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GlossaryPostbiotics

Postbiotics are bioactive compounds produced during the fermentation process by probiotics, which can have beneficial effects on health, including hair health. In the context of hair loss and hair biology, postbiotics may help modulate inflammation and support the scalp's microbiome, potentially influencing hair growth and retention. Key distinguishing characteristics of postbiotics include their ability to exert health benefits without the need for live microorganisms, making them a stable and safe option for promoting scalp health.

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Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Areata: A Randomized Double-Blinded Parallel-Group Study

research Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Area Celsi: A Randomized Double-Blinded Parallel-Group Study

17 citations , April 2020 in “Dermatology and Therapy”

The PRP-like cosmetic product with postbiotics effectively treats hair loss in Alopecia areata.

Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome

research Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome

September 2023 in “Clinical, cosmetic and investigational dermatology”

SLFC can improve scalp health and reduce sensitive scalp symptoms.

research Upcycled Postbiotic Cell-Free Supernatants from Limosilactobacillus fermentum MG901 and MG4237 Alleviated Oxidative Stress-Induced Dysfunction in Human Follicle Dermal Papilla Cells

February 2026 in “Cosmetics”

These supernatants may help reduce hair loss by protecting hair cells.

research Modulating the Gut–Skin Axis in Dermatological Diseases: Mechanisms and Clinical Applications of Probiotics, Prebiotics, Synbiotics, and Postbiotics

February 2026 in “International Journal of Clinical Dermatology”

Certain probiotics can help improve skin conditions like atopic dermatitis, but more research is needed.

Targeting the Gut Microbiota with Probiotics and Postbiotics: Emerging Strategies Against Alopecia

research Targeting the Gut Microbiota with Pro- and Postbiotics: Emerging Strategies against Alopecia

February 2026 in “Probiotics and Antimicrobial Proteins”

Modifying gut bacteria with pro- and postbiotics may help treat hair loss.

research Multi-omics revealed that the postbiotic of hawthorn-probiotic alleviated constipation caused by loperamide in elderly mice

1 citations , February 2025 in “Frontiers in Nutrition”

Hawthorn-probiotic postbiotic may relieve constipation in elderly.

research Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata

22 citations , April 2020 in “Frontiers in Cellular and Infection Microbiology”

Alopecia areata may be linked to scalp microbiome differences, suggesting potential treatments with prebiotics, probiotics, and postbiotics.

research Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis

15 citations , October 2024 in “Nutrients”

A plant-based diet and certain probiotics may improve skin health and reduce inflammation.

research Clinical Translation of Microbiome Research in Alopecia Areata: A New Perspective?

2 citations , May 2022 in “Cosmetics”

Further research is needed to understand how the microbiome affects hair loss in Alopecia Areata.

research Understanding the Impact of the Skin Microbiome on Dermatological Assessments and Therapeutic Innovation

November 2025 in “Dermato”

The skin microbiome is crucial for skin health and new treatments like probiotics can improve skin conditions.

research The Gut-Scalp Axis: A Systematic Review of Dietary Interventions on Microbiome Dysbiosis in Scalp Disorders

November 2025 in “Journal of Pioneering Medical Science”

Dietary interventions improved hair density and reduced dandruff by balancing scalp microbiota and reducing inflammation.

research Hydrobiome of Thermal Waters: Potential Use in Dermocosmetics

June 2023 in “Cosmetics”

Thermal spring waters and their microbes could be good for skin health and treating some skin conditions in skincare products.

research ‘Omics’ Approaches for Studying the Microbiome in Alopecia Areata

September 2020 in “Journal of Investigative Medicine”

Omics techniques are needed to understand the scalp microbiome's role in alopecia areata for new treatments.

Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision Between Stem Cell Maintenance and Differentiation

research Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation

1 citations , December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Sox9 levels in brain stem cells affect whether they stay as stem cells or become neurons.

research Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin

25 citations , September 1995 in “Biochemistry and Cell Biology”

High levels of human keratin 16 in mice cause skin lesions and abnormal skin development.

research SCALP MICROBIOME IN ALOPECIA: A NEW DIRECTION IN TRICHOLOGICAL DIAGNOSTICS AND FOLLICLE RESTORATION

February 2026 in “Middle European Scientific Bulletin”

Improving scalp microbiome may help restore hair and improve scalp health.

research Biotransformation of Cacumen platycladi Extract by Lactiplantibacillus plantarum CCFM1348 Promotes Hair Growth in Mice

May 2024 in “Journal of Agricultural and Food Chemistry”

Biotransformed Cacumen platycladi extract promotes hair growth in mice.

research Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.

94 citations , October 1994 in “The Journal of Cell Biology”

Too much keratin 16 in mice skin causes abnormal skin thickening and structure.

ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research eLife assessment: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

February 2024

Meis2 is essential for touch sensation and proper nerve connection to touch receptors in certain skin areas of mice.

research Recent advances in understanding the role of the skin microbiome in the treatment of atopic dermatitis

18 citations , September 2023 in “Experimental Dermatology”

The skin microbiome plays a key role in treating atopic dermatitis.

Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

research Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation

42 citations , June 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

PAI-2 helps in the maturation and protection of hair and nail cells.

research Oxidative stress in ageing of hair

126 citations , January 2009 in “International Journal of Trichology”

Oxidative stress contributes to hair graying and loss as we age.

research Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling

116 citations , May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis

106 citations , October 2016 in “Cell Stem Cell”

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

research Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia

54 citations , January 2009 in “British Journal of Dermatology”

Scarring alopecia affects different hair follicle stem cells than nonscarring alopecia, and the infundibular region could be a new treatment target.

BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

research BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor under Steady-State Conditions

50 citations , September 2014 in “Stem cell reports”

BLIMP1 is essential for skin maintenance but not for defining sebaceous gland progenitors.

research Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying

30 citations , April 2013 in “Journal of Investigative Dermatology”

Radiation mainly affects keratinocyte stem cells, not melanocyte stem cells, causing hair to gray.

research Epidermal keratinocyte stem cells: their maintenance and regulation

25 citations , December 1992 in “Seminars in cell biology”

Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.

Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury

research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury

6 citations , February 2022 in “The journal of neuroscience/The Journal of neuroscience”

Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.