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GlossaryNeuropeptides

small protein-like molecules that neurons use to communicate

Neuropeptides are small protein-like molecules used by neurons to communicate with each other. They influence a variety of brain functions, including pain perception, reward, food intake, metabolism, reproduction, social behaviors, and learning. In the context of hair and alopecia, neuropeptides can affect hair growth by modulating the activity of hair follicle cells and influencing the local immune response.

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research Modulation of neuropeptide Y and Y₁ receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y₁R/LacZ transgenic mice

15 citations , November 2007 in “Journal of Neurochemistry”

Stopping alcohol after long-term use causes anxiety and changes brain chemicals.

research Changes in expression of the neuropeptide Y Y₁ receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery

12 citations , September 2002 in “Journal of Neurochemistry”

Pregnancy-related hormone changes affect Y1 receptor gene expression in mice.

Restoring Neuropeptide Y Levels In The Hypothalamus Ameliorates Premature Aging Phenotype In Mice

research Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

4 citations , February 2025 in “GeroScience”

Increasing neuropeptide Y in the brain can slow aging signs in mice.

Recent Advances in Neuropeptide-Related Omics and Gene Editing: Spotlight on NPY and Somatostatin and Their Roles in Growth and Food Intake of Fish

research Recent advances in neuropeptide-related omics and gene editing: Spotlight on NPY and somatostatin and their roles in growth and food intake of fish

October 2022 in “Frontiers in Endocrinology”

New tools show that in fish, NPY increases feeding and somatostatin decreases it.

research Neuropeptídeos na pele

27 citations , August 2003 in “Anais Brasileiros de Dermatologia”

Neuropeptides affect skin inflammation, repair, and hair growth, with potential for therapy.

research Hair-Cycle-Associated Remodeling of the Peptidergic Innervation of Murine Skin, and Hair Growth Modulation by Neuropeptides

112 citations , February 2001 in “Journal of Investigative Dermatology”

Neuropeptides affect hair growth, with some speeding it up and others slowing it down.

Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

research [Implication of VEGF, steroid hormones and neuropeptides in hair follicle cell responses].

12 citations , May 2002 in “PubMed”

Hair growth is regulated by a combination of hormones, blood vessels, and nerve signals.

research Regulation of human hair growth: hormones and neuropeptides

January 2016 in “프로그램북(구 초록집)”

Hormones and neuropeptides affect hair growth, with androgens having opposite effects on beard and scalp hair.

research Increased expression of the gene for the Y₁ receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y₁R/LacZ transgenic mice in response to restraint stress

22 citations , April 2004 in “Journal of Neurochemistry”

Acute stress increases Y1 receptor gene expression in certain brain areas, but repeated stress does not.

research Lymphocytes, neuropeptides, and genes involved in alopecia areata

286 citations , August 2007 in “Journal of Clinical Investigation”

Alopecia areata is an autoimmune disease where T cells attack hair follicles.

research Hair(y) Matters in Melanoma Biology

7 citations , May 2020 in “Trends in molecular medicine”

The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.

research Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors

57 citations , May 2014 in “Molecular Phylogenetics and Evolution”

The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.

research Saliva secretion in engrafted mouse bioengineered salivary glands using taste stimulation

10 citations , January 2014 in “Journal of prosthodontic research”

Bioengineered salivary glands in mice can produce saliva when tasting sour or bitter, but have different protein levels and nerve signals compared to natural glands.

research [Peptidergic innervation in the sinus hair follicles of several mammalian species].

7 citations , October 1992 in “PubMed”

Sinus hair follicles in mammals have different nerve fiber types with species-specific patterns, especially in cats.

research Effects of SM-215 on Hair Growth by Hair Follicle Stimulation

2 citations , October 2015 in “Indian journal of science and technology”

SM-215 promotes hair growth by improving the environment around hair follicles.

research Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair

1 citations , April 2025 in “Pigment Cell & Melanoma Research”

Managing stress and nerve activity can help treat segmental vitiligo and white hair.

research The itchy scalp - scratching for an explanation

61 citations , October 2011 in “Experimental dermatology”

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

research Single cell deciphering of pruritic keloids: the interaction between fibroblasts and Schwann cells through the Midkine signaling

1 citations , January 2025 in “Burns & Trauma”

Targeting Midkine can help reduce pain and itching in keloids.

research The brain–gut–skin axis in inflammatory and disfiguring skin diseases: mechanistic insights, clinical correlations, and therapeutic strategies

February 2026 in “Frontiers in Immunology”

Skin diseases like acne and psoriasis are linked to stress, gut health, and inflammation, with new treatments focusing on gut and mind-body approaches.

Gene Polymorphisms and Serum Levels of BDNF and CRH in Vitiligo Patients

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations , August 2004 in “Journal of Investigative Dermatology”

Hair loss causes stress and affects mental health; treatment and support needed.