality: insights from autopsy, histopathology, immunohistochemistry and toxicology

1 citations , October 2025 in “Frontiers in Cardiovascular Medicine”

Anabolic-androgenic steroid abuse can cause heart damage and sudden death.

research Targeting cardiac hypertrophy through a nuclear co‐repressor

3 citations , October 2019 in “EMBO molecular medicine”

Targeting NCoR1 can help treat heart enlargement and dysfunction.

research Gender Differences in Cardiac Hypertrophy

27 citations , February 2020 in “Journal of Cardiovascular Translational Research”

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice

research Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice

13 citations , August 2018 in “Journal of Molecular and Cellular Cardiology”

Finasteride improves heart function and repairs damage after heart attack in mice.

Anabolic Androgenic Steroids Impact on Cardiovascular Risk and Events: A Literature Review

research Anabolic androgenic steroids impact on cardiovascular risk and cardiovascular events. The literature review

April 2026 in “Quality in Sport”

Anabolic-androgenic steroids increase the risk of heart problems.

research Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

61 citations , April 2023 in “Bioactive Materials”

Microneedles are effective for painless drug delivery and promoting wound healing and tissue regeneration.

research Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction

56 citations , January 2015 in “Circulation”

Finasteride helps reduce heart issues and improves heart function.

Maternal Androgen Excess Inhibits Fetal Cardiomyocyte Proliferation Through RB-Mediated Cell Cycle Arrest and Induces Cardiac Hypertrophy in Adulthood

research Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood

2 citations , August 2023 in “Journal of Endocrinological Investigation”

Excess maternal androgens can cause heart problems in offspring.

research Myocardial NF-κB activation is essential for zebrafish heart regeneration

85 citations , October 2015 in “Proceedings of the National Academy of Sciences of the United States of America”

NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

research Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring

21 citations , July 2019 in “Cardiovascular Research”

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

research WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

36 citations , June 2021 in “Experimental & Molecular Medicine”

Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.

research Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids

305 citations , March 2018 in “International journal of molecular sciences”

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

research A nude mouse model of hypertrophic scar shows morphologic and histologic characteristics of human hypertrophic scar

47 citations , November 2012 in “Wound repair and regeneration”

Nude mice with grafted human skin developed scars similar to human hypertrophic scars.

research Comparative Study of Myocardial Biomarkers Among Women with and Without Polycystic Ovarian Syndrome (Pcos) in Nigeria

December 2025 in “International journal of research and scientific innovation”

Women with PCOS in Nigeria have higher heart risk markers, needing early heart health checks.

Left Ventricular Myocardial Mass Index and Its Correlates as an Early Marker of Cardiovascular Risk Among Nonobese Normotensive Indian Women With Polycystic Ovary Syndrome: Lessons From a Cross-Sectional Study

research Left ventricular myocardial mass index and its correlates as an early marker of cardiovascular risk among nonobese normotensive Indian women with polycystic ovary syndrome: lessons from a cross-sectional study

May 2020 in “Fertility and Sterility”

Nonobese, normotensive Indian women with PCOS may have a higher risk of heart problems linked to inflammation and insulin resistance.

Cedrol Mitigates Hepatic Lipid Accumulation and Adipocyte Hypertrophy Induced by Corticosteroids Through the Inhibition of Glucocorticoid Receptor Activity

research Cedrol mitigates hepatic lipid accumulation and adipocyte hypertrophy induced by corticosteroids through the inhibition of glucocorticoid receptor activity

December 2025 in “Scientific Reports”

Cedrol may help reduce liver fat and fat cell growth caused by corticosteroids.

research Ion Sequential Therapy Aligned With Pathological Changes Enhances Cardiac Function After Myocardial Infarction

September 2024

Ion sequential therapy improves heart function after a heart attack.

research Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction

40 citations , November 2021 in “npj Regenerative Medicine”

Adult spiny mice recover better from heart attacks than common lab mice.

Effects of Chronic Inhibition of Testosterone Metabolism on Cardiac Remodeling After Ischemia/Reperfusion-Induced Myocardial Damage in Gonadectomized Rats

research Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats

4 citations , May 2019 in “Biology open”

Testosterone reduces heart damage and inflammation after injury.

research Finasteride as a potential tool to improve Mesenchymal stem cell transplantation for myocardial infarction

4 citations , January 2012 in “Medical Hypotheses”

Finasteride may improve stem cell therapy for heart attacks by increasing cell survival.

research Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice

18 citations , April 2013 in “PLOS ONE”

Mice with autoimmune hair loss showed signs of heart problems.

research Epicardial Fat Thickness in Children with Classic Congenital Adrenal Hyperplasia

9 citations , February 2019 in “Journal of Clinical Research in Pediatric Endocrinology”

Children with classic congenital adrenal hyperplasia have thicker heart fat and are at higher risk for heart problems and early atherosclerosis.

research Anabolic-androgenic steroids. Mechanism of action and clinical effects

1 citations , September 2023 in “Journal of Education Health and Sport”

Anabolic-androgenic steroids are dangerous and educating people about their risks is essential.

Benefits of Multi-Pass Laser Skin Rejuvenation Treatments

research Literature Reviews

December 2008 in “The American Journal of Cosmetic Surgery”

Multi-pass laser skin treatments improved healing, reduced pain, and had no major complications.

The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia

research The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia

6 citations , May 2020 in “Pharmacology Research & Perspectives”

A new gel form of minoxidil is equally effective for hair growth and safer for the heart and other organs than the traditional solution.

research Abstract 153: Inhibition of the 5-a-reductase Reduces Cardiac Hypertrophy and Improves Cardiac Function

August 2013 in “Circulation Research”

Finasteride reduces heart enlargement and improves heart function.

Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the ESC Working Group on Cellular Biology of the Heart

research Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

47 citations , May 2020 in “Cardiovascular Research”

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.