5 citations
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March 2019 in “Scientific Reports” The technique can isolate cells to help treat skin pigmentation issues.
November 2022 in “Journal of Investigative Dermatology” Dynlt3 is important for melanosome transport and skin coloration.
93 citations
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October 2006 in “The International Journal of Biochemistry & Cell Biology” Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.
June 2025 in “Cell Regeneration” Lack of a certain enzyme causes hair to grey early by damaging stem cells, but an antioxidant can help prevent this.
August 2024 in “Animal Bioscience” Exosomal miR-222-3p reduces melanin production in rabbits by targeting the SOX10 gene.
June 2021 in “Asian Journal of Medical Sciences” Vitamin B12 deficiency can cause reversible skin darkening.
6 citations
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April 2019 in “Pesquisa Veterinária Brasileira” Milk can carry harmful plant toxins that pose health risks to animals and humans.
November 2025 in “Zenodo (CERN European Organization for Nuclear Research)” Oxidative dyes damage hair more than semi-permanent dyes, but new technologies help protect hair while coloring.
3 citations
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August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.
30 citations
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June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” Oral zinc sulphate reduces dark hair color in mice.
June 2023 in “International Journal of Dermatology” Lichen planus pigmentosus mainly affects middle-aged women with darker skin, is underreported, and is hard to treat.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Scientists discovered a new way UVB light increases skin pigmentation through the ATP-P2X7 pathway.
August 2013 in “Toxicology letters” 6 citations
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September 2010 in “Pigment Cell & Melanoma Research” We know less about human hair pigmentation than mouse coat color, but pH and cysteine levels are key factors.
17 citations
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April 2002 in “Contact Dermatitis” Minoxidil 5% caused skin discoloration in a man using it for hair loss.
210 citations
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May 2006 in “The FASEB journal” Oxidative stress causes hair to gray by damaging and killing pigment cells.
27 citations
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February 2003 in “Cell and Tissue Research” FM dyes effectively stain Merkel cells for long-term observation.
7 citations
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January 1992 in “Skin Pharmacology and Physiology” Minoxidil binds to hair pigment but doesn't affect hair growth.
March 2007 in “The FASEB Journal” Henna mixed with PPD can cause skin reactions, scarring, and a specific type of baldness, and needs more research to understand these effects.
12 citations
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December 1962 in “Journal of Investigative Dermatology”
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” A new staining method shows a special area in the hair's skin layer with lots of proteoglycans.
7 citations
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October 1985 in “Genetics Research” Beige and leaden pigment genes act within melanocytes, affecting pigment patterns.
20 citations
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October 2001 in “British Journal of Ophthalmology” A patient with congenital erythropoietic porphyria showed eye issues due to porphyrin buildup.
November 2022 in “Skin Appendage Disorders” PT-20 did not significantly improve gray hair repigmentation.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” The herbal mehendi gel safely colors hair and nourishes the scalp.
November 2022 in “Journal of Investigative Dermatology” Apocynin may protect skin cells from aging and damage caused by UVB light.
29 citations
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January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
7 citations
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September 2024 in “Journal of Microbiology and Biotechnology” Peperomia pellucida is safe to eat and has strong antioxidant benefits.
May 2026 in “International Journal of Molecular Sciences” The new human placental extract may help prevent hair graying and reduce nerve pain from chemotherapy.
4-(Ethoxycarbophenyl) retinamide is much less toxic than other retinoids.