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GlossaryOCT4

protein crucial for maintaining embryonic stem cell pluripotency

OCT4, also known as Octamer-binding transcription factor 4 or POU5F1, is a protein that plays a crucial role in maintaining the self-renewal and pluripotency of embryonic stem cells. It acts as a transcription factor, meaning it helps regulate the expression of genes that are essential for the development and differentiation of cells. This protein is significant in both developmental biology and regenerative medicine, as it helps scientists understand how cells can be reprogrammed to an undifferentiated state.

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research OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

57 citations , January 2019 in “Stem Cell Research & Therapy”

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

research Transdifferentiation of Human Hair Follicle Mesenchymal Stem Cells into Red Blood Cells by OCT4

15 citations , January 2015 in “Stem cells international”

Human hair follicle stem cells can be turned into red blood cells.

Role of OCT4 in the Regulation of FSH-Induced Granulosa Cell Growth in Female Mice

research Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice

14 citations , January 2020 in “Frontiers in Endocrinology”

OCT4 helps granulosa cell growth in early-stage follicles, and FSH increases OCT4 through specific pathways.

ZO-1 Boosts the In Vitro Self-Renewal of Pre-Haematopoietic Stem Cells from OCT4-Reprogrammed Human Hair Follicle Mesenchymal Stem Cells Through Cytoskeleton Remodeling

research ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling

December 2024 in “Stem Cell Research & Therapy”

ZO-1 helps hair follicle stem cells renew better by changing their structure.

research Dauricine attenuates Oct4/sonic hedgehog co‐activated stemness and induces reactive oxygen species‐mediated mitochondrial apoptosis via AKT/β‐catenin signaling in human neuroblastoma and glioblastoma stem‐like cells

5 citations , October 2023 in “Phytotherapy Research”

Dauricine may help treat certain brain cancers by reducing cancer cell growth and promoting cell death.

research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

344 citations , June 2006 in “American Journal Of Pathology”

Human hair follicles can provide stem cells for regenerative medicine.

research Human dermal stem cells differentiate into functional epidermal melanocytes

164 citations , February 2010 in “Journal of Cell Science”

Human dermal stem cells can become functional skin pigment cells.

Cartilage to Bone Transformation During Fracture Healing Is Coordinated by the Invading Vasculature and Induction of the Core Pluripotency Genes

research Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes

160 citations , January 2017 in “Development”

Blood vessels and specific genes help turn cartilage into bone when bones heal.

research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2

123 citations , November 2012 in “Stem cells”

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

research Induced Pluripotent Stem Cells from Human Hair Follicle Mesenchymal Stem Cells

64 citations , December 2012 in “Stem Cell Reviews and Reports”

Human hair follicle cells can be turned into stem cells similar to embryonic stem cells.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning

18 citations , November 2016 in “PeerJ”

Human hair follicles can be used to create stem cells that might help clone hair for treating hair loss or helping burn patients.

research Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/β‐catenin signaling

16 citations , July 2014 in “Cell Biology International”

Lithium chloride helps hair follicle cells become tooth cells by activating a specific signaling pathway.

research Tanshinone IIA pretreatment protects free flaps against hypoxic injury by upregulating stem cell-related biomarkers in epithelial skin cells

13 citations , September 2014 in “BMC Complementary and Alternative Medicine”

Tanshinone IIA helps protect skin tissue from low oxygen damage by boosting certain cell markers.

research Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway

11 citations , June 2021 in “Frontiers in Cell and Developmental Biology”

Melatonin helps goat hair stem cells grow and maintain their ability to become different cell types.

research RETRACTED: Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers

6 citations , October 2014 in “International Journal of Molecular Sciences”

Tanshinone IIA helps protect tissue from low oxygen damage by activating certain cell pathways.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

research In vitro identification of a stem cell population from canine hair follicle bulge region

5 citations , December 2017 in “Tissue and cell/Tissue & cell”

Researchers found stem cells in dog hair follicles using specific markers.

research Establishment and molecular characterization of human dermal mesenchymal-like stem cells derived from human scalp biopsy of androgenetic alopecia patient

4 citations , January 2013 in “Stem cell discovery”

Researchers created a cell line from a hair follicle to study hair loss.

Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion

research Development and Molecular Characterization of Human Placental Mesenchymal Stem Cells from Human Aborted Fetal Tissue as a Model to Study Mechanism of Spontaneous Abortion

3 citations , February 2014 in “Advances in Stem Cells”

Placenta-derived stem cells can help study and treat spontaneous abortion.

The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-Aging Therapy

research The Role of Box A ofHMGB1in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy

1 citations , January 2023 in “In vivo/In Vivo”

Box A of HMGB1 can improve stem cell function, aiding anti-aging therapy.

research In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using Ficus religiosa L. and Morus alba L.

1 citations , February 2021 in “Journal of Natural Remedies”

Ficus religiosa and Morus alba extracts improved hair growth and follicle regeneration in mice.

Retainability of Pluripotency and Viability of Multilineage-Differentiating Stress Enduring (Muse) Cells After Repeated Cryopreservation

research LB1606 Retainability of pluripotency and viability of multilineage-differentiating stress enduring (Muse) cells after repeated cryopreservation.

1 citations , August 2018 in “Journal of Investigative Dermatology”

Muse cells keep their special features and can become different cell types even after being frozen and thawed three times.

Inhibition of the Hippo Pathway by Verteporfin Reduces the Proliferation and Stemness of Rat Hair Follicle Neural Crest Stem Cells Under Hypoxia

research Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia

February 2025 in “FASEB BioAdvances”

Verteporfin reduces growth and stem cell traits in rat hair follicle cells by blocking the Hippo pathway.

Exploration of Aloe Vera, Centella Asiatica, Green Tea, and Pueraria Mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through Beta-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells

research Exploration of Aloe vera, Centella asiatica, Green Tea, and Pueraria mirifica Extracts in Modulating Stem Cell-Like Properties for Hair Rejuvenation Through β-Catenin Stabilization and Activation of the Akt Signaling Cascade in Human Dermal Papilla Cells

February 2025 in “Natural Product Communications”

Aloe vera, Centella asiatica, Green Tea, and Pueraria mirifica extracts together boost hair growth by enhancing stem cell properties.

Induced Pluripotent Stem Cells from Human Hair Follicle Keratinocytes as a Potential Source for In Vitro Hair Follicle Cloning

research Peer Review #1 of "Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning (v0.1)"

November 2016

Human hair follicle cells can be turned into stem cells that may help clone hair for treating hair loss or burns.

research Rancangan televisyen: Menyangga atau menyanggah bahasa dan budaya?

December 2004 in “PLoS ONE”

The Foxn1(-/-) phenotype disrupts hair growth and affects skin stem cells.

The Effect of Glycyrrhizic Acid and Aqueous Licorice Extract on Hair Growth Retardation: In Vitro Mechanistic and Efficacy Studies in Human

research The effect of glycyrrhizic acid and aqueous licorice extract on hair growth retardation : in vitro mechanistic and efficacy studies in human

January 2016

Glycyrrhizic acid and licorice extract can significantly reduce unwanted hair growth.

research Glycyrrhizic acid attenuates stem cell-like phenotypes of human dermal papilla cells

21 citations , November 2015 in “Phytomedicine”

Glycyrrhizic acid may help reduce unwanted hair growth.

research Immunologic findings in central centrifugal cicatricial alopecia

1 citations , July 2012 in “Nasza Dermatologia Online”

CCCA may be caused by both hair traction and an immune response.