research Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds
The new wound dressing speeds up healing of infected wounds safely and effectively.
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330-360 / 1000+ resultsresearch Hydrogel microneedle delivery of a palmitoylated peptide promotes hair regeneration via dual activation of Wnt/β-catenin and cAMP–PKA signaling
The study developed a palmitoylated peptide, Pal-MPAPO, incorporated into a hyaluronic acid-based hydrogel microneedle system for effective transdermal delivery to promote hair regeneration. The microneedles demonstrated sufficient mechanical strength for skin insertion and enabled prolonged release of the peptide. In human dermal papilla cells, Pal-MPAPO activated the Wnt/β-catenin pathway and increased cAMP levels primarily through VPAC1, with no significant role for VPAC2. Molecular interactions were confirmed through various simulations and imaging techniques. In a C57BL/6 mouse model, the Pal-MPAPO-loaded microneedles significantly enhanced hair regrowth, showing similar efficacy to minoxidil but requiring less frequent application. This suggests Pal-MPAPO as a promising candidate for hair regeneration with the hydrogel microneedle system offering a targeted delivery method.
research Three-dimensional bioprinted hydrogels for the management of diabetic wounds: A review
3D bioprinted hydrogels could improve diabetic wound healing but face challenges like limited blood supply and scalability.
research Keratin hydrogels support the sustained release of bioactive ciprofloxacin
Keratin hydrogels can slowly release effective ciprofloxacin to prevent infections.
research FORMULATION AND EVALUATION OF PHYTO-HYDROGEL CONTAINING AZADIRACHTA INDICA AND TRIDAX PROCUMBENS FOR THE TREATMENT OF SEBORRHEIC DERMATITIS
The hydrogel with neem and tridax extracts effectively treats seborrheic dermatitis.
research Research Progress of Sodium Alginate-Based Hydrogels in Biomedical Engineering
Sodium alginate-based hydrogels are promising for medical use due to their versatility and biocompatibility.
research Silk fibroin nanofibers-GelMA hydrogel composite loaded with embryonic fibroblasts: A strategy for enhanced wound healing
The composite dressing improved wound healing and hair growth in mice.
research Effect of discarded keratin-based biocomposite hydrogels on the wound healing process in vivo
Keratin-based hydrogels from human hair improve wound healing effectively.
research 595 In vitro evaluation of skin distribution and human dermal papilla cells proliferation for minoxidil 5% topical lotion hydrogel
The new minoxidil hydrogel is a promising alternative for hair loss treatment, with similar effectiveness and less skin irritation.
research In vitro–in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis
The gel with apocynin-loaded nanoparticles shows promise for treating rheumatoid arthritis.
research Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases
Nanoemulgels could effectively treat skin diseases and may replace or complement current therapies.
research Exploring the Drug-Loading and Release Ability of FucoPol Hydrogel Membranes
FucoPol hydrogel membranes are promising for delivering drugs on the skin.
research Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure
The nanofiber scaffolds improved skin wound healing by supporting cell growth and tissue repair.
research Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels
Stiffness gradients in alginate gels can guide cancer cell invasion and study cellular behaviors.
research Freeze‐Drying Tumor Tissues Derived Bio‐Patches With Hair Melanin Nanoparticles Integration for Wound Healing
The bio-patch improves wound healing by reducing stress, inflammation, and promoting blood vessel growth.
research Pectin Nanoparticle-Loaded Soft Coral Nephthea sp. Extract as In Situ Gel Enhances Chronic Wound Healing: In Vitro, In Vivo, and In Silico Studies
The gel with coral extract and pectin nanoparticles helps heal chronic wounds.
research Design and initial characterization of fabricated composite scaffold dHPCTM-HPE (decellularized human placental connective tissue matrix - human placental extract)
The new composite scaffold may effectively treat chronic and deep wounds.
research Triple-layered core-shell fiber dressings with enduring platelet conservation and sustained growth factor release abilities for chronic wound healing
The new dressing improves chronic wound healing by preserving and releasing growth factors effectively.
research Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing
Dextran hydrogels improve burn wound healing and skin regeneration.
research Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment
New microneedle treatment with growth factors and a hair loss drug shows better and faster hair growth results than current treatments.
research Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment
Hydrogel microneedles offer a promising, minimally invasive way to treat diseases like cancer and hair loss, but need improvements in strength and standardization.
research Tri-layer gradient fibre-aligned electrospun composite: Accelerating skin wound healing
The dressing speeds up wound healing by mimicking skin's natural properties.
research Efficacy and safety of non‐cross‐linked hyaluronic acid compound in the treatment of keratosis pilaris: A split‐body randomized clinical trial
The non-cross-linked hyaluronic acid compound effectively and safely improves keratosis pilaris.
research Light‐Activatable Hyaluronic Acid‐Derivatives Releasing Nitric Oxide and Their Delivery in the Skin
Light-activated hyaluronic acid derivatives can enhance skin healing and regeneration.
research Formulation of Hair Gels Based on Mango Pectin and “Makoré” Butter
Gel D shows promise as a natural hair care solution for traction alopecia.
research Hydrocolloid Use in the Treatment of Thermal Injury in a Dog
Hydrocolloid dressings significantly improved healing of a dog's third-degree burn.
research Epidermal Stem Cells Manipulated by pDNA-VEGF165/CYD-PEI Nanoparticles Loaded Gelatin/β-TCP Matrix as a Therapeutic Agent and Gene Delivery Vehicle for Wound Healing
The gelatin/β-TCP scaffold with nanoparticles improves wound healing and skin regeneration.
research Treatment of a Spinal Cord Hemitransection Injury with Keratin Biomaterial Hydrogel Elicits Recovery and Tissue Repair
Keratin hydrogel from human hair helps rats recover better from spinal cord injuries.
research Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing
The new skin patch with human matrix and antibiotic improves wound healing.
research A New Primary Wound Dressing Made of Polyethylene Oxide Gel
Vigilon, a new wound dressing, promotes faster and better healing with less pain.