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research Synthesis and Evaluation of 2‘-Substituted 4-(4‘-Carboxy- or 4‘-carboxymethylbenzylidene)-N-acylpiperidines: Highly Potent and in Vivo Active Steroid 5α-Reductase Type 2 Inhibitors

22 citations , June 2002 in “Journal of Medicinal Chemistry”

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

research Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones

December 2016

The research created new azasteroids and pseudoazulenyl nitrones, which could be useful in medicine.

research Synthesis and anticancer activity evaluation of Novel 6 mercaptopurine derivatives.

January 2015 in “Journals & Books Hosting (International Knowledge Sharing Platform)”

Compound 1 showed promising anticancer activity.

Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

Compound 15a was effective in inhibiting 5α-reductase.

research Estudio de la reactividad de los anillos A y C de olean-12-enos naturales para la obtención de sintones quirales

January 2003 in “Dialnet (Universidad de la Rioja)”

The study found ways to create important compounds for male health from olive waste.

research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1

28 citations , September 2000 in “Journal of Medicinal Chemistry”

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

research Arecaceae

October 2015 in “Elsevier eBooks”

Chewing betel nut may increase the risk of type 2 diabetes, and saw palmetto can improve urinary symptoms in BPH with fewer side effects but may cause bleeding and allergic reactions.

research Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5-aryl-1,3,4-Oxadiazole Analogues

8 citations , January 2013 in “Medicinal chemistry”

The compound 4c showed strong potential as an anticancer agent.

research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

November 2023

New steroid derivatives show promise as anticancer agents, even against resistant cells.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle

149 citations , March 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

research Hypertrichosis due to minoxidil

45 citations , November 1979 in “British Journal of Dermatology”

Minoxidil causes excessive hair growth in almost all patients.

$Minoxidil in Refractory Hypertension$

research Minoxidil in refractory hypertension

17 citations , April 1975 in “The Journal of Pediatrics”

Minoxidil effectively controls severe high blood pressure in children with few side effects.

research Method development and estimation of minoxidil by gas chromatography

January 2026 in “National Journal of Pharmaceutical Sciences”

A new method using gas chromatography effectively measures minoxidil in drugs and biological samples.

research Agent: Minoxidil

January 2018 in “Elsevier eBooks”

Minoxidil helps lower severe blood pressure and promotes hair growth but can have serious side effects and must be used continuously.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

research Towards sustainable and scalable synthesis of amitriptyline hydrochloride, minoxidil, and pyrrolidinyl diaminopyrimidine oxide

1 citations , May 2025 in “Journal of the Indian Chemical Society”

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from (278.15 to 333.15) K

24 citations , April 2011 in “Journal of Chemical & Engineering Data”

Minoxidil dissolves best in methanol and least in water.

research Synthesis and anticancer activity of phenylpropanoid sucrose esters

4 citations , January 2011

Phenylpropanoid sucrose esters show potential as anticancer agents.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Molecular Interactions of New Pregnenedione Derivatives

20 citations , January 2003 in “Chemical and Pharmaceutical Bulletin”

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

research N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

17 citations , December 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists found new, better-working inhibitors for a hormone-related enzyme.

Minoxidil–2-Hydroxypropyl-β-Cyclodextrin Inclusion Complexes: Characterization and In Vivo Evaluation of an Aqueous Solution for Hair Growth in Rats

research Minoxidil–2-hydroxypropyl-β-cyclodextrin inclusion complexes: characterization and in vivo evaluation of an aqueous solution for hair growth in rats

16 citations , March 2017 in “Journal of inclusion phenomena and macrocyclic chemistry”

Minoxidil mixed with 2-hydroxypropyl-β-cyclodextrin in water can improve hair growth more than minoxidil alone.

Pyrene Excimer Nucleic Acid Probes for Biomolecule Signaling

research MINOXIDIL IN RESISTANT HYPERTENSION

102 citations , September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

research Minoxidil in severe hypertension with renal failure

100 citations , March 1973 in “American Journal of Cardiology”

Minoxidil effectively lowers blood pressure without major side effects.

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