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GlossaryPI3K inhibitor

blocks enzyme activity involved in cell growth and survival

A PI3K inhibitor, also known as a phosphoinositide 3-kinase inhibitor, is a type of drug that blocks the activity of the PI3K enzyme. This enzyme is involved in various cellular functions, including growth, proliferation, and survival. By inhibiting PI3K, these drugs can help treat certain cancers and other diseases where PI3K is abnormally active.

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Stimulation by Exosomes from Hypoxia-Preconditioned Hair Follicle Mesenchymal Stem Cells Facilitates Mitophagy by Inhibiting the PI3K/AKT/mTOR Signaling Pathway to Alleviate Ulcerative Colitis

research Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis

January 2024 in “Theranostics”

Exosomes from special stem cells help treat ulcerative colitis by reducing inflammation and stress.

research Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling

12 citations , November 2024 in “International Journal of Molecular Sciences”

Hydroxytyrosol helps reduce liver injury by blocking certain inflammation pathways.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations , January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

research Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis

8 citations , July 2024 in “Journal of Advanced Research”

CDK inhibitors may help treat ARDS and psoriasis but need more testing for safety and effectiveness.

research Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats

28 citations , May 2018 in “Scientific reports”

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

20 citations , November 2020 in “Stem Cell Research & Therapy”

Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.

Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

June 2020

Enhanced stem cells from the placenta can reduce fat cell formation in eye disease.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

September 2020 in “Research Square (Research Square)”

Enhanced stem cells from the placenta can reduce fat buildup in eye tissue for Graves' disease.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

August 2020 in “Research Square (Research Square)”

Enhanced stem cells can reduce fat buildup in eye tissue for Graves' disease.

research EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals

53 citations , January 2012 in “Developmental Biology”

EGFR signaling is essential for ear cell regeneration in both birds and mammals.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique

1 citations , January 2024 in “NPJ breast cancer”

Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.

research NF-κB in biology and targeted therapy: new insights and translational implications

1 citations , March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

research An overview of animal models induced by glucocorticoids

September 2023 in “Physiology and Pharmacology”

Glucocorticoids can cause various health issues, but some treatments may help reduce these effects.

research The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19

15 citations , July 2022 in “Frontiers in Pharmacology”

Cepharanthine may help treat COVID-19 by targeting similar pathways as other inflammatory diseases.

research Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives

9 citations , August 2024 in “International Journal of Molecular Sciences”

Promising treatments for EBS include anti-inflammatory drugs, antibiotics, creams, mTOR inhibitors, and gene editing, but more trials are needed.

research 691 Topical curcumin promotes induction of the murine hair cycle

3 citations , April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Curcumin applied to the skin can start hair growth in mice.

research New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics

August 2023 in “Frontiers in Oncology”

New drugs and therapies targeting specific pathways show promise in treating advanced prostate cancer.

research Activation of AR Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

23 citations , December 2013 in “Molecular cancer therapeutics”

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

research Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

7 citations , August 2022 in “Experimental dermatology”

Blocking YAP/TAZ could be a new way to treat skin cancer.

research Cutaneous adverse effects of targeted therapies

149 citations , January 2015 in “Journal of the American Academy of Dermatology”

Targeted cancer therapies often cause skin side effects, needing dermatologist care.

research Finasteride as a potential tool to improve Mesenchymal stem cell transplantation for myocardial infarction

4 citations , January 2012 in “Medical Hypotheses”

Finasteride may improve stem cell therapy for heart attacks by increasing cell survival.

research Role of phosphatidylinositol 3‐kinase signaling pathway in radiation‐induced liver injury

6 citations , July 2020 in “The Kaohsiung Journal of Medical Sciences”

Inhibiting the PI3K/Akt pathway may help prevent radiation-induced liver injury.

research Bioassay-guided isolation of two antiproliferative metabolites from Pterocarpus indicus Willd. against TGF-β-induced prostate stromal cells (WPMY-1) proliferation via PI3K/AKT signaling pathway

3 citations , October 2024 in “Frontiers in Pharmacology”

Compounds from Pterocarpus indicus may help treat benign prostatic hyperplasia by stopping cell growth.

Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model

research Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model

February 2022 in “Journal of Biomedical Nanotechnology”

Shikonin, a small molecule, speeds up burn wound healing and hair growth by activating the PI3K/Akt pathway.

research Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways

May 2024 in “Biochemical pharmacology”

Blocking CISD1 reduces hearing loss from cisplatin in mice.

research The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation

15 citations , March 2015 in “Experimental Dermatology”

Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.

research Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway

9 citations , September 2024 in “Scientific Reports”

Cardamonin may help treat oral cancer by promoting cell death and stopping cancer cell growth.

research The Acne-treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil in Vitro and in Vivo

August 2021 in “Research Square (Research Square)”

Borneol Essential Oil could be a natural and safe acne treatment.

research Evaluation of Cacumen Platycladi Extract for Hair Loss Prevention: Mechanisms, Efficacy, and Clinical Application

January 2026 in “Cosmetics”

Cacumen Platycladi extract can safely and effectively reduce hair loss and increase hair density.